Výsledky vyhledávání - "S. G. Schafer"

A Second Generation of Centrally Acting Antihypertensive Agents Act on Putative I1-Imidazoline Receptors

Autor: K. L. Westbrooks, M. O. Christen, S. G. Schafer, Paul Ernsberger

Publikováno v: Journal of Cardiovascular Pharmacology. 20:S1-S10

Both the hypotension and the sedation elicited by centrally acting antihypertensive agents traditionally are ascribed to activation of α 2 -adrenergic receptors. However, second-generation centrally acting antihypertensive agents such as moxonidine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a939a1fac70442974b40dc992f96c7e5
https://doi.org/10.1097/00005344-199220004-00002

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Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla

Autor: Musa A. Haxhiu, S. G. Schafer, Paul Ernsberger, Ismail A. Dreshaj

Publikováno v: Journal of cardiovascular pharmacology. 24

The rostral ventrolateral medulla (RVLM) is the primary region maintaining vasomotor tone, and a site of action for central antihypertensive agents. In vitro [125I]p-iodoclonidine binding studies showed that moxonidine was selective for I1-imidazolin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6652340c01f4bd6cf89de463d39781bf
https://pubmed.ncbi.nlm.nih.gov/7533221

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