Zobrazeno 1 - 10
of 30
pro vyhledávání: '"S. E. Sosonyuk"'
Autor:
D. R. Bazanov, N. A. Maximova, M. Yu. Seliverstov, N. A. Zefirov, S. E. Sosonyuk, N. A. Lozinskaya
Publikováno v:
Russian Journal of Organic Chemistry. 57:1834-1840
Autor:
N. A. Lozinskaya, Egor V. Savin, Nikolay V. Pervushin, Anita I. Maksutova, Gelina S. Kopeina, Michael D. Tsymliakov, Daniil R. Bazanov, S. E. Sosonyuk
Publikováno v:
Medicinal Chemistry Research. 30:2216-2227
p53-MDM2/MDMX interaction inhibitors represent the prospective agents for targeted anticancer therapy in tumors expressing wild-type p53 protein. Imidazoline-based MDM2-targeted inhibitors of such type, nutlins, contain halogen-substituted phenyl rin
Autor:
Sergey A. Kuznetsov, Natalia A. Maximova, N. A. Zefirov, N. A. Lozinskaya, Birgit Wobith, Marina V. Proskurnina, Elena V. Kharitonashvili, Daniil R. Bazanov, Olga N. Zefirova, S. E. Sosonyuk
Publikováno v:
Mendeleev Communications. 30:7-9
To overcome the metabolic instability of anticancer agent 2-methoxyestradiol, two its dichloroacetylated prodrugs and three new control compounds have been synthesized and evaluated in different in vitro assays with cancer cells A549 and MCF-7. Both
Synthesis and cytotoxicity of novel simplified eleutherobin analogues as potential antitumour agents
Autor:
Yulia A. Gracheva, Vladimir A. Palyulin, Marina N. Semenova, Dmitry I. Osolodkin, Victor V. Semenov, Marina V. Proskurnina, Anastasia V Tutushkina, Alexander A. Shtil, Nikolay S. Zefirov, Valeria A. Glazunova, S. E. Sosonyuk, Dmitry A. Khlevin, N. A. Lozinskaya, Anita Peshich
Publikováno v:
Organicbiomolecular chemistry. 17(10)
Mixed simplified structures containing the paclitaxel and eleutherobin pharmacophore moieties were analyzed using molecular docking techniques and synthesized based on adamantane and 8-oxabicyclo[3.2.1]octane scaffolds. The crucial role of substituen
Autor:
Nikolay S. Zefirov, M. Yu. Seliverstov, O. I. Afanas’ev, Marina V. Proskurnina, V. V. Temnov, S. E. Sosonyuk
Publikováno v:
Doklady Chemistry. 466:41-44
Open image in new window A method of preparative successive cycloaddition to synthetic equivalent of bis(dehydrobenzene) was found. Monoaddition products were isolated and characterized.
Autor:
S. R. Engel, S. E. Sosonyuk, Nikolay S. Zefirov, N. A. Lozinskaya, Yu. N. Firsova, Marina V. Proskurnina
Publikováno v:
Russian Chemical Bulletin. 64:76-82
The preparative procedure for the synthesis of N-(2,2,2-trichloro-1-hydroxyethyl)aldimines from the corresponding aldehyde, chloral, and ammonium acetate was developed. Preparative silylation and acylation of their hydroxy groups were acomplished for
Autor:
Nikolay S. Zefirov, O. A. Tsyplenkova, S. E. Sosonyuk, M. Yu. Seliverstov, O. I. Afanas´ev, Marina V. Proskurnina
Publikováno v:
Russian Chemical Bulletin. 64:1470-1472
Homocoupling of 4-bromo-1,2,3-triazoles upon treatment with stoichiometric amount of bis(pinacolato)diboron on a palladium catalyst gives 4,4´-bi-1,2,3-triazoles in up to 95% yields.
Publikováno v:
European Journal of Organic Chemistry. 2013:2381-2388
The first directed synthesis of seven-membered mono- and tris-phosphates is described. The key steps involve a DIBAL-H/DIBAL-Cl-mediated ring opening of 8-oxabicyclo[3.2.1]octenes in the presence of [Ni(acac)2] and stereoselective syn-dihydroxylation
Publikováno v:
Tetrahedron. 68:5785-5792
The synthesis of new polyhydroxylated 8-oxabicyclo[3.2.1]octanes and 2,7-dioxatricyclo[4.2.1.03,8]nonanes is described. These structures is an interesting synthetic blocks for potential bioactive molecules. The precursor, 3-chloro-8-oxabicyclo[3.2.1]
Publikováno v:
Review Journal of Chemistry. 2:74-104
The key role of imines in organic synthesis, for example in the synthesis of amine derivatives and nitrogen heterocycles, is well known. However, the instability of N-unsubstituted imines is often an obstacle to the selection of synthesis strategy. T