Výsledky vyhledávání - "S. F. A. Weekx"

Generation of T cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-α

Autor: M. De Smedt, Z. N. Berneman, J. Plum, A C Moulijn, D. R. Van Bockstaele, I. Rodrigus, G. Nijs, M. Lenjou, Hans-Willem Snoeck, S. F. A. Weekx, F. Offner

Publikováno v: Blood

To investigate the T-lymphopoietic capacity of human adult bone marrow (ABM) hematopoietic progenitor cells, CD34+Lin-, CD34+CD38+, and CD34++CD38- cells were cultured in a severe combined immunodeficient (SCID) mouse fetal thymic organ culture (FTOC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5354f57a888a1becfccf828e0aea47e
https://doi.org/10.1182/blood.v95.9.2806.009k01_2806_2812

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Developmentally regulated responsiveness to transforming growth factor-β is correlated with functional differences between human adult and fetal primitive hematopoietic progenitor cells

Autor: P. Van Cauwelaert, M. De Smedt, M. Vanhove, Marc Lenjou, Zwi N. Berneman, P. Muylaert, Hans-Willem Snoeck, D. R. Van Bockstaele, S. F. A. Weekx, Griet Nijs, Jean Plum

Publikováno v: Leukemia

Important functional differences exist between primitive CD34++ CD38- hematopoietic progenitor cells derived from human fetal liver (FL) and adult bone marrow (ABM). FL progenitors are known to have higher proliferative capacities and lower cytokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b325794f08171b59ea8c6a3173cd81
https://hdl.handle.net/10067/268170151162165141

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Tumor necrosis factor \alpha$ is a potent synergistic factor for the proliferation of primitive human hematopoietic progenitor cells and induces resistance to transforming growth factor \beta$ but not to interferon \gamma$

Autor: H.-W. Snoeck, S. F. A. Weekx, P. C. F. Van Ranst, Filip Lardon, Zwi N. Berneman, D. R. Van Bockstaele, A. Moulijn, Marc Lenjou, G. Nys

Publikováno v: The journal of experimental medicine
The Journal of Experimental Medicine

Since tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and transforming growth factor (TGF)-beta have all been shown to be specific inhibitors of early human hematopoiesis, we wanted to investigate the interactions of these three cytokines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275c08bde1c493c4cd3bc50066d987c5
https://hdl.handle.net/10067/163670151162165141

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