Zobrazeno 1 - 10
of 71
pro vyhledávání: '"S. Dittman"'
Autor:
Helene Jahn, Ladislav Bartoš, Grace I. Dearden, Jeremy S. Dittman, Joost C. M. Holthuis, Robert Vácha, Anant K. Menon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mitochondria are double-membrane-bounded organelles that depend critically on phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer membrane to support mitochondrial function, but how they do this is unclear.
Externí odkaz:
https://doaj.org/article/80090a11e13246b496e3a818de0be8af
Autor:
Yining Jiang, Batiste Thienpont, Vinay Sapuru, Richard K. Hite, Jeremy S. Dittman, James N. Sturgis, Simon Scheuring
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
High-Speed Atomic Force Microscopy movies of membrane proteins — diffusing and interacting in bilayers of controlled thickness — allow the determination of membrane-mediated membrane protein interaction energetics.
Externí odkaz:
https://doaj.org/article/d822ed8623bd4dad8e0d6482980b0861
Autor:
Fang Jiao, François Dehez, Tao Ni, Xiulian Yu, Jeremy S. Dittman, Robert Gilbert, Christophe Chipot, Simon Scheuring
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Direct visualization of the structural transformation from pre-pore to pore of the mammalian immune defense complex perforin-2 (PFN2) reveals a clockwise hand-over-hand mechanism that propagates at ~15 subunits per second.
Externí odkaz:
https://doaj.org/article/c56b9dd5af004db7bd0ceb5b19a5137d
Autor:
Joon Lee, Hermany Munguba, Vanessa A. Gutzeit, Deo R. Singh, Melanie Kristt, Jeremy S. Dittman, Joshua Levitz
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107891- (2020)
Externí odkaz:
https://doaj.org/article/44ebe951577447279a851d8c0b39ba3d
Autor:
Noah Guy Lewis Guiberson, André Pineda, Debra Abramov, Parinati Kharel, Kathryn E. Carnazza, Rachel T. Wragg, Jeremy S. Dittman, Jacqueline Burré
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Munc18-1 is an evolutionary conserved gene whose mutations are linked to various neurological diseases in human. In order to better understand the exact nature of the mutations, the authors here utilize several model systems to show mutant Munc18-1 c
Externí odkaz:
https://doaj.org/article/46814a5c07da4b2497e97fb3a489c145
Autor:
Birgit Ploier, Lydia N. Caro, Takefumi Morizumi, Kalpana Pandey, Jillian N. Pearring, Michael A. Goren, Silvia C. Finnemann, Johannes Graumann, Vadim Y. Arshavsky, Jeremy S. Dittman, Oliver P. Ernst, Anant K. Menon
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Retinitis pigmentosa is often caused by mutations that affect the activity or transport of rhodopsin, but some mutations cause disease even though an apparently functional protein is produced. Here the authors show that three such enigmatic mutants r
Externí odkaz:
https://doaj.org/article/94c82e6657484b44baee46822dc7c91b
Autor:
Evan Quon, Yves Y Sere, Neha Chauhan, Jesper Johansen, David P Sullivan, Jeremy S Dittman, William J Rice, Robin B Chan, Gilbert Di Paolo, Christopher T Beh, Anant K Menon
Publikováno v:
PLoS Biology, Vol 16, Iss 5, p e2003864 (2018)
Tether proteins attach the endoplasmic reticulum (ER) to other cellular membranes, thereby creating contact sites that are proposed to form platforms for regulating lipid homeostasis and facilitating non-vesicular lipid exchange. Sterols are synthesi
Externí odkaz:
https://doaj.org/article/efa2ddef75a04ab9ab955fc705402e73
Autor:
Guoqing, Xiang, Amanda, Acosta-Ruiz, Arthur, Radoux-Mergault, Melanie, Kristt, Jihye, Kim, Jared D, Moon, Johannes, Broichhagen, Asuka, Inoue, Francis S, Lee, Miriam, Stoeber, Jeremy S, Dittman, Joshua, Levitz
Publikováno v:
Science advances. 8(47)
Numerous processes contribute to the regulation of G protein-coupled receptors (GPCRs), but relatively little is known about rapid mechanisms that control signaling on the seconds time scale or regulate cross-talk between receptors. Here, we reveal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2523583945a57b8ee79f3e92cc09f573
https://pubmed.ncbi.nlm.nih.gov/36427324
https://pubmed.ncbi.nlm.nih.gov/36427324
Autor:
Guoqing Xiang, Amanda Acosta-Ruiz, Arthur Radoux-Mergault, Melanie Kristt, Jihye Kim, Jared D. Moon, Johannes Broichhagen, Asuka Inoue, Francis S. Lee, Miriam Stoeber, Jeremy S. Dittman, Joshua Levitz
Publikováno v:
Science Advances. 8
Numerous processes contribute to the regulation of G protein–coupled receptors (GPCRs), but relatively little is known about rapid mechanisms that control signaling on the seconds time scale or regulate cross-talk between receptors. Here, we reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f480549ce02e677c19e8c3c5498883c
https://doi.org/10.1126/sciadv.abq3363
https://doi.org/10.1126/sciadv.abq3363
Autor:
David Snead, Alex L. Lai, Rachel T. Wragg, Daniel A. Parisotto, Trudy F. Ramlall, Jeremy S. Dittman, Jack H. Freed, David Eliezer
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Complexin is a small soluble presynaptic protein that interacts with neuronal SNARE proteins in order to regulate synaptic vesicle exocytosis. While the SNARE-binding central helix of complexin is required for both the inhibition of spontaneous fusio
Externí odkaz:
https://doaj.org/article/87ddc4fc6fcc4acc82fe50487948e671