Zobrazeno 1 - 10
of 139
pro vyhledávání: '"S. Florjancic"'
Autor:
Andrew J. Souers, Wei Qiu, Thomas D. Penning, Darren C. Phillips, Xiaoqin Liu, Rick F. Clark, Joel D. Leverson, Amanda M. Olson, Chunqiu Lai, Daniel H. Albert, Gui-Dong Zhu, Yunsong Tong, Peter Kovar, Kenton L. Longenecker, Anthony Mastracchio, Morey L. Smith, Bailin Shaw, Alan S. Florjancic, Stephen K. Tahir, Donald J. Osterling
Publikováno v:
ACS Med Chem Lett
[Image: see text] Cyclin-dependent kinase 9 (CDK9) is a serine/threonine kinase involved in the regulation of transcription elongation. An inhibition of CDK9 downregulates a number of short-lived proteins responsible for tumor maintenance and surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85e60b25f3e832de4e347a9da8d597e
https://doi.org/10.1021/acsmedchemlett.1c00161
https://doi.org/10.1021/acsmedchemlett.1c00161
Publikováno v:
International Journal of Rotating Machinery, Vol 5, Iss 3, Pp 219-230 (1999)
The resolve of journal bearing field problems and the full vibrational assessment of an industrial gas turbine, simple cycle rotor train, ABB’s GTllN2 is presented. Three units experienced several times damage of the journal bearings on the compres
Externí odkaz:
https://doaj.org/article/8b509ee414ff4dc1a3a5379a76c4060a
Publikováno v:
Volume 3: Coal, Biomass, and Alternative Fuels; Cycle Innovations; Electric Power; Industrial and Cogeneration; Organic Rankine Cycle Power Systems.
The operating conditions of the gas turbine combined cycle (GTCC) power plants have significantly changed over the last few years and are directed towards an improved operational and fuel flexibility, increased GT power output and efficiency and impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df66b11a867b5127ad45f7426a628ed2
https://doi.org/10.1115/gt2018-76665
https://doi.org/10.1115/gt2018-76665
Publikováno v:
Volume 3: Coal, Biomass and Alternative Fuels; Cycle Innovations; Electric Power; Industrial and Cogeneration Applications; Organic Rankine Cycle Power Systems.
This paper provides an overview of the ongoing development activities for the Ansaldo Energia gas turbines AE64.3A, AE94.2, AE94.2K, AE94.3A, GT26 (2006), GT26 (2011), GT36-S6 and GT36-S5. The improvements significantly reduce the energy consumption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6eeff4edaad21a73c9318ddbf7d6a06
https://doi.org/10.1115/gt2017-64893
https://doi.org/10.1115/gt2017-64893
Autor:
Philip J. Merta, Amanda M. Olson, Fritz G. Buchanan, Nirupama B. Soni, Donald J. Osterling, Alan S. Florjancic, Debra Ferguson, David Maag, Eric F. Johnson, Yunsong Tong, Alexander R. Shoemaker, Maricel Torrent, Kenneth D. Bromberg, Thomas D. Penning, Loren M. Lasko
Publikováno v:
ACS Medicinal Chemistry Letters. 6:58-62
Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure-activity studies identified key pharmacophores at the aminoaryl and halo-benzene regions responsible for b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b451c835e91d1f244b2b91708eb295
https://doi.org/10.1021/ml5002745
https://doi.org/10.1021/ml5002745
Autor:
Kerren K. Swinger, Magdalena Przytulinska, Yunsong Tong, Alan S. Florjancic, Eric F. Johnson, Philip J. Merta, Kent D. Stewart, Thomas D. Penning, Nirupama B. Soni, Alexander R. Shoemaker, John E. Harlan, Haizhong Zhu
Publikováno v:
ACS Medicinal Chemistry Letters. 4:211-215
To investigate the role played by the unique pre-DFG residue Val 195 of Cdc7 kinase on the potency of azaindole-chloropyridines (1), a series of novel analogues with various chloro replacements were synthesized and evaluated for their inhibitory acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d5106adb466152cb74c85ee58f5d7b
https://doi.org/10.1021/ml300348c
https://doi.org/10.1021/ml300348c
Autor:
B B Yao, William A. Carroll, Jennifer M. Frost, Madhavi Pai, George K. Grayson, Chang Zhu, Bradley A. Hooker, Alan S. Florjancic, Karin R. Tietje, Michael Meyer, Anthony V. Daza, Michael J. Dart, Tiffany Runyan Garrison, Derek W. Nelson, Keith B. Ryther, Gin C. Hsieh, Prasant Chandran, Odile F. El-Kouhen, Yihong Fan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2604-2608
SAR studies on a series of thiophene amide derivatives provided CB(2) receptor agonists. The activity of the compounds was characterized by radioligand binding determination, multiple functional assays, ADME, and pharmacokinetic studies. A representa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cec3e6fc78e745dc4ab01db88eb9d1
https://doi.org/10.1016/j.bmcl.2012.01.121
https://doi.org/10.1016/j.bmcl.2012.01.121
Autor:
Niru B. Soni, Eric F. Johnson, Joel D. Leverson, Thomas D. Penning, Keith W. Woods, Yan Shi, Loren M. Lasko, Julie M. Miyashiro, Alan S. Florjancic, E. K.-H. Han, Chunqiu Lai, Alexander R. Shoemaker, Yunsong Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1940-1943
We have investigated the SAR of a series of pyrimidinone-containing Cdc7 kinase inhibitors. A wide range of amine substitutions give potent compounds with activities (K(i)) less than 1nM. Kinase selectivity is reasonable and cytotoxicity corresponds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf3f74c76d9ced20f6761e60f152a42
https://doi.org/10.1016/j.bmcl.2012.01.041
https://doi.org/10.1016/j.bmcl.2012.01.041
Autor:
Sridhar Peddi, Diana L. Donnelly-Roberts, Connie R. Faltynek, Arturo Perez-Medrano, Derek W. Nelson, Tongmei Li, Alan S. Florjancic, William A. Carroll, Michael F. Jarvis, Marian T. Namovic
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3297-3300
Synthesis and biological evaluation of a novel class of substituted N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine derivatives resulted in the identification of potent P2X7 antagonists. These compounds were assayed for activity at both the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683e04fd57c19abe464f0206f2e5483b
https://doi.org/10.1016/j.bmcl.2011.04.024
https://doi.org/10.1016/j.bmcl.2011.04.024
Autor:
Alan S. Florjancic, William A. Carroll, Michael F. Jarvis, Marian T. Namovic, Biqin Li, Diana L. Donnelly-Roberts, Arturo Perez-Medrano, Sridhar Peddi, George K. Grayson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2089-2092
A novel series of aminotriazole-based P2X(7) antagonists was synthesized, and their structure-activity relationships (SAR) were investigated for activity at both human and rat P2X(7) receptors. Most compounds showed greater potency at the human recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22402cf6349dedffc9952f2f83203665
https://doi.org/10.1016/j.bmcl.2008.01.095
https://doi.org/10.1016/j.bmcl.2008.01.095