Zobrazeno 1 - 10
of 52
pro vyhledávání: '"S. E. Tkachenko"'
Autor:
Ilya Okun, Oleg D. Mitkin, Madina G. Kadieva, S. E. Tkachenko, Elena S. Golovina, Alexandre V. Ivachtchenko
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:4614-4627
Substituted diphenyl sulfones (10a–n) were synthesised, and the structures were confirmed by NMR, LC–MS and X-ray crystallography. Their antagonistic activities towards 5-HT6 receptor were assessed in a cell-based functional assay. Diphenyl sulfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e08f5b2180dfe9917ccadbf4f5d8ce9
https://doi.org/10.1016/j.bmc.2013.05.040
https://doi.org/10.1016/j.bmc.2013.05.040
Publikováno v:
Russian Chemical Reviews. 79:285-306
Data on the methods of 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles synthesis has been surveyed. The synthetic accessibility of various derivatives of these heterocycles has been demonstrated. It has been shown that such compounds exhibit a broad spect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a9a12e3f1ec9d967dace956277b8f99
https://doi.org/10.1070/rc2010v079n04abeh004122
https://doi.org/10.1070/rc2010v079n04abeh004122
Autor:
Alexandre V. Ivachtchenko, Oleg Dmitrievich Mitkin, S. E. Tkachenko, Eugene B. Frolov, Alexandre V. Khvat
Publikováno v:
Chemistry of Heterocyclic Compounds. 46:170-178
A schemes have been proposed for the synthesis of novel 4-substituted 2,7-dimethyl-3,4-dihydro-1H- and previously unknown 2,7-dimethyl-cis-1,2,3,3a,4,8b-hexahydropyrrolo[3,4-b]indoles. In the case of the Dimebon structural analog 2,7-dimethyl-4-[2-(6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4912178ac58e997cc03a13e75cb0df76
https://doi.org/10.1007/s10593-010-0488-z
https://doi.org/10.1007/s10593-010-0488-z
Autor:
Oleg D. Mitkin, Alexandre Vasilievich Ivachtchenko, S. E. Tkachenko, Ilya Okun, V. I. Kazey, Alexander Viktorovich Khvat
Publikováno v:
Current Alzheimer Research. 7:97-112
Dimebon, originally developed as an anti-histamine drug, is being re-purposed for new indications as an effective treatment for patients suffering from Alzheimer's and Huntington's diseases, albeit with an as-yet unknown mechanism of action. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2108d032573c47bc7506292dd2ed025a
https://doi.org/10.2174/156720510790691100
https://doi.org/10.2174/156720510790691100
Publikováno v:
Drugs in R & D. 9:397-434
This 'state-of-the-art' review specifically focuses on alternative signalling pathways deeply involved in acute and chronic inflammatory responses initiated by various pathological stimuli. The accumulated scientific knowledge has already revealed ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0230f7ca9c4340649bede5faa32567
https://doi.org/10.2165/0126839-200809060-00005
https://doi.org/10.2165/0126839-200809060-00005
Autor:
Vladimir Y. Vvedensky, S. E. Tkachenko, Yury V. Ivanov, Volodymyr M. Kysil, Alexander S. Kiselyov, Caroline Williams, Alexander Viktorovich Khvat, Alexandre V. Ivachtchenko
Publikováno v:
Tetrahedron Letters. 46:3953-3956
Reaction of 3-(1-alkylamino)pyridines with electron deficient acetylenes in the presence of acids yields 1,2-dihydro[2,7]naphthyridine-3,4-dialkyldicarboxylates 4 in 35–72% yield. Compounds 4 unsubstituted in position 1 can be easily oxidized with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072d2caf9e76d9cccc6ae1ae615eabeb
https://doi.org/10.1016/j.tetlet.2005.04.053
https://doi.org/10.1016/j.tetlet.2005.04.053
Publikováno v:
Russian Journal of Organic Chemistry. 38:1149-1153
By reaction of aromatic aldehydes with ammonium acetate a series of 1,2-diaryl-1,2-diaminoethanes and their derivatives was obtained. The mechanism of reaction was suggested and its principal stages were proved. Reactions with ammonium acetate of aro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::035d83f5b4831b9a3fac9c0ef25adcb1
https://doi.org/10.1023/a:1020997325550
https://doi.org/10.1023/a:1020997325550
Publikováno v:
Chemistry of Heterocyclic Compounds. 36:1149-1153
A method has been developed for the synthesis of isosteric analogs of nicotine involving ethers of S(-)-1-2-pyrrolidinemethanol and S(-)-1-2-pyrrolidineethanol based on the Mitsunobu reaction. The results of testing the synthesized compounds as calci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2e1c801bcb716c4df2d213b7c713d3a
https://doi.org/10.1023/a:1002856330054
https://doi.org/10.1023/a:1002856330054
Publikováno v:
Chemistry of Heterocyclic Compounds. 35:973-977
Different synthetic routes to the preparation of 4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2,2,2]octane-1-thioxide labelled with sulfur-35 have been investigated since it is of considerable interest as radioligand for neurochemistry. The thiophosphate wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6475d569fc14d79fa909a345ff03bdb
https://doi.org/10.1007/bf02252166
https://doi.org/10.1007/bf02252166
Publikováno v:
Chemistry of Heterocyclic Compounds. 34:347-350
A convenient method is proposed for obtaining difficultly available derivatives of 2-amino-5-chloromethyl-2-thiazoline by the cyclization of N-allythioureas under the action ofα-chloronitrosoalkanes. It is assumed that the reaction proceeds as a hal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d331ab7f8a393a443d30b0f7018b574b
https://doi.org/10.1007/bf02290730
https://doi.org/10.1007/bf02290730