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Akademický článek

Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis

Autor: Sienna S. Drake, Aliyah Zaman, Christine Gianfelice, Elizabeth M.-L. Hua, Kali Heale, Elia Afanasiev, Wendy Klement, Jo Anne Stratton, Alexandre Prat, Stephanie Zandee, Alyson E. Fournier

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)

Abstract Background The role of senescence in disease contexts is complex, however there is considerable evidence that depletion of senescent cells improves outcomes in a variety of contexts particularly related to aging, cognition, and neurodegenera

Externí odkaz: https://doaj.org/article/07e09c6af8784c0bbef1de4e6dc3cbe6

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Akademický článek

Follicle-intrinsic and spatially distinct molecular programs drive follicle rupture and luteinization during ex vivo mammalian ovulation

Autor: Emily J. Zaniker, Jiyang Zhang, Daniela Russo, Ruixu Huang, Kristine Suritis, Riley S. Drake, Esther Barlow-Smith, Alex K. Shalek, Teresa K. Woodruff, Shuo Xiao, Brittany A. Goods, Francesca E. Duncan

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-23 (2024)

Abstract During ovulation, the apical wall of the preovulatory follicle breaks down to facilitate gamete release. In parallel, the residual follicle wall differentiates into a progesterone-producing corpus luteum. Disruption of ovulation, whether thr

Externí odkaz: https://doaj.org/article/422a5bda6fd7443eb783b07c2b18ee4b

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Akademický článek

An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection

Publikováno v: Microbiology Spectrum, Vol 12, Iss 6 (2024)

ABSTRACT Recent case reports and epidemiological data suggest that fungal infections represent an underappreciated complication among people with severe COVID-19. However, the frequency of fungal colonization in patients with COVID-19 and association

Externí odkaz: https://doaj.org/article/a7e7a9fbe87a46db9ef1b7216c890566

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Akademický článek

Metabolic responses of thermophilic endospores to sudden heat-induced perturbation in marine sediment samples

Autor: Anirban Chakraborty, Jayne E. Rattray, Sienna S. Drake, Stuart Matthews, Carmen Li, Bo Barker Jørgensen, Casey R. J. Hubert

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

Microbially mediated processes in a given habitat tend to be catalyzed by abundant populations that are ecologically adapted to exploit specific environmental characteristics. Typically, metabolic activities of rare populations are limited but may be

Externí odkaz: https://doaj.org/article/2e93112842b64dd5bb725bfd040ba9a2

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Akademický článek

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

Autor: Brittany A. Goods, Michael H. Askenase, Erica Markarian, Hannah E. Beatty, Riley S. Drake, Ira Fleming, Jonathan H. DeLong, Naomi H. Philip, Charles C. Matouk, Issam A. Awad, Mario Zuccarello, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing, the ICHseq Investigators

Publikováno v: JCI Insight, Vol 6, Iss 6 (2021)

Intracerebral hemorrhage (ICH) is a devastating form of stroke with a high mortality rate and few treatment options. Discovery of therapeutic interventions has been slow given the challenges associated with studying acute injury in the human brain. I

Externí odkaz: https://doaj.org/article/dccc1efbb5cf49e6a38ba45f13efaa23

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Akademický článek

Linking single-cell measurements of mass, growth rate, and gene expression

Autor: Robert J. Kimmerling, Sanjay M. Prakadan, Alejandro J. Gupta, Nicholas L. Calistri, Mark M. Stevens, Selim Olcum, Nathan Cermak, Riley S. Drake, Kristine Pelton, Frederik De Smet, Keith L. Ligon, Alex K. Shalek, Scott R. Manalis

Publikováno v: Genome Biology, Vol 19, Iss 1, Pp 1-13 (2018)

Abstract Mass and growth rate are highly integrative measures of cell physiology not discernable via genomic measurements. Here, we introduce a microfluidic platform enabling direct measurement of single-cell mass and growth rate upstream of highly m

Externí odkaz: https://doaj.org/article/e86b5438fb3e4a98ad23b6bf3b2b5f02

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Methods of the 7 th National Audit Project ( NAP7 ) of the Royal College of Anaesthetists: peri‐operative cardiac arrest

Publikováno v: Kane, A D, Armstrong, R A, Kursumovic, E, Cook, T M, Oglesby, F C, Moppett, I K, Moonesinghe, S R, Bouch, D C, Cordingley, J, Dorey, J, Finney, S J, Kunst, G, Nickols, G, Mouton, R, Nolan, J P, Pappachan, V J, Plaat, F, Samuel, K, Scholefield, B R, Varney, L, Vindrola-Padros, C, Wain, E C, Kendall, S W, Lourtie, J & Soar, J 2022, ' Methods of the 7th National Audit Project (NAP7) of the Royal College of Anaesthetists : peri-operative cardiac arrest ', Anaesthesia, vol. 77, no. 12, pp. 1376-1385 . https://doi.org/10.1111/anae.15856

Cardiac arrest in the peri-operative period is rare but associated with significant morbidity and mortality. Current reporting systems do not capture many such events, so there is an incomplete understanding of incidence and outcomes. As peri-operati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c06567a575506dce2ea4ae6588a84d
https://doi.org/10.1111/anae.15856

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