Výsledky vyhledávání - "S. E. Hallam"

A systematic review of local excision followed by adjuvant therapy in early rectal cancer: are pT1 tumours the limit?

Autor: S. E. Hallam, J. E. Cutting, D. E. Messenger, M. G. Thomas

Publikováno v: Colorectal Disease. 20:854-863

Aim Total mesorectal excision remains the cornerstone of treatment for rectal cancer. Significant morbidity means local excision may be more appropriate in selected patients. Adjuvant therapy reduces local recurrence and improves survival; however, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e926a0589ed2b4b23d51dd5f2de453e
https://doi.org/10.1111/codi.14340

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Clinical manifestations in a large hereditary hemorrhagic telangiectasia (HHT) type 2 kindred

Autor: J E, McDonald, F J, Miller, S E, Hallam, L, Nelson, D A, Marchuk, K J, Ward

Publikováno v: American journal of medical genetics. 93(4)

HHT type 2 (HHT 2) is a multi-system vascular dysplasia caused by a mutation in the ALK-1 gene, but the phenotype has not been well defined. We report on 51 members of an HHT 2 kindred with an ALK-1 gene mutation shown to be associated with the disor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::93c5917b24a6c271a9f977d62c146a28
https://pubmed.ncbi.nlm.nih.gov/10946360

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Implications of a novel cryptic splice site in the BRCA1 gene

Autor: J D, Hoffman, S E, Hallam, V L, Venne, E, Lyon, K, Ward

Publikováno v: American journal of medical genetics. 80(2)

This study was designed to determine the significance of a single intronic base change (IVS5-12 G--A) found in a family with a history of breast cancer. This change is predicted to form a cryptic splice site resulting in the addition of 11 nucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26910a37e6d25323d704c43ea97def21
https://pubmed.ncbi.nlm.nih.gov/9805131

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Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes

Autor: H. Motamedi, C. R. Hutchinson, D. A. Sugden, G. O. Humphreys, H. M. Kieser, C. McKillop, S. E. Hallam, David A. Hopwood, C. R. Bailey, M. Warren, M. J. Butler, Francisco Malpartida

Publikováno v: Nature. 325:818-821

Many important antibiotics such as tetracyclines, erythromycin, adriamycin, monensin, rifamycin and avermectins are polyketides. In their biosynthesis, multifunctional synthases1 catalyse iterated condensation of thio-esters derived from acetate, pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dec066d5fa54cc543ba4e3a9922ef44
https://doi.org/10.1038/325818a0

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Isolation and characterization of monoclonal antibody-resistant mutants of Newcastle disease virus

Autor: P. H. Russell, S. E. Hallam, A. C. R. Samson

Publikováno v: The Journal of general virology. 66

Neutralizing monoclonal antibodies incorporated into plaque assay overlay medium were used to select antibody-resistant (AbR) mutants of both the Herts (using antifusion protein monoclonal 481) and Beaudette C (using anti-haemagglutinin-neuraminidase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cfcc239d87d8b200ae27d9bf43b226
https://pubmed.ncbi.nlm.nih.gov/3838186

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