Zobrazeno 1 - 10
of 22
pro vyhledávání: '"S. Esmail Tabibi"'
Autor:
S. Esmail Tabibi, Thomas R. Tice
Publikováno v:
Treatise on Controlled Drug Delivery ISBN: 9780203735022
This chapter highlights some of the key factors in designing and developing parenteral controlled-release dosage forms. It addresses some of the reasons why one would select a parenteral controlled-release dosage form over other controlled-release do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44d41d5f43ec978f552d8530e9f6444d
https://doi.org/10.1201/9780203735022-7
https://doi.org/10.1201/9780203735022-7
Autor:
Kelly L. Karlage, Paul B. Myrdal, Samuel H. Yalkowsky, Sean P. O’Connell, Travis J. Wissinger, S. Esmail Tabibi, Duoli Guo
Publikováno v:
AAPS PharmSciTech. 11:247-252
In vivo, the DNA methyltransferase inhibitor, 5-fluoro-2'-deoxycytidine (FdCyd, NSC-48006), is rapidly converted to its unwanted metabolites. Tetrahydrouridine (THU, NSC-112907), a cytidine deaminase inhibitor can block the first metabolic step in Fd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6788b718419242c2d4894f435c29c9d
https://doi.org/10.1208/s12249-010-9383-2
https://doi.org/10.1208/s12249-010-9383-2
Autor:
Parijat Jain, Ritesh Sanghvi, Paul B. Myrdal, Ryuichi Narazaki, Stephen G. Machatha, Elizabeth R. Glaze, S. Esmail Tabibi, Samuel H. Yalkowsky, Erik Mogalian, Kelly L. Karlage
Publikováno v:
Journal of Pharmaceutical Sciences. 98:205-214
The preformulation, solubilization and pharmacokinetic evaluation of antalarmin, a stress inhibitor, have been conducted. Antalarmin has a poor water solubility of less than 1µg/mL and is weakly basic with an experimentally determined p K a of 5.0.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9615399d95478e727505319b88d86d
https://doi.org/10.1002/jps.21421
https://doi.org/10.1002/jps.21421
Publikováno v:
Journal of Pharmaceutical Sciences. 95:97-107
The efficiency of a solubilization technique is determined by the physical-chemical properties of the drug. This study investigates the solubilization on two structurally related anticancer drugs, XK-469 and PPA. XK-469 is much less polar than PPA wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e420ad1683d98770652a80a5a0e71ca
https://doi.org/10.1002/jps.20500
https://doi.org/10.1002/jps.20500
Publikováno v:
Pharmaceutical Research. 19:115-123
Purpose To optimize the structure of geldanamycin (GDM) derivative moieties attached to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers via an enzymatically degradable spacer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36568a3755268f09b4fc95808eff9843
https://doi.org/10.1023/a:1014216712820
https://doi.org/10.1023/a:1014216712820
Publikováno v:
International Journal of Pharmaceutics. 160:21-29
Dansylation of the pentaamine pentaazapentacosane ·5 HCl (PAPC) produces only the perdansyl product. This occurs even under conditions of pH and dansyl chloride concentration most likely to produce partially dansylated products. This result is expla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::500744ded9b62f2f4655182091295d72
https://doi.org/10.1016/s0378-5173(97)00315-3
https://doi.org/10.1016/s0378-5173(97)00315-3
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 688:354-358
A simple and sensitive isocratic high-performance liquid chromatographic (HPLC) method with UV detection for the quantitation of perillic acid, a major circulating metabolite of perillyl alcohol and d-limonene, in plasma is described. Sample preparat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0e917bcce4522f783883e84411ac64
https://doi.org/10.1016/s0378-4347(96)00322-2
https://doi.org/10.1016/s0378-4347(96)00322-2
Autor:
William D. Figg, Sean P. O’Connell, James P. Cain, Erin R. Gardner, Samuel H. Yalkowsky, Duoli Guo, Steven Pisle, S. Esmail Tabibi
Publikováno v:
AAPS PharmSciTech. 13(2)
A stability-indicating high-performance liquid chromatography method to quantify 2-(2,4-difluorophenyl)-4,5,6,7-tetrafluoroisoindoline-1,3-dione (NSC-726796) and its three main degradation products was developed. This method was used to investigate i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db11c739cc5aaa46fff312915e4cf4c3
https://pubmed.ncbi.nlm.nih.gov/22552929
https://pubmed.ncbi.nlm.nih.gov/22552929
Publikováno v:
Journal of Pharmaceutical Sciences. 88:945-947
This study investigates the roles of both ionized and un-ionized species of flavopiridol in solubilization by complexation, micellization, and cosolvency. Control of pH was used in combination with surfactants (polysorbate 20 and polysorbate 80), cos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585e783d7e285ba0327ef1fab4e365fd
https://doi.org/10.1021/js990097r
https://doi.org/10.1021/js990097r
Publikováno v:
Journal of Pharmaceutical Sciences. 88:535-537
A spectrophotometric technique was used to determine the acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug. The apparent pKa values of Col-3 in 0.5% methanol aqueous media at approximately 25 degrees C with a constant io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642944d47cd63914b9f734e3c4cc22d9
https://doi.org/10.1021/js980398l
https://doi.org/10.1021/js980398l