Zobrazeno 1 - 10
of 15
pro vyhledávání: '"S. Harsha Krovi"'
Autor:
S. Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of development
Externí odkaz:
https://doaj.org/article/06e13866d71d4727a0acfddef21305ab
Autor:
Kathryn D. Tuttle, S. Harsha Krovi, Jingjing Zhang, Romain Bedel, Laura Harmacek, Lisa K. Peterson, Leonard L. Dragone, Adam Lefferts, Catherine Halluszczak, Kent Riemondy, Jay R. Hesselberth, Anjana Rao, Brian P. O’Connor, Philippa Marrack, James Scott-Browne, Laurent Gapin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces
Externí odkaz:
https://doaj.org/article/9d629b4edd534fecb283ec7b354fbbc7
Autor:
S. Harsha Krovi, Laurent Gapin
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Invariant natural killer T (iNKT) cells are a CD1d-restricted T cell population that can respond to lipid antigenic stimulation within minutes by secreting a wide variety of cytokines. This broad functional scope has placed iNKT cells at the frontlin
Externí odkaz:
https://doaj.org/article/f3e61e2efc7b4fbe86bd0258ec651d1d
Publikováno v:
Seminars in immunology. 60
Innate T (T
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22252-22261
The repertoire of αβ T cell antigen receptors (TCRs) on mature T cells is selected in the thymus where it is rendered both self-tolerant and restricted to the recognition of major histocompatibility complex molecules presenting peptide antigens (pM
Autor:
Laurent Gapin, Tonya Brunetti, Mary Jessamine Michaels-Foster, Liyen Loh, James P. Scott-Browne, S. Harsha Krovi, Jingjing Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Most T lymphocytes leave the thymus as naïve cells with limited functionality. However, unique populations of innate-like T cells differentiate into functionally distinct effector subsets during their development in the thymus. Here, we profiled >10
Autor:
Ryan C. Hill, Frances Crawford, S. Harsha Krovi, Kirk C. Hansen, John W. Kappler, Philippa Marrack, Janice White, Niyun Jin, Brendan K Reed
Publikováno v:
The Journal of Experimental Medicine
The lysosomal protease cathepsin L uses pancreatic secretory granule protein precursors and a reverse proteolysis mechanism, transpeptidation, to generate chimeric super-epitopes specific for diabetogenic CD4 T cells.
The identification of the p
The identification of the p
Autor:
Kent Riemondy, Anjana Rao, Brian P. O'Connor, S. Harsha Krovi, Laurent Gapin, Adam R. Lefferts, Jay R. Hesselberth, Leonard L. Dragone, Catherine Halluszczak, Philippa Marrack, Jingjing Zhang, Lisa K. Peterson, Kathryn D. Tuttle, Laura Harmacek, James P. Scott-Browne, Romain Bedel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature communications, vol. 9, no. 1, pp. 2650
Nature Communications
Nature communications, vol. 9, no. 1, pp. 2650
During development in the thymus, invariant natural killer T (iNKT) cells commit to one of three major functionally different subsets, iNKT1, iNKT2, and iNKT17. Here, we show that T cell antigen receptor (TCR) signal strength governs the development
Autor:
Laurent Gapin, S. Harsha Krovi
Publikováno v:
Immunogenetics. 68:549-559
Polymorphic major histocompatibility complex (MHC) molecules play a central role in the vertebrate adaptive immune system. By presenting short peptides derived from pathogen-derived proteins, these "classical" MHC molecules can alert the T cell branc
Autor:
Laurent Gapin, S. Harsha Krovi
Publikováno v:
Nature Immunology. 18:148-150
The epigenetic regulation of gene expression by the histone demethylase UTX is central to the development of invariant natural killer cells.