Zobrazeno 1 - 10
of 19
pro vyhledávání: '"S. H. Sacks"'
Publikováno v:
International urology and nephrology. 33(1)
Many patients with idiopathic membranous nephropathy are elderly, but little is known about the natural or treated history of these patients. We have studied a cohort of 155 patients with membranous nephropathy who were recruited and followed-up over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d24f90ce65a995ddee32f2d7ffc2be5
https://pubmed.ncbi.nlm.nih.gov/12090324
https://pubmed.ncbi.nlm.nih.gov/12090324
Publikováno v:
Archivum immunologiae et therapiae experimentalis. 49
Complement is important to host defense and the regulation of inflammation. The liver is overwhelmingly the major source of circulating complement. However, many other organs are capable of synthesizing some or all of the complement components in a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43d0c6dbe0254e589653ed3c47914c41
https://pubmed.ncbi.nlm.nih.gov/11603868
https://pubmed.ncbi.nlm.nih.gov/11603868
Publikováno v:
Transplantation. 72(7)
The mechanisms controlling the production of antibodies against histocompatibility antigens are of prime importance in organ transplantation.We investigated the role of complement in the response to allogeneic stimulation, using mice deficient in C3,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81f595fd9ebf231b77321b3e4f5bbc40
https://pubmed.ncbi.nlm.nih.gov/11602861
https://pubmed.ncbi.nlm.nih.gov/11602861
Publikováno v:
Transplantation. 72(6)
At present, it is not clear whether xenogeneic MHC molecules are recognized by T cells directly or indirectly through self-MHC-restricted presentation in a transplantation setting.We have transplanted skin from HLA-A2 transgenic (B6.A2) to nontransge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e11e94a187005b106a8172f1a576ce5
https://pubmed.ncbi.nlm.nih.gov/11579290
https://pubmed.ncbi.nlm.nih.gov/11579290
Publikováno v:
European journal of immunology. 31(4)
The role of complement in autoimmune glomerulonephritis (as in other autoimmune diseases) is paradoxical, in that complement activation mediates acute inflammatory injury, yet inherited deficiency of complement may predispose to immune complex diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3f93903b91af933652237aa167c7908
https://pubmed.ncbi.nlm.nih.gov/11298352
https://pubmed.ncbi.nlm.nih.gov/11298352
Autor:
N S, Sheerin, S H, Sacks
Publikováno v:
Nephrologie. 20(7)
The deposition of complement components is a feature of many immune mediated human glomerular diseases. Experimental models provide evidence that complement activation within the glomerulus has a pathogenic role in immune complex and antibody mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb049e8c47ca6017b8552b8779f33a05
https://pubmed.ncbi.nlm.nih.gov/10642986
https://pubmed.ncbi.nlm.nih.gov/10642986
Publikováno v:
European journal of immunology. 29(12)
HLA-DM is an MHC class II-related heterodimer that is targeted to lysosomal compartments by a tyrosine-based signal YTPL, present in the cytoplasmic tail of the beta chain. Similar signals in other proteins control transport to different intracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bcb0b3dd6bea439b7a4676b19974ba1e
https://pubmed.ncbi.nlm.nih.gov/10602001
https://pubmed.ncbi.nlm.nih.gov/10602001
Autor:
N S, Sheerin, S H, Sacks
Publikováno v:
Kidneyblood pressure research. 22(1-2)
Tubulointerstitial injury is seen in some patients with glomerular proteinuria and when present is a poor prognostic indicator. However, the mechanism by which proteinuria results in tubular and interstitial damage is unknown. Activation of the compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4b82bb16a59192c0546495267210984
https://pubmed.ncbi.nlm.nih.gov/10352407
https://pubmed.ncbi.nlm.nih.gov/10352407
Publikováno v:
Immunology. 93(4)
Peptide loading by major histocompatibility complex (MHC) class II molecules occurs in the endocytic pathway and is critically dependent upon the function of the class II-related molecule human leucocyte antigen-DM (HLA-DM). We have previously shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d163c4157f1344f944fb41b596db6ee
https://pubmed.ncbi.nlm.nih.gov/9659222
https://pubmed.ncbi.nlm.nih.gov/9659222
Publikováno v:
Transplantation. 61(5)
Small vessel thrombosis is a prominent feature in kidneys undergoing vascular rejection. Type I and type 2 plasminogen activator inhibitors (PAI-1 and PAI-2, respectively) are known to mediate thrombosis. To examine the potential role of PAI-1 and PA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64c119850d6ffcb21684c1de327708e2
https://pubmed.ncbi.nlm.nih.gov/8607167
https://pubmed.ncbi.nlm.nih.gov/8607167