Výsledky vyhledávání

Interleukin-7 selectively enhances natural kill cytotoxicity mediated by the CD56bright natural killer subpopulation

Autor: R, Dadmarz, D C, Bockstoce, S H, Golub

Publikováno v: Lymphokine and cytokine research. 13(6)

Both the CD56bright and CD56dim NK cell subpopulation mediate non-major histocompatibility complex-restricted cytolysis of NK-sensitive tumor cell lines, and IL-2-dependent augmentation of cytolysis and proliferation of CD56bright and CD56dim NK cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2faa67019a21db00260f57a7d6e703bb
https://pubmed.ncbi.nlm.nih.gov/7535569

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Interleukin-6 is a mediator of TNF-alpha regulation of LAK cell function

Autor: S. Iho, Hungyi Shau, S. H. Golub

Publikováno v: Scandinavian journal of immunology. 38(2)

TNF-alpha at 50-100 U/ml synergizes with IL-2 in enhancing LAK activity and IL-6 production in low-dose IL-2 (1-10 U/ml) culture of human PBL. High-dose TNF-alpha (> or = 200 U/ml) has less effect and even sometimes resulted in lowering of both LAK a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9384beff59a8dacc3ceaa7e9a7823c
https://pubmed.ncbi.nlm.nih.gov/8346413

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Regulation of natural killer function by nonlymphoid cells

Autor: H, Shau, M D, Roth, S H, Golub

Publikováno v: Natural immunity. 12(4-5)

Natural killer (NK) cells and interleukin-2 activated NK cells, termed lymphokine-activated killer (LAK) cells, can lyse tumor cells without restriction by the MHC complex. The cytotoxic activity of these cells is subject to regulation by nonlymphoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6be86a7f7d131502e8429ca8414b58ab
https://pubmed.ncbi.nlm.nih.gov/8257829

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The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines

Autor: K L, Rhoades, S H, Golub, J S, Economou

Publikováno v: The Journal of biological chemistry. 267(31)

The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region was fused to the luciferase (Luc) reporter gene and studied in a transient transfection system in three TNF producing cell lines, the U937 macrophage cell line, the MLA 144 T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea0ecd63e86c9080475143b8383853d6
https://pubmed.ncbi.nlm.nih.gov/1429562

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Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin

Autor: H, Shau, A, Kim, S H, Golub

Publikováno v: Journal of leukocyte biology. 51(4)

Natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxic functions can be strongly augmented by the iron-carrier protein lactoferrin (LF). LF significantly enhances NK and LAK activities when added at the beginning of NK or LAK cytoto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c217b8e33cb1aed3dc77cae0871a30dc
https://pubmed.ncbi.nlm.nih.gov/1564398

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A pilot study of intralymphatic interleukin-2. I. Cytotoxic and surface marker changes of peripheral blood lymphocytes

Autor: H, Shau, V, Isacescu, Y, Ibayashi, Y, Tokuda, S H, Golub, J L, Fahey, G P, Sarna

Publikováno v: Journal of biological response modifiers. 9(1)

Patients with metastatic solid tumors were treated with six escalating doses of weekly intralymphatically injected recombinant interleukin 2 (i.l. IL-2). Nine patients completed the treatment and were evaluated for immunologic features of their perip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a6c504b42af3c0e8eabbce6c1673f6e
https://pubmed.ncbi.nlm.nih.gov/2319261

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Characteristics and mechanism of IFN-gamma-induced protection of human tumor cells from lysis by lymphokine-activated killer cells

Autor: R U de Fries, S H Golub

Publikováno v: The Journal of Immunology. 140:3686-3693

IFN-gamma has been shown to reduce the sensitivity of tumor cells to lysis by NK cells. The close relationship between NK cells and lymphokine-activated killer (LAK) cells has prompted us to investigate whether IFN-gamma pre-treatment also affects th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61e2ed499ef7adf75733a8b0fac68aed
https://doi.org/10.4049/jimmunol.140.10.3686

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