Zobrazeno 1 - 10
of 26
pro vyhledávání: '"S. G. Zubova"'
Autor:
Valery A. Pospelov, Z. V. Chitikova, N. M. Yartseva, S. G. Zubova, Bykova Tv, Pospelova Tv, E. Y. Kochetkova
Publikováno v:
Cell and Tissue Biology. 15:370-380
Genomic instability and heterogeneity are the key features of cancer cells that allow their survival under environmental stress. A rapid accumulation of a large number of mutations in a single event due to a massive rearrangement of fragmented chromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2243cea0892ef376b2d941b3e4fccfcd
https://doi.org/10.1134/s1990519x2104009x
https://doi.org/10.1134/s1990519x2104009x
Autor:
Zh. V. Shitikova, Valery A. Pospelov, N. M. Yartseva, T. V. Bykova, S. G. Zubova, E. Yu. Kochetkova, Pospelova Tv
Publikováno v:
Cell and Tissue Biology. 15:248-259
Genome instability manifested by multiple reorganization contributes to the acquisition of new properties by tumor cells, resistance to therapy in particular. Structural rearrangements of chromosomes can be induced by damage to DNA, for example, by i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70e6b18507669e63b228e2339cf58958
https://doi.org/10.1134/s1990519x21030135
https://doi.org/10.1134/s1990519x21030135
Publikováno v:
Cell and Tissue Biology. 13:18-30
The karyotype and phenotype evolution in cell lines (Rapa) obtained by rapamycin selection from rat embryonic fibroblasts (REF) has been studied. Rapamycin, an inhibitor of mTORC1 kinase, prevents replicative aging of REF cells starting after seven t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18af400620b62cf3f984b8df75271389
https://doi.org/10.1134/s1990519x19010103
https://doi.org/10.1134/s1990519x19010103
Autor:
S. G. Zubova, E. Yu. Kochetkova, Pospelova Tv, T. V. Bykova, G. I. Blinova, Valery A. Pospelov
Publikováno v:
Cell and Tissue Biology. 11:268-274
Autophagy is a conserved process of protein and organelle degradation that serves to maintain cell viability. Autophagy is frequently induced in response to stress or to exposure to DNA-damaging agents or retinoids, as well as to starvation and defic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1890df5c8ae0fab15975d6e8f976767
https://doi.org/10.1134/s1990519x1704006x
https://doi.org/10.1134/s1990519x1704006x
Autor:
Valery A. Pospelov, M. G. Martynova, Serguei A. Gordeev, Tatiana V. Pospelova, O. A. Bystrova, S. G. Zubova, Bykova Tv
Publikováno v:
Oncotarget
mTOR is a critical target for controlling cell cycle progression, senescence and cell death in mammalian cancer cells. Here we studied the role of mTOR-dependent autophagy in implementating the antiprolifrative effect of mTORC1-specific inhibitor rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ef23bb4e313c968010538f029ceeac
https://doi.org/10.18632/oncotarget.6457
https://doi.org/10.18632/oncotarget.6457
Publikováno v:
Cells, Vol 9, Iss 1308, p 1308 (2020)
Cells
Cells
Throughout their life cycles, cells are subject to a variety of stresses that lead to a compromise between cell death and survival. Survival is partially provided by the cell proteostasis network, which consists of molecular chaperones, a ubiquitin-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afca59c7e2e813f91912895454250d66
https://doi.org/10.3390/cells9051308
https://doi.org/10.3390/cells9051308
Publikováno v:
Tsitologiia. 58(12)
Autophagy is a conservative process of misfolded protein and damaged organelle degradation that serves to support cellular viability. Autophagy is often induced in response to stress, DNA damage, retinoids, starvation and growth factor withdrawal. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26cfc47824fd49e448706cf224cab2ef
https://pubmed.ncbi.nlm.nih.gov/30188620
https://pubmed.ncbi.nlm.nih.gov/30188620
Publikováno v:
Tsitologiia. 38(12)
We have studied the dependence of cell viability on cell autophagy in control and senescent E1A+cHa-Ras transformed rat embryo fibroblasts. pp242, a TORC1/C2 kinase inhibitor, was used as a trigger of cell autophagy. Cell senescence was induced in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ab7c576d51389177be227d4df4783f59
https://pubmed.ncbi.nlm.nih.gov/30188621
https://pubmed.ncbi.nlm.nih.gov/30188621
Publikováno v:
Cell and Tissue Biology. 9:182-190
The role of the gene bcl-2 conferring resistance to apoptosis in the activation of the cellular senescence program induced by the histone deacetylase inhibitor (HDACi) sodium butyrate (NaBut) has been studied in transformed rat fibroblasts. The work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d5f111c72af5d72cc73dc0aa81cbde
https://doi.org/10.1134/s1990519x15030050
https://doi.org/10.1134/s1990519x15030050
Publikováno v:
Cell and Tissue Biology. 8:374-383
A key regulator of cellular senescence, mTORC1 complex, is a target of many signaling cascades, including Ras/Raf/MEK/ERK cascade. In this paper, we investigated the role of the MEK/ERK branch of this cascade in the process of cellular senescence ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b64403a096c04b3a60e8ad3f3f1848b
https://doi.org/10.1134/s1990519x14050034
https://doi.org/10.1134/s1990519x14050034