Zobrazeno 1 - 10
of 130
pro vyhledávání: '"S. Genade"'
Publikováno v:
Basic Research in Cardiology. 105:495-511
Activation of several protein kinases occurs during myocardial ischaemia and during subsequent reperfusion. In contrast to the intensive investigation into the significance of kinase activation in cardioprotection, relatively little is known about th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1fe99ecf1972838ea5aed1845d1ee9
https://doi.org/10.1007/s00395-010-0086-3
https://doi.org/10.1007/s00395-010-0086-3
Publikováno v:
Life Sciences. 84:838-846
Previous studies suggested that p38 MAPK activation during sustained myocardial ischaemia and reperfusion was harmful. We hypothesize that attenuation of p38MAPK activity via dephosphorylation by the dual-specificity phosphatase MKP-1 should be prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb05497821e50f73433345b40ee23b6b
https://doi.org/10.1016/j.lfs.2009.03.014
https://doi.org/10.1016/j.lfs.2009.03.014
Publikováno v:
Cardiovascular Drugs and Therapy. 22:3-17
Previous studies from our laboratory showed that activation of p38 MAPK is one of the triggers of ischaemic preconditioning. The signalling events downstream of p38 MAPK and their links to the putative final effectors of preconditioning are not clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768939d6d2236551395aaa92dc932307
https://doi.org/10.1007/s10557-007-6078-3
https://doi.org/10.1007/s10557-007-6078-3
Publikováno v:
Basic Research in Cardiology. 98:337-346
The search for the mechanism of preconditioning-induced cardioprotection has been hampered by controversial results obtained by workers using different animal species, experimental models, protocols and endpoints. The aim of this study was to evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b620806f6617106211acb6719c96f316
https://doi.org/10.1007/s00395-003-0427-6
https://doi.org/10.1007/s00395-003-0427-6
Publikováno v:
Cardiovascular Drugs and Therapy. 17:217-230
To further evaluate the significance of p38 MAPK as trigger or mediator in ischaemic preconditioning, anisomycin and SB 203580 were used to manipulate its activation status. Special attention was given to the concentration of the drugs and protocols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2db7ca9018d1a2129248c19075d36e7
https://doi.org/10.1023/a:1026116022552
https://doi.org/10.1023/a:1026116022552
Publikováno v:
Journal of Molecular and Cellular Cardiology. 33:769-778
The role of p38 mitogen-activated protein kinase (MAPK) in ischaemic preconditioning remains controversial. Since most previous studies focussed on events only during sustained ischaemia, the aim of this study was to establish the activation pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0ba9db7ab01031929a9b95c7229ef6
https://doi.org/10.1006/jmcc.2001.1347
https://doi.org/10.1006/jmcc.2001.1347
Publikováno v:
Cardiovascular Journal of Africa
Aim Obesity and type 2 diabetes present with two debilitating complications, namely, hypertension and heart disease. The dried and ground pods of Prosopis glandulosa (commonly known as the Honey mesquite tree) which is part of the Fabaceae (or legume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abd8b3ac5844b8ba0811d76c39e7effc
https://pubmed.ncbi.nlm.nih.gov/23612947
https://pubmed.ncbi.nlm.nih.gov/23612947
Publikováno v:
Experimental cell research. 317(10)
Ischemic cell injury leads to cell death. Three main morphologies have been described: apoptosis, cell death with autophagy and necrosis. Their inherent dynamic nature, a point of no return (PONR) and molecular overlap have been stressed. The relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f87f75af1932b4995be758953127283
https://pubmed.ncbi.nlm.nih.gov/21420401
https://pubmed.ncbi.nlm.nih.gov/21420401
Publikováno v:
Cardiovascular Journal of Africa
Summary Summary Exposure of the heart to one or more short episodes of ischaemia/reperfusion protects the heart against a subsequent prolonged period of ischaemia, as evidenced by a reduction in infarct size and an improvement in functional recovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ff29252d7b9a4e668507552f3d4480a
https://pubmed.ncbi.nlm.nih.gov/19287816
https://pubmed.ncbi.nlm.nih.gov/19287816
Publikováno v:
Journal of Molecular and Cellular Cardiology. 23:1271-1286
Evidence has recently been presented that myocardial ischaemia is associated with a significant increased mitochondrial cholesterol content, suggesting a redistribution of cholesterol within the ischaemic cell (Rouslin et al. 1980, 1982). The aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f726e336c200ece00356962ba0d96fc8
https://doi.org/10.1016/0022-2828(91)90084-y
https://doi.org/10.1016/0022-2828(91)90084-y