Zobrazeno 1 - 10 of 354 pro vyhledávání: '"S. Fenwick"'
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Akademický článek
IL-36 receptor agonist and antagonist imbalance drives neutrophilic inflammation in COPD
Autor: Jonathan R. Baker, Peter S. Fenwick, Carolin K. Koss, Harriet B. Owles, Sarah L. Elkin, Jay Fine, Matthew Thomas, Karim C. El Kasmi, Peter J. Barnes, Louise E. Donnelly
Publikováno v: JCI Insight, Vol 7, Iss 15 (2022)
Current treatments fail to modify the underlying pathophysiology and disease progression of chronic obstructive pulmonary disease (COPD), necessitating alternative therapies. Here, we show that COPD subjects have increased IL-36γ and decreased IL-36
Externí odkaz: https://doaj.org/article/bfbbfa894e21493c8e3cf8438e35c9e1
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2
Akademický článek
Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD
Autor: R. Singh, K. B. R. Belchamber, P. S. Fenwick, K. Chana, G. Donaldson, J. A. Wedzicha, P. J. Barnes, L. E. Donnelly, COPDMAP consortium
Publikováno v: Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Lower airway bacterial colonisation (LABC) in COPD patients is associated with increased exacerbation frequency and faster lung function decline. Defective macrophage phagocytosis in COPD drives inflammation, but how defective mac
Externí odkaz: https://doaj.org/article/100d24a891c14ece8c0df68509288966
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4
IL-36 receptor agonist and antagonist imbalance drives neutrophilic inflammation in COPD
Autor: Jonathan R. Baker, Peter S. Fenwick, Carolin K. Koss, Harriet B. Owles, Sarah L. Elkin, Jay Fine, Matthew Thomas, Karim C. El Kasmi, Peter J. Barnes, Louise E. Donnelly
Publikováno v: JCI insight. 7(15)
Current treatments fail to modify the underlying pathophysiology and disease progression of chronic obstructive pulmonary disease (COPD), necessitating alternative therapies. Here, we show that COPD subjects have increased IL-36γ and decreased IL-36
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059928190bd94e234af850a41c6e36a2
https://pubmed.ncbi.nlm.nih.gov/35763349
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5
Akademický článek
Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells.
Autor: Peter S Fenwick, Patricia Macedo, Iain C Kilty, Peter J Barnes, Louise E Donnelly
Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128757 (2015)
CD8+ T-cells are located in the small airways of COPD patients and may contribute to pathophysiology. CD8+ cells express the chemokine receptor, CXCR3 that binds CXCL9, CXCL10 and CXCL11, which are elevated in the airways of COPD patients. These chem
Externí odkaz: https://doaj.org/article/cf53f85432114bde9a72acd6c6e3d583
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6
Akademický článek
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8
Additional file 1 of Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD
Autor: R. Singh, K. B. R. Belchamber, P. S. Fenwick, K. Chana, G. Donaldson, J. A. Wedzicha, P. J. Barnes, Donnelly, L. E.
Additional file 1: Figure 1. Relationship between clinical demographics and MDM phagocytosis. (A) H. influenzae (B) S. pneumoniae showing age (years) (C) H. influenzae (D) S. pneumoniae showing FEV1% predicted. (E) H. influenzae (F) S. pneumoniae sho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6c9dacbcce6ee14fad988b22fd53a0
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9
Additional file 2 of Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD
Autor: R. Singh, K. B. R. Belchamber, P. S. Fenwick, K. Chana, G. Donaldson, J. A. Wedzicha, P. J. Barnes, Donnelly, L. E.
Additional file 2: Figure 2. The effect of different treatments on MDM phagocytosis. (A) H. influenzae (B) S. pneumoniae showing patients taking no ICS (n = 15), beclomethasone (BM, n = 4), budesonide (BU, n = 14) or fluticasone propionate (FP, n = 5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a1c37f29769dc190876c0c81fe42e9
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