Zobrazeno 1 - 10
of 186
pro vyhledávání: '"S. Frese"'
NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart
Autor:
Marion Müller, Rose Eghbalian, Jes-Niels Boeckel, Karen S. Frese, Jan Haas, Elham Kayvanpour, Farbod Sedaghat-Hamedani, Maximilian K. Lackner, Oguz F. Tugrul, Thomas Ruppert, Rewati Tappu, Diana Martins Bordalo, Jasmin M. Kneuer, Annika Piekarek, Sabine Herch, Sarah Schudy, Andreas Keller, Nadja Grammes, Cornelius Bischof, Anna Klinke, Margarida Cardoso-Moreira, Henrik Kaessmann, Hugo A. Katus, Norbert Frey, Lars M. Steinmetz, Benjamin Meder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Phosphorylation of the essential myosin light chain (ELC) influence actin-myosin crossbridge cycling in the heart. Here, the authors show upregulated ELC-phosphorylation in systolic heart failure and identify NIMArelated kinase 9 to bind to ELC media
Externí odkaz:
https://doaj.org/article/bdd3c98ae2ae446c8307d5af259ac8e7
Autor:
Jan Haas, Stefan Mester, Alan Lai, Karen S Frese, Farbod Sedaghat‐Hamedani, Elham Kayvanpour, Tobias Rausch, Rouven Nietsch, Jes‐Niels Boeckel, Avisha Carstensen, Mirko Völkers, Carsten Dietrich, Dietmar Pils, Ali Amr, Daniel B Holzer, Diana Martins Bordalo, Daniel Oehler, Tanja Weis, Derliz Mereles, Sebastian Buss, Eva Riechert, Emil Wirsz, Maximilian Wuerstle, Jan O Korbel, Andreas Keller, Hugo A Katus, Andreas E Posch, Benjamin Meder
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 107-120 (2017)
Abstract The transcriptome needs to be tightly regulated by mechanisms that include transcription factors, enhancers, and repressors as well as non‐coding RNAs. Besides this dynamic regulation, a large part of phenotypic variability of eukaryotes i
Externí odkaz:
https://doaj.org/article/4481e23c5007408586f68c9d973d8b8f
Autor:
Jan Haas, Karen S. Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Rewati Tappu, Rouven Nietsch, Oguz Firat Tugrul, Michael Wisdom, Carsten Dietrich, Ali Amr, Tanja Weis, Torsten Niederdränk, Michael P. Murphy, Thomas Krieg, Marcus Dörr, Uwe Völker, Jens Fielitz, Norbert Frey, Stephan B. Felix, Andreas Keller, Hugo A. Katus, Benjamin Meder
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1999 (2021)
With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi
Externí odkaz:
https://doaj.org/article/1ebb8fc853c64d13a283784499e3262b
Autor:
Rouven Nietsch, Jan Haas, Alan Lai, Daniel Oehler, Stefan Mester, Karen S. Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Andreas Keller, Benjamin Meder
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 14, Iss 4, Pp 200-206 (2016)
Next-generation sequencing (NGS) is getting routinely used in the diagnosis of hereditary diseases, such as human cardiomyopathies. Hence, it is of utter importance to secure high quality sequencing data, enabling the identification of disease-releva
Externí odkaz:
https://doaj.org/article/a4fb32f8ff114e5cba8ac31017d77886
Publikováno v:
Scandinavian Journal of Rheumatology. 51:237-240
Objective To evaluate the safety and effects of irinotecan, an inhibitor of topoisomerase I, on refractory lupus nephritis. Method A patient with refractory lupus nephritis under medication with mycophenolic acid, prednisolone, and hydroxychloroquine
Autor:
S Frese
Publikováno v:
31. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie.
Autor:
Annika Krämer, Ali Amr, Michael Backes, Karen S. Frese, Hans-Ulrich Prokosch, Dominique Schröder, Hugo A. Katus, Benjamin Meder, Christoph Egger, Ninja Marnau, Norbert Frey, Andreas Keller, Dominic Deuber, Claudia Durand, Farbod Sedaghat-Hamedani, Marc Schweig, Marc Hinderer, Lena Griebel, Jan Haas, Florian Battke, Elham Kayvanpour, Daniel Huhn
Background The development of Precision Medicine strategies requires high-dimensional phenotypic and genomic data, both of which are highly privacy-sensitive data types. Conventional data management systems lack the capabilities to sufficiently handl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd65493d11048efb939471096e423fe0
https://opus4.kobv.de/opus4-fau/files/22069/s00392-021-01942-8.pdf
https://opus4.kobv.de/opus4-fau/files/22069/s00392-021-01942-8.pdf
Publikováno v:
Biology, Vol 2, Iss 1, Pp 378-398 (2013)
Within just a few years, the new methods for high-throughput next-generation sequencing have generated completely novel insights into the heritability and pathophysiology of human disease. In this review, we wish to highlight the benefits of the curr
Externí odkaz:
https://doaj.org/article/01fd71425b4c4f31b872fc1661a16c9a
Autor:
Omid Shirvani Samani, Johannes Scherr, Elham Kayvanpour, Jan Haas, David H. Lehmann, Weng-Tein Gi, Karen S. Frese, Rouven Nietsch, Tobias Fehlmann, Steffi Sandke, Tanja Weis, Andreas Keller, Hugo A. Katus, Martin Halle, Norbert Frey, Benjamin Meder, Farbod Sedaghat-Hamedani
Publikováno v:
Journal of Clinical Medicine; Volume 11; Issue 1; Pages: 5
Journal of Clinical Medicine, Vol 11, Iss 5, p 5 (2022)
Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 11, Iss 5, p 5 (2022)
Journal of Clinical Medicine
Background: The current gold standard biomarker for myocardial infarction (MI), cardiac troponin (cTn), is recognized for its high sensitivity and organ specificity; however, it lacks diagnostic specificity. Numerous studies have introduced circulati
Autor:
Elham Kayvanpour, Tommaso Mansi, Farbod Sedaghat-Hamedani, Ali Amr, Dominik Neumann, Bogdan Georgescu, Philipp Seegerer, Ali Kamen, Jan Haas, Karen S Frese, Maria Irawati, Emil Wirsz, Vanessa King, Sebastian Buss, Derliz Mereles, Edgar Zitron, Andreas Keller, Hugo A Katus, Dorin Comaniciu, Benjamin Meder
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134869 (2015)
BackgroundDespite modern pharmacotherapy and advanced implantable cardiac devices, overall prognosis and quality of life of HF patients remain poor. This is in part due to insufficient patient stratification and lack of individualized therapy plannin
Externí odkaz:
https://doaj.org/article/75a79ff86b6844389777c8e0d5d75010