Zobrazeno 1 - 10
of 34
pro vyhledávání: '"S. H. Leppla"'
Publikováno v:
Human Immunology. 54:129-136
Cytotoxic T lymphocytes (CTL) recognize antigens derived from endogenously expressed proteins presented on the cell surface in the context of major histocompatibility complex (MHC) class I molecules. Because CTL are effective in antiviral and antitum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71452049f2e11b661293013119dc704b
https://doi.org/10.1016/s0198-8859(97)00081-5
https://doi.org/10.1016/s0198-8859(97)00081-5
Publikováno v:
Infection and Immunity. 63:82-87
Before intoxication can occur, anthrax toxin protective antigen (PA), Pseudomonas exotoxin A (PE), and diphtheria toxin (DT) must be activated by proteolytic cleavage at specific amino acid sequences. Previously, it was shown that PA and DT can be ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770aa75b43914189e0780b595b1226f9
https://doi.org/10.1128/iai.63.1.82-87.1995
https://doi.org/10.1128/iai.63.1.82-87.1995
Autor:
S H Leppla, Naveen Arora
Publikováno v:
Journal of Biological Chemistry. 268:3334-3341
Anthrax lethal toxin is a complex of protective antigen (PA, 735 amino acids) and lethal factor (LF, 776 amino acids) that lyses certain eukaryotic cells. LF interacts with PA to gain access to the cytosol to assert its toxicity. The internalization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac18b1373a303beb76f9cf6a9ac7d69d
https://doi.org/10.1016/s0021-9258(18)53698-x
https://doi.org/10.1016/s0021-9258(18)53698-x
Publikováno v:
Journal of Biological Chemistry. 267:16396-16402
Previous work demonstrated that human furin is a predominantly Golgi membrane-localized endoprotease that can efficiently process precursor proteins at paired basic residues (-Lys-Arg- or -Arg-Arg-) in transfected cells. Anion-exchange chromatography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98968d3f4f92633c1184951b44577e2f
https://doi.org/10.1016/s0021-9258(18)42016-9
https://doi.org/10.1016/s0021-9258(18)42016-9
Publikováno v:
Journal of Biological Chemistry. 267:15542-15548
The lethal factor (LF) and edema factor (EF) components of anthrax toxin are toxic to animal cells only if internalized by interaction with the protective antigen (PA) component. PA binds to a cell surface receptor and is proteolytically cleaved to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f95dc974c4be5da39cfca10ccd403389
https://doi.org/10.1016/s0021-9258(19)49569-0
https://doi.org/10.1016/s0021-9258(19)49569-0
Publikováno v:
Journal of industrial microbiologybiotechnology. 28(4)
The protective antigen (PA) is one of the three components of the anthrax toxin. It is a secreted nontoxic protein with a molecular weight of 83 kDa and is the major component of the currently licensed human vaccine for anthrax. Due to limitations fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::915d99583f2824bcbc6db80b3e38fea0
https://pubmed.ncbi.nlm.nih.gov/11986925
https://pubmed.ncbi.nlm.nih.gov/11986925
Autor:
Christina Niemeyer, J. Sun, Jian Hua Zheng, S. H. Leppla, Venkatachalapathi V. Yalamoori, N. Duesberry, Kalyanaraman Ramnarayan, Mark D. Shenderovich, M. G. de Luna, Darryl Rideout
Publikováno v:
Peptides: The Wave of the Future ISBN: 9789401039055
Bacillus anthracis, the cause of anthrax, poses a considerable danger because of its potential use as a weapon by military organizations and terrorist groups. Respiratory anthrax infections are almost invariably fatal despite antibiotic treatment. An
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::601f1dd4830df740806527a81bbb2ef6
https://doi.org/10.1007/978-94-010-0464-0_310
https://doi.org/10.1007/978-94-010-0464-0_310
Publikováno v:
Cancer research. 60(21)
Matrix metalloproteinases (MMPs) are overexpressed in a variety of tumor tissues and cell lines, and their expression is highly correlated to tumor invasion and metastasis. To exploit these characteristics in the design of tumor cell-selective cytoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84ddb97204366de4960bc0516275174b
https://pubmed.ncbi.nlm.nih.gov/11085528
https://pubmed.ncbi.nlm.nih.gov/11085528
Autor:
S. H. Leppla
Publikováno v:
Bacterial Protein Toxins ISBN: 9783642085406
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c46018fde79f2f3ab70fc81033303c8b
https://doi.org/10.1007/978-3-662-05971-5_19
https://doi.org/10.1007/978-3-662-05971-5_19
Autor:
F. G. van der Goot, François Jean, N.G. Seidah, Etienne Decroly, S H Leppla, J T Buckley, Marc Fivaz, George Thomas, Laurence Abrami
Publikováno v:
The Journal of biological chemistry. 273(49)
Aerolysin is secreted as an inactive dimeric precursor by the bacterium Aeromonas hydrophila. Proteolytic cleavage within a mobile loop near the C terminus of the protoxin is required for oligomerization and channel formation. This loop contains the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e88eb21abac38b5a5c02be656a350c8
https://pubmed.ncbi.nlm.nih.gov/9830006
https://pubmed.ncbi.nlm.nih.gov/9830006