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Interplay Between MicroRNAs and Targeted Genes in Cellular Homeostasis of Adult Zebrafish (Danio rerio)

Autor: Gary Hardiman, Ludivine Renaud, Willian A. da Silveira, William B. Glen, Edward S Hazard

Publikováno v: Current Genomics

Background Cellular homeostasis is regulated by the intricate interplay between a plethora of signaling pathways and "energetic sensors" in organs. In order to maintain energy balance, induction or repression of metabolic pathways must be regulated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402928c279522e70a3e3e36c50bc87a4
https://doi.org/10.2174/1389202919666180503124522

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Ground-Penetrating-Radar Characterization and Porosity Evolution of An Upper Pleistocene Oolite-Capped Depositional Cycle, Red Bays, Northwest Andros Island, Great Bahama Bank

Autor: Scott M. Ritter, Colby S. Hazard, John H. McBride, David G. Tingey, R. William Keach

Publikováno v: Journal of Sedimentary Research. 87:523-545

Linkages among surface sediments, depositional processes, geomorphic forms, stratigraphic architecture, and pore distribution in Bahamian sand bodies and oolite-capped depositional successions have been characterized in recent studies. An understandi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3141ce28c2bf716b478af117f0144d3
https://doi.org/10.2110/jsr.2017.9

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Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma

Autor: Reniqua House, Sudha Talwar, Sean M. Courtney, Gary Hardiman, Viswanathan Palanisamy, Harinarayanan Janakiraman, Shikhar Mehrotra, Vamsi K. Gangaraju, Edward S Hazard, Philip H. Howe

Publikováno v: Oncogene

A well-studied RNA-binding protein Hu Antigen-R (HuR), controls post-transcriptional gene regulation and undergoes stress-activated caspase-3 dependent cleavage in cancer cells. The cleavage products of HuR are known to promote cell death; however, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4816095bbda3666c5530e922de16355
https://doi.org/10.1038/onc.2016.451

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GAIL: An interactive webserver for inference and dynamic visualization of gene-gene associations based on gene ontology guided mining of biomedical literature

Autor: Carter Allen, Willian A. da Silveira, Jin Hyun Nam, Kelly J. Hunt, Daniel Couch, Edward S Hazard, Gary Hardiman, Zhenning Yu, Andrew B. Lawson, Paula S. Ramos, Dongjun Chung

Publikováno v: Couch, D, Yu, Z, Nam, J H, Allen, C, Ramos, P S, da Silveira, W A, Hunt, K J, Hazard, E S, Hardiman, G, Lawson, A & Chung, D 2019, ' GAIL: An interactive webserver for inference and dynamic visualization of gene-gene associations based on gene ontology guided mining of biomedical literature ', PLoS ONE, vol. 14, no. 7, e0219195 . https://doi.org/10.1371/journal.pone.0219195
PLoS ONE, Vol 14, Iss 7, p e0219195 (2019)
PLoS ONE

In systems biology, inference of functional associations among genes is compelling because the construction of functional association networks facilitates biomarker discovery. Specifically, such gene associations in human can help identify putative b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e443c176f3244558861336f33902762
https://pure.qub.ac.uk/en/publications/gail-an-interactive-webserver-for-inference-and-dynamic-visualization-of-genegene-associations-based-on-gene-ontology-guided-mining-of-biomedical-literature(7e9ba576-2967-421a-b1de-e8296012972a).html

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miRmapper: A Tool for Interpretation of miRNA–mRNA Interaction Networks

Autor: Gary Hardiman, Edward S Hazard, Jonathan Simpson, Dongjun Chung, Ludivine Renaud, William B. Glen, Willian A. da Silveira

Publikováno v: Genes
Volume 9
Issue 9
da Silveira, W, Renaud, L, Simpson, J, Glenn Jr., W B, Hazard, E S, Chung, D & Hardiman, G 2018, ' miRmapper: A Tool for Interpretation of miRNA–mRNA Interaction Networks ', Genes, vol. 9, no. 9, 458 . https://doi.org/10.3390/genes9090458, https://doi.org/10.3390/genes9090458
Genes, Vol 9, Iss 9, p 458 (2018)

It is estimated that 30% of all genes in the mammalian cells are regulated by microRNA (miRNAs). The most relevant miRNAs in a cellular context are not necessarily those with the greatest change in expression levels between healthy and diseased tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7737558e0b018f14a0374ceb93105b80
https://doi.org/10.3390/genes9090458

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