KNIME workflows for applications in medicinal and computational chemistry

Autor: Ruchira Joshi, Zipeng Zheng, Palak Agarwal, Ma’mon M. Hatmal, Xinmin Chang, Paul Seidler, Ian S. Haworth

Publikováno v: Artificial Intelligence Chemistry, Vol 2, Iss 1, Pp 100063- (2024)

Artificial intelligence (AI) has huge potential to accelerate drug discovery, but challenges remain in implementing AI algorithms that can be used by the broad scientific community. Identification of molecular features and their subsequent use in tra

Externí odkaz: https://doaj.org/article/224523efe41347cb88090117711fb668

BronchUK: protocol for an observational cohort study and biobank in bronchiectasis

Autor: Anthony De Soyza, Philip Mawson, Adam T. Hill, Stuart Elborn, Judy M. Bradley, Charles S. Haworth, R. Andres Floto, Robert Wilson, Michael R. Loebinger, Mary Carroll, Megan Crichton, James D. Chalmers, Anita Sullivan, Jeremy Brown, John R. Hurst, Jamie Duckers, Martin Kelly, John Steer, Tim Gatheral, Paul P. Walker, Craig Winstanley, Alistair McGuire, David Denning, Richard McNally

Publikováno v: ERJ Open Research, Vol 7, Iss 2 (2021)

Bronchiectasis has been a largely overlooked disease area in respiratory medicine. This is reflected by a shortage of large-scale studies and lack of approved therapies, in turn leading to a variation of treatment across centres. BronchUK (Bronchiect

Externí odkaz: https://doaj.org/article/54698cb8547746ac8a06a7230fbcd6c9

The Italian registry of pulmonary non-tuberculous mycobacteria - IRENE: the study protocol

Autor: Stefano Aliberti, Luigi Ruffo Codecasa, Andrea Gori, Giovanni Sotgiu, Maura Spotti, Antonio Di Biagio, Andrea Calcagno, Stefano Nardini, Baroukh Maurice Assael, Enrico Tortoli, Giorgio Besozzi, Maurizio Ferrarese, Alberto Matteelli, Enrico Girardi, Saverio De Lorenzo, Manuela Seia, Andrea Gramegna, Bruno Del Prato, Leonardo Terranova, Martina Oriano, Nicola Sverzellati, Mehdi Mirsaeidi, James D. Chalmers, Charles S. Haworth, Michael R. Loebinger, Timothy Aksamit, Kevin Winthrop, Felix C. Ringshausen, Giuliana Previdi, Francesco Blasi, on behalf of the IRENE Network

Publikováno v: Multidisciplinary Respiratory Medicine, Vol 13, Iss S1, Pp 15-20 (2018)

Abstract Background A substantial increase in pulmonary and extra-pulmonary diseases due to non-tuberculous mycobacteria (NTM) has been documented worldwide, especially among subjects suffering from chronic respiratory diseases and immunocompromised

Externí odkaz: https://doaj.org/article/193094077bef4589b9c83b289306c605

Genome-wide Scan of Dental Fear and Anxiety Nominates Novel Genes

Autor: Y. Zhou, D.W. McNeil, S. Haworth, T. Dudding, J.M. Chernus, C. Liu, D. Liu, C.D. Wright, J. Brumbaugh, C.L. Randall, R.J. Weyant, R.J. Crout, B. Foxman, S. Reis, N.J. Timpson, M.L. Marazita, J.R. Shaffer

Publikováno v: Zhou, Y, McNeil, D W, Haworth, S, Dudding, T, Chernus, J M, Liu, C, Liu, D, Wright, C D, Brumbaugh, J, Randall, C L, Weyant, R J, Crout, R J, Foxman, B, Reis, S, Timpson, N J, Marazita, M L & Shaffer, J R 2022, ' Genome-wide Scan of Dental Fear and Anxiety Nominates Novel Genes ', Journal of Dental Research, vol. 101, no. 12, pp. 1526-1536 . https://doi.org/10.1177/00220345221105226

Dental care–related fear and anxiety (DFA) is prevalent, affects oral health care utilization, and is related to poor oral health and decreased quality of life. In addition to learned and cultural factors, genetics is hypothesized to contribute to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0bafb0eced31c1f330461487e68c89
https://doi.org/10.1177/00220345221105226

Bronchiectasis in Europe: data on disease characteristics from the European Bronchiectasis registry (EMBARC)

Autor: James D Chalmers, Eva Polverino, Megan L Crichton, Felix C Ringshausen, Anthony De Soyza, Montserrat Vendrell, Pierre Régis Burgel, Charles S Haworth, Michael R Loebinger, Katerina Dimakou, Marlene Murris, Robert Wilson, Adam T Hill, Rosario Menendez, Antoni Torres, Tobias Welte, Francesco Blasi, Josje Altenburg, Michal Shteinberg, Wim Boersma, J Stuart Elborn, Pieter C Goeminne, Stefano Aliberti

Publikováno v: EMBARC Registry Investigators 2023, ' Bronchiectasis in Europe : data on disease characteristics from the European Bronchiectasis registry (EMBARC) ', The Lancet Respiratory Medicine, vol. 11, no. 7, pp. 637-649 . https://doi.org/10.1016/S2213-2600(23)00093-0

Background: Bronchiectasis is a heterogeneous, neglected disease with few multicentre studies exploring the causes, severity, microbiology, and treatment of the disease across Europe. This aim of this study was to describe the clinical characteristic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79b73767457060be6a35ebc0cc085b1
https://doi.org/10.1016/s2213-2600(23)00093-0