Zobrazeno 1 - 10
of 866
pro vyhledávání: '"S. Gujral"'
Autor:
F. Maggiulli, C. Hinton, L. Simpson, S. Gujral, J. Hardwicke, R. Slator, R.W. Pigott, T.L. Su, B. Richard
Publikováno v:
JPRAS Open, Vol 33, Iss , Pp 145-154 (2022)
Objective: To compare the symmetry of the lip following Rotation-Advancement cleft lip repair by Millard and Pigott and to investigate the effect on the symmetry of cleft side and gender by using different surgical protocols. Symmetry following cleft
Externí odkaz:
https://doaj.org/article/e1f1ff5bb7214e7c84a96e406764477d
Autor:
Donald Long, Jr., Marina Chan, Mingqi Han, Zeal Kamdar, Rosanna K. Ma, Pei-Yin Tsai, Adam B. Francisco, Joeva Barrow, David B. Shackelford, Mark Yarchoan, Matthew J. McBride, Lukas M. Orre, Nathaniel M. Vacanti, Taranjit S. Gujral, Praveen Sethupathy
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101699- (2024)
Summary: Fibrolamellar carcinoma (FLC) is a rare, lethal, early-onset liver cancer with a critical need for new therapeutics. The primary driver in FLC is the fusion oncoprotein, DNAJ-PKAc, which remains challenging to target therapeutically. It is c
Externí odkaz:
https://doaj.org/article/5fee8c91d0e84541891ec3ad5b4cbeeb
Autor:
Rosanna K Ma, Pei-Yin Tsai, Alaa R Farghli, Alexandria Shumway, Matt Kanke, John D Gordan, Taranjit S Gujral, Khashayar Vakili, Manabu Nukaya, Leila Noetzli, Sean Ronnekleiv-Kelly, Wendy Broom, Joeva Barrow, Praveen Sethupathy
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011216 (2024)
Fibrolamellar carcinoma (FLC) is a rare liver cancer that disproportionately affects adolescents and young adults. Currently, no standard of care is available and there remains a dire need for new therapeutics. Most patients harbor the fusion oncogen
Externí odkaz:
https://doaj.org/article/19487cd4b6304631ba2145c57eb9603a
Publikováno v:
eLife, Vol 12 (2024)
Cytokines and chemokines are secreted proteins that regulate various biological processes, such as inflammation, immune response, and cell differentiation. Therefore, disruption of signaling pathways involving these proteins has been linked to a rang
Externí odkaz:
https://doaj.org/article/0fcf3a1fbec64626b9c50c53992f296d
Autor:
Annabel T Olson, Yuqi Kang, Anushka M Ladha, Songli Zhu, Chuan Bian Lim, Behnam Nabet, Michael Lagunoff, Taranjit S Gujral, Adam P Geballe
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011169 (2023)
Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human diseases including Kaposi's sarcoma (KS), a leading cause of cancer in Africa and in patients with AIDS. KS tumor cells harbor KSHV predominantly in a latent form, while typically
Externí odkaz:
https://doaj.org/article/7bdbcc8d08244e078bda190c159e2904
Autor:
Matthew B. Friese, Taranjit S. Gujral, Arvind Palanisamy, Brittany Hemmer, Deborah J. Culley, Gregory Crosby
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionThe development and maintenance of neural circuits is highly sensitive to neural activity. General anesthetics have profound effects on neural activity and, as such, there is concern that these agents may alter cellular integrity and inte
Externí odkaz:
https://doaj.org/article/1ec1488a3491450195bd534c1525c94b
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 6, Pp 1-4 (2022)
Graphical Abstract The N‐terminus domain (NTD) of the SARS‐CoV‐2 Omicron variant spike protien strongly induces multiple inflammatory molecules in human peripheral blood mononuclear cells, unaffected by the mutations observed in the NTD. Olvere
Externí odkaz:
https://doaj.org/article/6db57cf13dcf4a5ea8ffcda770ae370c
Autor:
Yu Ling Huang, Lindsay K. Dickerson, Heidi Kenerson, Xiuyun Jiang, Venu Pillarisetty, Qiang Tian, Leroy Hood, Taranjit S. Gujral, Raymond S. Yeung
Publikováno v:
BME Frontiers, Vol 4 (2023)
In the era of personalized oncology, there have been accelerated efforts to develop clinically relevant platforms to test drug sensitivities of individual cancers. An ideal assay will serve as a diagnostic companion to inform the oncologist of the va
Externí odkaz:
https://doaj.org/article/43b2d1ba3f9349ed94f8b46945481809
Autor:
Marina Chan, Siddharth Vijay, John McNevin, M Juliana McElrath, Eric C Holland, Taranjit S Gujral
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 9, Pp 1-15 (2021)
Abstract Although 15–20% of COVID‐19 patients experience hyper‐inflammation induced by massive cytokine production, cellular triggers of this process and strategies to target them remain poorly understood. Here, we show that the N‐terminal do
Externí odkaz:
https://doaj.org/article/44d51e033dfc42b98ce0ad7ba88f050d
Autor:
Thomas Bello, Marina Chan, Martin Golkowski, Andrew G. Xue, Nithisha Khasnavis, Michele Ceribelli, Shao-En Ong, Craig J. Thomas, Taranjit S. Gujral
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 2, Pp 100007- (2021)
Summary: The ever-increasing size and scale of biological information have popularized network-based approaches as a means to interpret these data. We develop a network propagation method that integrates kinase-inhibitor-focused functional screens wi
Externí odkaz:
https://doaj.org/article/1024de63458e48fd9c876cd83b1431e7