Zobrazeno 1 - 8
of 8
pro vyhledávání: '"S. H. Fernandez Villamil"'
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects 7 million people worldwide. Considering the side effects and drug resistance shown by current treatments, the development of new anti-Chagas therapies is an urgent need.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ed5e494a231941425a5342e292fa8e
https://linkinghub.elsevier.com/retrieve/pii/S0006295221001209
https://linkinghub.elsevier.com/retrieve/pii/S0006295221001209
Autor:
Marta Dubin, S. H. Fernandez Villamil, M. A. Brusa, Andrés O.M. Stoppani, R. P. Duran, L. J. Perissinotti
Publikováno v:
Free Radical Research Communications. 10:351-360
Nifurtimox analogues bearing triazol-4-yl, benzimidazol-1-yl, triazin-4-yl or related groups as counterpart of the (5-nitro-2-furfurylidene) amino group were reduced to their nitro anion radicals by ascorbate in anaerobic solutions at high pH. The ES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25eb1ad418c0c796ba36fe7e2c8d732d
https://doi.org/10.3109/10715769009149904
https://doi.org/10.3109/10715769009149904
Publikováno v:
Revista Argentina de microbiologia. 35(2)
Fenton systems (H2O2/Fe(II) or H2O2/Cu(II)) inhibited Trypanosoma cruzi and Crithidia fasciculata topoisomerase I activity. About 61-71% inactivation was produced by 25 mM Fe(II) or Cu(II) with 3 mM H2O2. Thiol compounds and free radicals scavengers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e47339809b80ced67f55206ee70a9f1
https://pubmed.ncbi.nlm.nih.gov/12920988
https://pubmed.ncbi.nlm.nih.gov/12920988
Publikováno v:
Medicina. 61(3)
beta-lapachone (beta-lap) is a lipophilic o-naphthoquinone isolated from the bark of the lapacho tree. Initial observations proved its capability for inhibiting growth of Yoshida tumor and Walker 256 carcinosarcoma. beta-Lap redox-cycling in the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2620369a8bba8d8ee068855840a04409
https://pubmed.ncbi.nlm.nih.gov/11474885
https://pubmed.ncbi.nlm.nih.gov/11474885
Publikováno v:
Biochemical pharmacology. 52(12)
beta-Lapachone and structurally related lipophilic o-naphthoquinones, namely, CG 8-935, CG 9-442, CG 10-248 and mansonones A, C, E, and F, were investigated for redox cycling, production of reactive oxygen species, and cytotoxicity in the trypanosoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6dae377fda39626ddb1e8ca8b46f7874
https://pubmed.ncbi.nlm.nih.gov/8951346
https://pubmed.ncbi.nlm.nih.gov/8951346
Publikováno v:
Revista Argentina de microbiologia. 26(2)
ATP and ADP levels were determined in Crithidia fasciculata and Trypanosoma cruzi. The nucleotide levels in crithidia or epimastigotes at the stationary phase of growth were, in nmol/10(8) cells, 15-40, and 3-7, for ATP and ADP, respectively. Incubat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a7202470b011dc47a8cae3ff1bd5640
https://pubmed.ncbi.nlm.nih.gov/7938505
https://pubmed.ncbi.nlm.nih.gov/7938505
Publikováno v:
Free radical research communications. 14(5-6)
(5-Nitro-2-furfurylidene)amino compounds bearing triazol-4-yl, benzimidazol-1-yl, pyrazol-1-yl, triazin-4-yl or related groups (a) stimulated superoxide anion radical generated by rat liver microsomes in the presence of NADPH and oxygen; (b) inhibite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925d1871dcc79225ac1113dacc006d7c
https://pubmed.ncbi.nlm.nih.gov/1663909
https://pubmed.ncbi.nlm.nih.gov/1663909
Publikováno v:
FEBS letters. 220(1)
Two nitrofuran compounds, nifurtimox and nitrofurantoin, inhibited in a concentration-dependent manner the NADPH-, iron-induced lipid peroxidation in rat liver microsomes, as shown by the decreased rate of MDA accumulation. Other nitro compounds (ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da709d3b534c8a377020decb72d4120
https://pubmed.ncbi.nlm.nih.gov/3609311
https://pubmed.ncbi.nlm.nih.gov/3609311