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Neural stem cell proliferation is decreased in schizophrenia, but not in depression

Autor: Andreas Reif, Alexander Strobel, M. Finger, Schmitt A, S. Fritzen, Martin Lauer, Klaus-Peter Lesch

Publikováno v: Molecular Psychiatry. 11:514-522

The phenomenon of adult neurogenesis (AN), that is, the generation of functional neurons from neural stem cells in the dentate gyrus of the hippocampus, has attracted remarkable attention, especially as it was shown that this process is also active i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e0ee01cc1e31306bf8c1766c4c9630
https://doi.org/10.1038/sj.mp.4001791

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Behavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals

Autor: Kittel S, Manfred Gerlach, Gass P, Golfier G, Edna Grünblatt, Andreas Reif, K.P. Lesch, S. Fritzen, Lise Gutknecht, Chizat F, Thomas Wultsch, Angelika Schmitt, S. Chourbaji

Publikováno v: Journal of Neural Transmission. Supplementa ISBN: 9783211735732

The gaseous messenger nitric oxide (NO) has been implicated in a wide range of behaviors, including aggression, anxiety, depression, and cognitive functioning. To further elucidate the physiological role of NO and its down-stream mechanisms, we condu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::357daa5355964c3d3a693fe5ed31a277
https://doi.org/10.1007/978-3-211-73574-9_10

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Adult neurogenesis in serotonin transporter deficient mice

Autor: Jens Benninghoff, Michel Hamon, Rainald Moessner, C. Doenitz, M. Rizzi, Angela Gritti, Eleni Paizanis, S. Gross, Angelika Schmitt, S. Fritzen, Angelo Vescovi, Andreas Reif, Laurence Lanfumey, M. Hermann, Dennis L. Murphy, K.P. Lesch

Publikováno v: Journal of Neural Transmission
Journal of Neural Transmission, Springer Verlag, 2007, 114 (9), pp.1107-19. 〈10.1007/s00702-007-0724-6〉
Journal of Neural Transmission, Springer Verlag, 2007, 114 (9), pp.1107-19. ⟨10.1007/s00702-007-0724-6⟩

International audience; Serotonin (5-HT) is a regulator of morphogenetic activities during early brain development and neurogenesis, including cell proliferation, migration, differentiation, and synaptogenesis. The 5-HT transporter (5-HTT, SLC6A4) me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f7f1f9a4a1204ad0618875bb976f95
https://pubmed.ncbi.nlm.nih.gov/17510734

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Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF

Autor: Claudia Sommer, Andreas Reif, Katharina Köth, Klaus-Peter Lesch, Angelika Schmitt, S. Fritzen

Publikováno v: Molecular and cellular neurosciences. 35(2)

Investigations regarding the regulation of adult neurogenesis, i.e., the generation of new neurons from progenitor cells, have revealed a high degree of complexity. Although the pleiotropic messenger molecule nitric oxide (NO) has been suggested to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e5f4d0708e4a22af5295ab4d47bcc0
https://pubmed.ncbi.nlm.nih.gov/17459722

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NO synthase-positive striatal interneurons are decreased in schizophrenia

Autor: T. Töpner, S. Fritzen, Alexander Strobel, K.P. Lesch, Andreas Reif, Angelika Schmitt, Martin Lauer

Publikováno v: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 17(9)

The gaseous messenger NO has repeatedly been suggested to play a role in the pathogenesis of psychoses. Following a pilot study, we investigated whether the number of nitrinergic neurons in the putamen of patients suffering from schizophrenia, bipola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae68f4befdaa3d333050cc111ff78ed
https://pubmed.ncbi.nlm.nih.gov/17267181

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A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function

Autor: Sabine Herterich, Thomas F. Wienker, K.P. Lesch, Ulrich Walter, Christian Jacob, Ann-Christine Ehlis, Saur D, Alexander Strobel, S. Fritzen, Schmitt A, T. Töpner, Andreas Reif, Andreas J. Fallgatter

Publikováno v: Molecular psychiatry. 11(3)

Nitric oxide (NO) is a gaseous neurotransmitter thought to play important roles in several behavioral domains. On a neurobiological level, NO acts as the second messenger of the N-methyl-D-aspartate receptor and interacts with both the dopaminergic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034989de71d50021d53308671d6cef12
https://pubmed.ncbi.nlm.nih.gov/16389274

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Morphological abnormalities in nitric-oxide-synthase-positive striatal interneurons of schizophrenic patients

Autor: Silvia Johannes, S. Fritzen, Martin Lauer, Peter Riederer, Dieter Senitz, Andreas Reif

Publikováno v: Neuropsychobiology. 52(3)

Schizophrenia has been suggested to be a neurodevelopmental disorder, and nitric-oxide-synthase (NOS)-positive neurons were shown to be involved in distorted cortical development in schizophrenia. Here we investigated whether nitrinergic neurons in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c032e187cf2292030ebd0a404ae0ad
https://pubmed.ncbi.nlm.nih.gov/16110244

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