Výsledky vyhledávání - "S. E. Barker"

Autor: Robin R. Ali, Colin J Chu, S E Barker, Andrew D. Dick

Publikováno v: Ocular Immunology and Inflammation. 20:394-405

Noninfectious intraocular inflammatory disease remains a significant cause of visual loss, even with current systemic immunosuppression. Alternative novel treatments are thus required, particularly for severe forms of posterior uveitis. Encouraging r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c865c167468f059685e8a7b3fe57229
https://doi.org/10.3109/09273948.2012.726392

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Long-Term Survival of Photoreceptors Transplanted into the Adult Murine Neural Retina Requires Immune Modulation

Autor: Ulrich F O Luhmann, Rachael A. Pearson, Emma L. West, Robin R. Ali, Alexander J. Smith, S. E. Barker, Amanda C. Barber, Yanai Duran, Robert E MacLaren, Jane C. Sowden

Publikováno v: Stem Cells. 28:1997-2007

Stem cell therapy presents an opportunity to replace photoreceptors that are lost as a result of inherited and age-related degenerative disease. We have previously shown that murine postmitotic rod photoreceptor precursor cells, identified by express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968acde09eb5fb6ffaf6fa30488e6a54
https://doi.org/10.1002/stem.520

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Gene therapy in the second eye of RPE65-deficient dogs improves retinal function

Autor: Paul G. Curran, Robin R. Ali, S. E. Barker, Matthew J. Annear, Alexander J. Smith, James W B Bainbridge, Simon M. Petersen-Jones, Joshua T. Bartoe

Publikováno v: Gene Therapy. 18:53-61

The purpose of this study was to evaluate whether immune responses interfered with gene therapy rescue using subretinally delivered recombinant adeno-associated viral vector serotype 2 carrying the RPE65 cDNA gene driven by the human RPE65 promoter (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034e96e91744ab11b93fdcfedf547251
https://doi.org/10.1038/gt.2010.111

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Lentiviral-vector-mediated expression of murine IL-1 receptor antagonist or IL-10 reduces the severity of endotoxin-induced uveitis

Autor: Scott J Robbie, Andrew D. Dick, Cathryn A Broderick, P. Trittibach, Yanai Duran, Alexander J. Smith, G.–M. Sarra, M. Natkunarajah, S. E. Barker, Robin R. Ali, James W B Bainbridge

Publikováno v: Gene Therapy. 15:1478-1488

Uveitis is a sight threatening inflammatory disorder that remains a significant cause of visual loss. We investigated lentiviral gene delivery of interleukin 1 receptor antagonist (IL-1ra) or interleukin (IL)-10 to ameliorate murine endotoxin-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27d5275ebb87d05ebd879488795b8cf
https://doi.org/10.1038/gt.2008.109

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Synthesis of Bifunctional Integrin-Binding Peptides Containing PEG Spacers of Defined Length for Non-Viral Gene Delivery

Autor: Supti Sarkar, Stephen L. Hart, Michael A. Pilkington-Miksa, S. E. Barker, Helen C. Hailes, Michele J. Writer, Alethea B. Tabor, Parviz Ayazi Shamlou

Publikováno v: European Journal of Organic Chemistry. 2008:2900-2914

Improving the buffer and serum stability of non-viral gene delivery vectors, and increasing their circulation time in vivo, is an important focus of current research in gene therapy. The most successful strategies to date have involved shielding the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b2be646916ab03492185a1a1e8012ca
https://doi.org/10.1002/ejoc.200701188

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Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12

Autor: S E Barker, Adrian J. Thrasher, E K Siapati, Stephen L. Hart, Christine Kinnon, A Kritz, S M Grosse

Publikováno v: British Journal of Cancer

Cytokine-modified tumour cells have been used in clinical trials for immunotherapy of neuroblastoma, but primary tumour cells from surgical biopsies are difficult to culture. Autologous fibroblasts, however, are straightforward to manipulate in cultu

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https://doi.org/10.1038/sj.bjc.6603857

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EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV

Autor: O. Kan, S. Iqball, Robert E MacLaren, Robin R. Ali, Kamaljit S. Balaggan, S. E. Barker, Margaret Esapa, Rachael A. Pearson, James W B Bainbridge, Katie Binley, Yanai Duran, Stuart Naylor, Andrew Smith

Publikováno v: Gene Therapy. 13:1153-1165

We evaluated the efficacy of equine infectious anaemia virus (EIAV)-based lentiviral vectors encoding endostatin (EIAV.endostatin) or angiostatin (EIAV.angiostatin) in inhibiting angiogenesis and vascular hyperpermeability in the laser-induced model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b654ccbfa325d4fa6732b1cdfdefdb
https://doi.org/10.1038/sj.gt.3302769

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Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12

Autor: Stephen L. Hart, Adrian J. Thrasher, R Anderson, A Michalski, S E Barker, Christine Kinnon, K E Siapati, Paul M. Brickell

Publikováno v: British Journal of Cancer

Neuroblastoma immunotherapy using cytokine-modified tumour cells has been tested in clinical trials. However, because of the complex nature of antitumour immune responses, a number of therapies may be required for complete tumour eradication and gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785a1905c8c692f87a62c197ba9b3370
http://europepmc.org/articles/PMC2377114

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