Zobrazeno 1 - 10
of 15
pro vyhledávání: '"S. G. Senderoff"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 43:1283-1288
A novel, selective approach to [O-methyl-14C]Dextromethorphan is presented. The key feature is protection of 3-hydroxymorphinan at nitrogen and oxygen with the vinyloxycarbonyl group. This allows selective O-deprotection and methylation without compe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d262172a4d0bf4bfe1537d85411429
https://doi.org/10.1002/1099-1344(200011)43:13<1283::aid-jlcr417>3.0.co
https://doi.org/10.1002/1099-1344(200011)43:13<1283::aid-jlcr417>3.0.co
Autor:
A. Y. L. Shu, D. Saunders, S. H. Levinson, S. W. Landvatter, A. Mahoney, S. G. Senderoff, J. F. Mack, J. R. Heys
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 42:797-807
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cb3b1bab363ac8a29b264fabd42527c
https://doi.org/10.1002/(sici)1099-1344(199908)42:8<797::aid-jlcr240>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199908)42:8<797::aid-jlcr240>3.0.co
Autor:
A. J. Villani, Arthur Y. L. Shu, S. G. Senderoff, Keith T. Garnes, D. Saunders, S. H. Levinson, J. R. Heys, W. Chen
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 39:291-298
The tritium exchange labeling of a variety of complex compounds is achieved in the presence of catalyst precursor [(cod)Ir(PPh 3 ) 1 ]BF 4 and limited amounts of tritium gas. The regioselectivity of exchange is high and consistent with empirical rule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4072daaedd76787702afca2ee8f44156
https://doi.org/10.1002/(sici)1099-1344(199704)39:4<291::aid-jlcr973>3.0.co
https://doi.org/10.1002/(sici)1099-1344(199704)39:4<291::aid-jlcr973>3.0.co
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 33:1091-1105
Carvedilol (SK&F 105517) possesses unique cardiovascular activity, and is under development for indications such as angina and hypertension. Tritium labeled enantiomers of Carvedilol and racemates of three metabolites were needed for pharmacologic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1d9a6d4b5835813e0cda86bab809a55
https://doi.org/10.1002/jlcr.2580331203
https://doi.org/10.1002/jlcr.2580331203
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 33:431-438
ABSTRACX Deuterium exchange labelling experiments were conducted on several series of compounds, including para-substituted benzoate esters, para-substituted N,N-dimethylbenzamides, and mono-para-substituted benzophenones, using [IrH2(MezC0)2(PPh3)2]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::026d71a9da5d25fb99fdfe11b63f78d9
https://doi.org/10.1002/jlcr.2580330509
https://doi.org/10.1002/jlcr.2580330509
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 31:519-538
Several Manoalide analogs, 4-(1-acetyloxyalkyl)-5-hydroxy-2(5H)-furanones labeled with carbon-14 in the alkyl side chain, were synthesized. The key step in these syntheses was singlet oxygenation of 2-trialkylsilyl-4-alkylfurans to give the correspon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3c00f7ae3be1e4ac1c21deb9a7641da
https://doi.org/10.1002/jlcr.2580310704
https://doi.org/10.1002/jlcr.2580310704
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 24:971-978
SK&F 86002, 6-(4-fluorophenyl)-5-(4-pyridyl)-2,3-dihydromidazo[2,1-b]thiazole, was synthesized labeled with carbon-14 at C-1 or C-2, 3 using either [14C]thiourea or 1,2-dibromo [14C2] ethane, respectively. The synthetic route, involving the condensat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8786a85e9c2fae4e23214e5b2e67641
https://doi.org/10.1002/jlcr.2580240812
https://doi.org/10.1002/jlcr.2580240812
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 27:841-849
1-[(3,5-Difluoro-4-hydroxyphenyl)methyl]-1,3-dihydro-2H-imidazole-2-thione, 1-[(3,5-difluoro-4-methoxyphenyl)methyl]-1,3-dihydro-2H-imidazole-2-thione, and 1-[(3,5-difluorophenyl)methyl]-1,3-dihydro-2H-imidazole-2-thione (SK&F 102048, SK&F 102055 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a51c7a0b3bd94b868ecec00a17377b8
https://doi.org/10.1002/jlcr.2580270713
https://doi.org/10.1002/jlcr.2580270713
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 24:389-396
Two amino acids, t-BOC-O-ethyl-D-tyrosine and t-BOC-phenylalanine, have been synthesized in tritium labeled form via exchange with tritium gas over catalyst on an unlabeled precursor and dehydrohalogenation on an iodinated precursor respectively. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd6f0856416db9d2e466b8183cb5a5b3
https://doi.org/10.1002/jlcr.2580240406
https://doi.org/10.1002/jlcr.2580240406
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 23(5)
An estrogen-receptor-binding radiopharmaceutical, 16 alpha-[77Br]bromoestradiol-17 beta, has been used successfully at high specific activity to image carcinogen-induced mammary tumors in rats and in preliminary studies to image breast tumors in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6d211ad40743f48616946b6ff5793f2
https://pubmed.ncbi.nlm.nih.gov/7077397
https://pubmed.ncbi.nlm.nih.gov/7077397