Zobrazeno 1 - 10
of 279
pro vyhledávání: '"S. Freestone"'
Publikováno v:
Journal of Neurochemistry. 162:417-429
A distinct population of dopamine neurons in the substantia nigra pars lateralis (SNL) has a unique projection to the most caudolateral (tail) region of the striatum. Here, using two electrochemical techniques to measure basal dopamine and electrical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb02e0f8ae9e07330320658e794aa27
https://doi.org/10.1111/jnc.15677
https://doi.org/10.1111/jnc.15677
Autor:
Jordan T. Lloyd, Andrew G. Yee, Prasanna K. Kalligappa, Anower Jabed, Pang Y. Cheung, Kathryn L. Todd, Rashika N. Karunasinghe, Srdjan M. Vlajkovic, Peter S. Freestone, Janusz Lipski
Publikováno v:
Neuroscience. 491
Under normal conditions, dopamine (DA) clearance after release largely depends on uptake by the DA transporter (DAT). DAT expression/activity is reduced in some neuropsychiatric and neurological disorders. Our aim was to characterize the behavioral,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5365b676f586ea73aec8553fda5f34b
https://pubmed.ncbi.nlm.nih.gov/35331847
https://pubmed.ncbi.nlm.nih.gov/35331847
Autor:
Pang Ying Cheung, Blaze Forbes, Peter S. Freestone, Andrew G. Yee, Mark H. Burrell, Janusz Lipski, Alessandro Martini
Publikováno v:
Journal of Neurochemistry. 148:462-479
Despite the importance of somatodendritic dopamine (DA) release in the Substantia Nigra pars compacta (SNc), its mechanism remains poorly understood. Using a novel approach combining fast-scan controlled-adsorption voltammetry (FSCAV) and single-unit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610acd34ded04e610ec459e6cc26885b
https://doi.org/10.1111/jnc.14587
https://doi.org/10.1111/jnc.14587
Autor:
Peter S. Freestone, Daniel McCormick, Fu-Yu Beverly Chen, Simon C. Malpas, Yuhui Sun, David Budgett
Publikováno v:
IEEE Transactions on Biomedical Circuits and Systems. 11:28-34
Optogenetics allows control of neuronal activity with unprecedented spatiotemporal precision, and has enabled both significant advances in neuroscience and promising clinical prospects for some neurological, cardiac, and sensory disorders. The abilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa74912e5e63c127736fc998fdb733e
https://doi.org/10.1109/tbcas.2016.2577042
https://doi.org/10.1109/tbcas.2016.2577042
Autor:
Janusz Lipski, Peter S. Freestone, Alice McDouall, Jordan T. Lloyd, Nicola Biagio Mercuri, Alessandro Martini, Rahul Sood
Publikováno v:
Neuroscience. 396
Extracellular levels of dopamine (DA) and other monoamines in the brain depend not only on the classic transporters encoded by SLC6A gene family such as DAT, NET and SERT, but also a more recently identified group of low-affinity/high-capacity 'Uptak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d078705eee4bfecd1ebadc5f243de4
https://pubmed.ncbi.nlm.nih.gov/30447392
https://pubmed.ncbi.nlm.nih.gov/30447392
Publikováno v:
European Journal of Pharmacology. 767:144-151
Endocannabinoids (eCBs) are cannabis-like substances produced in the brain where their primary function is to regulate synaptic transmission by inhibiting neurotransmitter release in a retrograde fashion. We have recently demonstrated a novel mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27e3ef7847cb5a182db254fbec601c3
https://doi.org/10.1016/j.ejphar.2015.09.050
https://doi.org/10.1016/j.ejphar.2015.09.050
Autor:
Todd S. Freestone, Huimin Zhao
Publikováno v:
Biotechnology and Bioengineering. 113:384-392
As resistance to current anti-malarial therapeutics spreads, new compounds to treat malaria are increasingly needed. One promising compound is FR900098, a naturally occurring phosphonate. Due to limitations in both chemical synthesis and biosynthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daf4c6fc086acdb2d6ab8c3ee7fb2516
https://doi.org/10.1002/bit.25719
https://doi.org/10.1002/bit.25719
Autor:
Ilva D. Rupenthal, Louise F.B. Nicholson, Helen V. Danesh-Meyer, Colin R. Green, Yeri Kim, Simon J. O'Carroll, Jarred M. Griffin, Jie Zhang, Peter S. Freestone, Monica L. Acosta, Mohd N Mat Nor
Publikováno v:
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 14(4)
The cis benzopyran compound tonabersat (SB-220453) has previously been reported to inhibit connexin26 expression in the brain by attenuating the p38-mitogen-activated protein kinase pathway. We show here that tonabersat directly inhibits connexin43 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c71e12fc0f7d1742ed7fc48a657957b
https://pubmed.ncbi.nlm.nih.gov/28560708
https://pubmed.ncbi.nlm.nih.gov/28560708
Publikováno v:
ACS synthetic biology. 6(2)
The activation of silent natural product gene clusters is a synthetic biology problem of great interest. As the rate at which gene clusters are identified outpaces the discovery rate of new molecules, this unknown chemical space is rapidly growing, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5a654830cdf8c184d06a552f63cc20
https://pubmed.ncbi.nlm.nih.gov/28103011
https://pubmed.ncbi.nlm.nih.gov/28103011
Publikováno v:
Experimental neurology. 287(Pt 1)
Parkinson's disease (PD) is not only associated with degeneration of dopaminergic (DAergic) neurons in the Substantia Nigra, but also with profound loss of noradrenergic neurons in the Locus Coeruleus (LC). Remarkably, LC degeneration may exceed, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98f8f0f7ca59f51ecd44d924e3c1ddf
https://pubmed.ncbi.nlm.nih.gov/27771354
https://pubmed.ncbi.nlm.nih.gov/27771354