Zobrazeno 1 - 10
of 412
pro vyhledávání: '"S. Gail Eckhardt"'
Autor:
Nisha Holay, Alexander Somma, Mark Duchow, Milad Soleimani, Anna Capasso, Srividya Kottapalli, Joshua Rios, Uma Giri, Jennifer Diamond, Anna Schreiber, Anthony D. Piscopio, Carla Van Den Berg, S. Gail Eckhardt, Todd A. Triplett
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Histone deacetylase inhibitors (HDACi) are currently being explored for the treatment of both solid and hematological malignancies. Although originally thought to exert cytotoxic responses through tumor-intrinsic mechanisms by increasing expression o
Externí odkaz:
https://doaj.org/article/fb11b1e8367b473a9f32db554b699b48
Autor:
Anna R. Schreiber, Jodi A. Kagihara, Bradley R. Corr, S. Lindsey Davis, Christopher Lieu, Sunnie S. Kim, Antonio Jimeno, D. Ross Camidge, Jud Williams, Amy M. Heim, Anne Martin, John A. DeMattei, Nisha Holay, Todd A. Triplett, S. Gail Eckhardt, Kevin Litwiler, James Winkler, Anthony D. Piscopio, Jennifer R. Diamond
Publikováno v:
Cancers, Vol 16, Iss 1, p 91 (2023)
(1) Background: Histone deacetylases (HDACs) play a critical role in epigenetic signaling in cancer; however, available HDAC inhibitors have limited therapeutic windows and suboptimal pharmacokinetics (PK). This first-in-human phase I dose escalation
Externí odkaz:
https://doaj.org/article/451d3f14506a4c3c96f07402e100bfa1
Autor:
Julie Lang, Alexis D. Leal, Juan A. Marín-Jiménez, Sarah J. Hartman, Jeremy Shulman, Natalie M. Navarro, Matthew S. Lewis, Anna Capasso, Stacey M. Bagby, Bethlehem W. Yacob, Morgan MacBeth, Brian M. Freed, S. Gail Eckhardt, Kimberly Jordan, Patrick J. Blatchford, Roberta Pelanda, Christopher H. Lieu, Wells A. Messersmith, Todd M. Pitts
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Immune checkpoint inhibitors have been found to be effective in metastatic MSI-high colorectal cancers (CRC), however, have no efficacy in microsatellite stable (MSS) cancers, which comprise the majority of mCRC cases. Cabozantinib is a small molecul
Externí odkaz:
https://doaj.org/article/4e169c4be6074370bda2cb5901dfda6f
Autor:
John J. Tentler, Julie Lang, Anna Capasso, Deog Joong Kim, Ely Benaim, Young B. Lee, Andrew Eisen, Stacey M. Bagby, Sarah J. Hartman, Betelehem W. Yacob, Brian Gittleman, Todd M. Pitts, Roberta Pelanda, S. Gail Eckhardt, Jennifer R. Diamond
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited systemic treatment options. RX-5902 is a novel anti-cancer agent that inhibits phosphorylated-p68 and thus attenuates nuclear β-catenin sign
Externí odkaz:
https://doaj.org/article/1dcda43bbcb945d6ae883320daa5d648
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Pp 3-15 (2020)
Immunotherapy is a rapidly evolving treatment paradigm that holds promise to provide long-lasting survival benefits for patients with cancer. This promise, however, remains unfulfilled for the majority of patients with gastrointestinal (GI) cancers,
Externí odkaz:
https://doaj.org/article/0ec16298238d4c659aeae02c7d4a6da1
Autor:
Sarah J. Hartman, Stacey M. Bagby, Betelehem W. Yacob, Dennis M. Simmons, Morgan MacBeth, Christopher H. Lieu, S. Lindsey Davis, Alexis D. Leal, John J. Tentler, Jennifer R. Diamond, S. Gail Eckhardt, Wells A. Messersmith, Todd M. Pitts
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with high incidences of p53 mutations. AZD1775 (adavosertib, previously MK-1775) is a small molecule WEE1 inhibitor that abrogates the G2M checkpoint and can potentially synergize with
Externí odkaz:
https://doaj.org/article/3fd57b698eda4a68a4b0e9a0920a5bdc
Autor:
Juan A. Marín-Jiménez, Anna Capasso, Matthew S. Lewis, Stacey M. Bagby, Sarah J. Hartman, Jeremy Shulman, Natalie M. Navarro, Hui Yu, Chris J. Rivard, Xiaoguang Wang, Jessica C. Barkow, Degui Geng, Adwitiya Kar, Ashley Yingst, Dejene M. Tufa, James T. Dolan, Patrick J. Blatchford, Brian M. Freed, Raul M. Torres, Eduardo Davila, Jill E. Slansky, Roberta Pelanda, S. Gail Eckhardt, Wells A. Messersmith, Jennifer R. Diamond, Christopher H. Lieu, Michael R. Verneris, Jing H. Wang, Katja Kiseljak-Vassiliades, Todd M. Pitts, Julie Lang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Over the past decade, immunotherapies have revolutionized the treatment of cancer. Although the success of immunotherapy is remarkable, it is still limited to a subset of patients. More than 1500 clinical trials are currently ongoing with a goal of i
Externí odkaz:
https://doaj.org/article/6424fe4cd62341bb904d284bc361adfc
Autor:
Woojung Shin, Alexander Wu, Soyoun Min, Yong Cheol Shin, R. Y. Declan Fleming, S. Gail Eckhardt, Hyun Jung Kim
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101372- (2020)
Summary: In a conventional culture of three-dimensional human intestinal organoids, extracellular matrix hydrogel has been used to provide a physical space for the growth and morphogenesis of organoids in the presence of exogenous morphogens such as
Externí odkaz:
https://doaj.org/article/d796b1ac37cb424ab58e2473ad1322ef
Autor:
Peter J. Klauck, Stacey M. Bagby, Anna Capasso, Erica L. Bradshaw-Pierce, Heather M. Selby, Anna Spreafico, John J. Tentler, Aik Choon Tan, Jihye Kim, John J. Arcaroli, Alicia Purkey, Wells A. Messersmith, Keisuke Kuida, S. Gail Eckhardt, Todd M. Pitts
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key regulator of multiple stages of mitotic progression. Plk1 is upregulated in many tumor types including colorectal cancer (CRC) and portends a poor prognosis. TAK
Externí odkaz:
https://doaj.org/article/d4dd779ae0964c9eb1a995ae2b3952c9
Autor:
Yong Cheol Shin, Woojung Shin, Domin Koh, Alexander Wu, Yoko M. Ambrosini, Soyoun Min, S. Gail Eckhardt, R. Y. Declan Fleming, Seung Kim, Sowon Park, Hong Koh, Tae Kyung Yoo, Hyun Jung Kim
Publikováno v:
Micromachines, Vol 11, Iss 7, p 663 (2020)
The regeneration of the mucosal interface of the human intestine is critical in the host–gut microbiome crosstalk associated with gastrointestinal diseases. The biopsy-derived intestinal organoids provide genetic information of patients with physio
Externí odkaz:
https://doaj.org/article/1f0717a4f6e84b20a7c83d0a152d77fd