Zobrazeno 1 - 10
of 121
pro vyhledávání: '"S. Gauer"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
The 2023 annual meeting of the British Society for Haemostasis and Thrombosis (BSHT) was held in Birmingham, United Kingdom. The theme of this year's meeting was novel therapeutics and emerging technology. Here, the exciting research presented at the
Externí odkaz:
https://doaj.org/article/e021f5b227624fb7a9118eaf4440e269
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 20 (2022)
Thromboinflammation has become a topic of key interest in cardiovascular disease and the prevention of diabetes complications because of the interplay between thrombosis and inflammation in diabetes. Specifically, the significant risk of vascular thr
Externí odkaz:
https://doaj.org/article/90b662e53dd74622aa10bc57df47fb4f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Neutrophils and neutrophil extracellular traps (NETs) have been shown to be involved in coagulation. However, the interactions between neutrophils or NETs and fibrin(ogen) in clots, and the mechanisms behind these interactions are not yet fu
Externí odkaz:
https://doaj.org/article/6d8af3e1ea2342bb99fc1b951eeda736
Autor:
Alexandre Slater, Gina Perrella, Marie-Blanche Onselaer, Eleyna M Martin, Julia S Gauer, Rui-Gang Xu, Johan WM Heemskerk, Robert A S Ariëns, Steve P Watson
Publikováno v:
Platelets, Vol 30, Iss 3, Pp 281-289 (2019)
GPVI is the major signalling receptor for collagen on platelets. Dimerization of GPVI is required for collagen binding and initiation of signalling through the associated FcR-γ chain. Recently, fibrin and fibrinogen have been identified as ligands f
Externí odkaz:
https://doaj.org/article/e9a50144d2f442d5bc7eee4bda5fb401
Autor:
Julia S. Gauer, Cédric Duval, Rui-Gang Xu, Fraser L. Macrae, Helen R. McPherson, Christian Tiede, Darren Tomlinson, Steve P. Watson, Robert A.S. Ariëns
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:667-681
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e639c3fdd9593ca0b999827c68d5064
https://doi.org/10.1016/j.jtha.2022.09.004
https://doi.org/10.1016/j.jtha.2022.09.004
Autor:
Cédric Duval, Robert A. S. Ariëns, Rui-Gang Xu, Helen R. McPherson, Iain W. Manfield, Alexandre Slater, Steve P. Watson, Stephen R. Baker, Julia S. Gauer, Eleyna M. Martin, Arkadiusz Bonna
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: GPVI (glycoprotein VI) is a key molecular player in collagen-induced platelet signaling and aggregation. Recent evidence indicates that it also plays important role in platelet ag
Objective: GPVI (glycoprotein VI) is a key molecular player in collagen-induced platelet signaling and aggregation. Recent evidence indicates that it also plays important role in platelet ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364de8c6c649062c5b9fd9913ad664be
https://doi.org/10.1161/atvbaha.120.315030
https://doi.org/10.1161/atvbaha.120.315030
Autor:
Anna Aprile, Gianluca Damonte, Aldo Profumo, Annalisa Salis, Robert A. S. Ariëns, Mattia Rocco, Cédric Duval, Julia S. Gauer, Enrico Millo
Publikováno v:
Journal of Thrombosis and Haemostasis
Background Fibrin polymerization, following fibrinopeptides A and B (FpA, FpB) cleavage, relies on newly exposed α- and β-chains N-termini (GPR, GHR; A-, B-knobs, respectively) engaging preexistent a and b pockets in other fibrin(ogen) molecules'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913a8f7363e47e1c6d6824e9a5395c09
http://europepmc.org/articles/PMC7186824
http://europepmc.org/articles/PMC7186824
Autor:
Holly Foster, Clare Wilson, Julia S. Gauer, Rui-Gang Xu, Mark J. Howard, Iain W. Manfield, Robert Ariëns, Khalid Naseem, Lewis R. Vidler, Helen Philippou, Richard Foster
Publikováno v:
ACS Med Chem Lett
[Image: see text] The GPVI platelet receptor was recently validated as a safe antiplatelet target for the treatment of thrombosis using several peptidic modulators. In contrast, few weakly potent small-molecule GPVI antagonists have been reported. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2531592f1cfe91a9cc6e553d7f4e4b
https://europepmc.org/articles/PMC8842102/
https://europepmc.org/articles/PMC8842102/
Autor:
Eden M. Page, Nicoletta Riva, Helen Philippou, Alex Gatt, Julia S. Gauer, Michael Makris, Robert A. S. Ariëns
Publikováno v:
Research and Practice in Thrombosis and Haemostasis
Background: Abnormal clot structure has been identified in patients with thrombotic disorders. Anticoagulant therapy offers clear benefits for thrombosis prevention and treatment by reducing blood clot formation and size; nevertheless, there are limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65898e4b94a64376f9e90db76df29423
https://www.um.edu.mt/library/oar/handle/123456789/87269
https://www.um.edu.mt/library/oar/handle/123456789/87269
Autor:
Gina Perrella, Rui-Gang Xu, Robert A. S. Ariëns, Marie-Blanche Onselaer, Alexandre Slater, Johan W. M. Heemskerk, Eleyna M. Martin, Julia S. Gauer, Steve P. Watson
Publikováno v:
Platelets, 30(3), 281-289. Routledge/Taylor & Francis Group
GPVI is the major signalling receptor for collagen on platelets. Dimerization of GPVI is required for collagen binding and initiation of signalling through the associated FcR-gamma chain. Recently, fibrin and fibrinogen have been identified as ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224c5b3501dd9793a4af0adb3aebefd0
https://cris.maastrichtuniversity.nl/en/publications/7d6ee17f-98f2-46c7-82b4-710e484cb9ac
https://cris.maastrichtuniversity.nl/en/publications/7d6ee17f-98f2-46c7-82b4-710e484cb9ac