Zobrazeno 1 - 7 of 7 pro vyhledávání: '"S. E. Girardin"'
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A178 ELUCIDATING THE ROLE OF THE LEUCINE-RICH REPEAT KINASE 2 G2019S MUTATION IN CROHN’S DISEASE PATHOGENESIS USING A CITROBACTER RODENTIUM INFECTIOUS COLITIS MODEL
Autor: B Samman, J Yadav, G Bayer, E G Foerster, L Chen, J D B Rocha, S E Girardin, D J Philpott
Publikováno v: Journal of the Canadian Association of Gastroenterology. 6:23-23
Background Associations have been found linking certain LRRK2 kinase domain gain-of-function variants, such as G2019S, to the development of Crohn’s disease and Parkinson’s disease, yet their exact roles in pathogenesis remains elusive. LRRK2 is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::986256c2eae947b7d1b60413a082a6c7
https://doi.org/10.1093/jcag/gwac036.178
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2
Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation
Autor: Laura Ferrero-Miliani, S E Girardin, Ole Haagen Nielsen, Paal Skytt Andersen
Publikováno v: Clinical and Experimental Immunology. 147:227-235
SummaryInflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process − which under normal conditions is self-limiting − becomes continuous and chronic in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa66472795891111d7a65ec51e8565c
https://doi.org/10.1111/j.1365-2249.2006.03261.x
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6
NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype
Autor: M G, Netea, G, Ferwerda, D J, de Jong, S E, Girardin, B J, Kullberg, J W M, van der Meer
Publikováno v: The Netherlands journal of medicine. 63(8)
Mutations of the NOD2 gene increase the susceptibility of humans to Crohn's disease. NOD2 is a cytoplasmic receptor for the bacterial product peptidoglycan. There is considerable controversy in the literature whether the most common mutation in Crohn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29d327b0d4a7e0215d5b4962477311a6
https://pubmed.ncbi.nlm.nih.gov/16186636
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Plný text Recenzováno Digitální knihovna AV ČR
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