Zobrazeno 1 - 6
of 6
pro vyhledávání: '"S. G. Jezequel"'
Autor:
I. J. Higgins, S. G. Jezequel
Publikováno v:
Journal of Chemical Technology and Biotechnology. Biotechnology. 33:139-144
Mechanistic aspects of the mode of action of the soluble monooxygenase system of Methylosinus trichosporium OB3b have been investigated. The hydroxylation of 4-deuteroanisole in the 4-position was shown to proceed via an NIH shift with a deuterium re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b60661297be7bf233d0aad8a7a37e82
https://doi.org/10.1002/jctb.280330303
https://doi.org/10.1002/jctb.280330303
Autor:
D. K. Walker, Dennis A. Smith, S. Cole, Pierre Comby, Angus N. R. Nedderman, S. J. Roffey, S. G. Jezequel, N. Wood, D. Gibson
Publikováno v:
Drug Metabolism and Disposition. 31:731-741
Voriconazole is a new triazole antifungal agent with potent, wide-spectrum activity. Its pharmacokinetics and metabolism have been studied in mouse, rat, rabbit, dog, guinea pig, and humans after single and multiple administration by both oral and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f088a764c97c96ecb6744f1a12911d77
https://doi.org/10.1124/dmd.31.6.731
https://doi.org/10.1124/dmd.31.6.731
Publikováno v:
International journal of clinical pharmacology and therapeutics. 36(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10f30bdd8160edb24ca4745999e408ee
https://pubmed.ncbi.nlm.nih.gov/9520152
https://pubmed.ncbi.nlm.nih.gov/9520152
Autor:
D. K. Walker, S. G. Jezequel, D. A. Stopher, Kevin Beaumont, N J Cussans, M J Humphrey, David J. Rance, D. A. Smith
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(9-10)
1. Bioanalysis is traditionally associated with the development phase of drugs; its use in discovery programmes is often ignored but can have a major impact. 2. Pharmacokinetic studies conducted in conjunction with pharmacology screening can provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1fc3f2a1ba146b98cb1c7849132cab
https://pubmed.ncbi.nlm.nih.gov/1441610
https://pubmed.ncbi.nlm.nih.gov/1441610
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(4)
The disposition and metabolism of 14C-labeled fluconazole (100 microCi) was determined in three healthy male subjects after administration of a single oral capsule containing 50 mg of drug. Blood samples, total voided urine, and feces were collected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9205295d3e03dd541dee5920ac003d3
https://pubmed.ncbi.nlm.nih.gov/1680653
https://pubmed.ncbi.nlm.nih.gov/1680653
Publikováno v:
Biotechnology Letters. 6:567-570
Cell-free extracts of Methylosinus trichosporium 0B3b (MT 0B3b) containing the soluble, broad specificity methane mono-oxygenase (MMO) have been shown to catalyse yet another type of reaction : O-dealkylation. Several 4-substituted anisoles were inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fed707ae6e85b214cbfe6881cb8cfbdd
https://doi.org/10.1007/bf00135683
https://doi.org/10.1007/bf00135683