Evaluation of Vascular Endothelial Growth Factor (VEGF) and Its Family Member Expression After Peripheral Nerve Regeneration and Denervation

Autor: Luisa Muratori, A. Mancardi, Isabelle Perroteau, Stefano Geuna, S. Gnavi, Federica Fregnan, Stefania Raimondo

Publikováno v: The Anatomical Record. 301:1646-1656

Vascular endothelial growth factor (VEGF) represents one of the main factors involved not only in angiogenesis and vasculogenesis but also in neuritogenesis. VEGF plays its function acting via different receptors: VEGF receptor1 (VEGFR-1), VEGF recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ebf4782f3b3b5a9c713eacf50a6635b
https://doi.org/10.1002/ar.23842

The Effect of Electrospun Gelatin Fibers Alignment on Schwann Cell and Axon Behavior and Organization in the Perspective of Artificial Nerve Design

Autor: Rossella Laurano, Gianluca Ciardelli, S. Gnavi, Stefano Geuna, Marco Zanetti, Benedetta Elena Fornasari, C. Tonda-Turo

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 6, Pp 12925-12942 (2015)
International Journal of Molecular Sciences
Volume 16
Issue 6
Pages 12925-12942

Electrospun fibrous substrates mimicking extracellular matrices can be prepared by electrospinning, yielding aligned fibrous matrices as internal fillers to manufacture artificial nerves. Gelatin aligned nano-fibers were prepared by electrospinning a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6efc82051928a3dfb11fe0ef411910
http://www.mdpi.com/1422-0067/16/6/12925

Development and characterization of novel agar and gelatin injectable hydrogel as filler for peripheral nerve guidance channels

Autor: Giovanna Gambarotta, Francesca Ruini, Emilia Gioffredi, Gianluca Ciardelli, Chiara Tonda-Turo, S. Gnavi, Valeria Chiono, Isabelle Perroteau

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 11:197-208

Injectable hydrogels are becoming of increasing interest in the field of tissue engineering thanks to their versatile properties and to the possibility of being injected into tissues or devices during surgery. In peripheral nerve tissue engineering,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63193ae248bab5c3c41cd885e96933aa
https://doi.org/10.1002/term.1902

Gene delivery to rat and human Schwann cells and nerve segments: a comparison of AAV 1-9 and lentiviral vectors

Autor: Martijn J. A. Malessy, Callan L. Attwell, Martijn R. Tannemaat, Stefan A. Hoyng, Joost Verhaagen, F. De Winter, S. Gnavi, L van Egmond

Publikováno v: Gene Therapy, 22(10), 767-780
Hoyng, S A, de Winter, F, Gnavi, S, van Egmond, L, Attwell, C L, Tannemaat, M R, Verhaagen, J & Malessy, M J A 2015, ' Gene delivery to rat and human Schwann cells and nerve segments: a comparison of AAV 1-9 and lentiviral vectors ', Gene Therapy, vol. 22, no. 10, pp. 767-780 . https://doi.org/10.1038/gt.2015.47
Gene Therapy, 22(10), 767-80. Nature Publishing Group
Gene Therapy, 22(10), 767-780. Nature Publishing Group

Schwann cells (SCs) in an injured peripheral nerve form pathways for regenerating axons. Although these cells initially support regeneration, SCs lose their pro-regenerative properties following a prolonged period of denervation. Gene transfer to SC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbd342cb3deb564130822efccf89718
https://doi.org/10.1038/gt.2015.47

A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF

Autor: Ralph de Boer, Fred De Winter, Martijn J. A. Malessy, Martijn R. Tannemaat, Joost Verhaagen, Lennard I. Boon, Stefan A. Hoyng, S. Gnavi, Laura Korvers

Publikováno v: Experimental Neurology, 261, 578-93. Academic Press
Experimental Neurology, 261, 578-593

The clinical outcome of microsurgical repair of an injured peripheral nerve with an autograft is suboptimal. A key question addressed here is: can axon regeneration through an autograft be further improved? In this article the impact of six neurotrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2012a940c8ab497eabee0d21d87ab145
https://pure.knaw.nl/portal/en/publications/a5c27e9f-3ee1-49e2-a6ca-1d8d8b70d91d