Zobrazeno 1 - 10
of 44
pro vyhledávání: '"S. Direito"'
Publikováno v:
Antimicrob Agents Chemother
Ojkic, N, Lilja, E, Oliveira Lebre Direito, S, Dawson, A, Allen, R J & Waclaw, B 2020, ' A roadblock-and-kill mechanism of action model for the DNA-targeting antibiotic ciprofloxacin ', Antimicrobial Agents and Chemotherapy, vol. 64, no. 9, e02487-19, pp. 1-17 . https://doi.org/10.1128/AAC.02487-19
Ojkic, N, Lilja, E, Oliveira Lebre Direito, S, Dawson, A, Allen, R J & Waclaw, B 2020, ' A roadblock-and-kill mechanism of action model for the DNA-targeting antibiotic ciprofloxacin ', Antimicrobial Agents and Chemotherapy, vol. 64, no. 9, e02487-19, pp. 1-17 . https://doi.org/10.1128/AAC.02487-19
Fluoroquinolones, antibiotics that cause DNA damage by inhibiting DNA topoisomerases, are clinically important, but their mechanism of action is not yet fully understood. In particular, the dynamical response of bacterial cells to fluoroquinolone exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e5a8872abc57eabbcedf0bee272d87
https://doi.org/10.1128/aac.02487-19
https://doi.org/10.1128/aac.02487-19
Autor:
Daniel J. M. Hodgson, Aidan T. Brown, Alex Lips, Job H. J. Thijssen, Cait E. MacPhee, John R. Royer, Andreia Silva, Lucas Le Nagard, Davide Marenduzzo, Wilson C. K. Poon, Simon Titmuss, S. Direito
Publikováno v:
Soft Matter
Poon, W C K, Brown, A T, Direito, S O L, Hodgson, D J M, Nagard, L L, Lips, A, MacPhee, C E, Marenduzzo, D, Royer, J R, Silva, A F, Thijssen, J H J & Titmuss, S 2020, ' Soft matter science and the COVID-19 pandemic ', Soft Matter . https://doi.org/10.1039/D0SM01223H
Poon, W C K, Brown, A T, Direito, S O L, Hodgson, D J M, Nagard, L L, Lips, A, MacPhee, C E, Marenduzzo, D, Royer, J R, Silva, A F, Thijssen, J H J & Titmuss, S 2020, ' Soft matter science and the COVID-19 pandemic ', Soft Matter . https://doi.org/10.1039/D0SM01223H
Much of the science underpinning the global response to the COVID-19 pandemic lies in the soft matter domain. Coronaviruses are composite particles with a core of nucleic acids complexed to proteins surrounded by a protein-studded lipid bilayer shell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69183673098227553729ca38f437c44c
http://arxiv.org/abs/2007.02127
http://arxiv.org/abs/2007.02127
Publikováno v:
eLife
Das, S G, Direito, S O L, Waclaw, B, Allen, R J & Krug, J 2020, ' Predictable Properties of Fitness Landscapes Induced by Adaptational Tradeoffs ', eLIFE, vol. 9, e55155, pp. 1-24 . https://doi.org/10.7554/eLife.55155
eLife, Vol 9 (2020)
Das, S G, Direito, S O L, Waclaw, B, Allen, R J & Krug, J 2020, ' Predictable Properties of Fitness Landscapes Induced by Adaptational Tradeoffs ', eLIFE, vol. 9, e55155, pp. 1-24 . https://doi.org/10.7554/eLife.55155
eLife, Vol 9 (2020)
Fitness effects of mutations depend on environmental parameters. For example, mutations that increase fitness of bacteria at high antibiotic concentration often decrease fitness in the absence of antibiotic, exemplifying a tradeoff between adaptation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783cdae7e2b60e508db9ee2da2e150ca
https://pubmed.ncbi.nlm.nih.gov/32423531
https://pubmed.ncbi.nlm.nih.gov/32423531
Publikováno v:
bioRxiv
Fluoroquinolones - antibiotics that cause DNA damage by inhibiting DNA topoisomerases - are clinically important, but their mechanism of action is not yet fully understood. In particular, the dynamical response of bacterial cells to fluoroquinolone e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a8bfb6158b1d72ccebcac060ad162c
https://doi.org/10.1101/791145
https://doi.org/10.1101/791145
Autor:
Patrick Harkness, David C. Cullen, Jean-Luc Josset, Samuel J. Payler, Claire R. Cousins, M. Downs, Graeme M. Hansford, David Lees, Matthew Gunn, Amber Gray, Jac Genis, Thomas W. D. Edwards, Xuan Li, S. Direito, Emma Meehan, Rachel Elizabeth Cross, Andrew J. Coates, David Mcluckie, Sean M. Paling, Audrey Souchon, John W. Holt, Jennifer F. Biddle, Melissa McHugh, Charles S. Cockell, Louise Yeoman, Darlene S. S. Lim
The authors would also like to acknowledge the funding provided by the STFC Impact Acceleration Fund. Claire R. Cousins is supported by a Royal Society of Edinburgh Research Fellowship. The development of the ExoMars PanCam, the AUPE2 system and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a34d1e2468407d9afee87501e86b818
https://eprints.gla.ac.uk/122750/13/122750.pdf
https://eprints.gla.ac.uk/122750/13/122750.pdf
Publikováno v:
Environmental Microbiology. 16:643-657
Whole genome amplification methods facilitate the detection and characterization of microbial communities in low biomass environments. We examined the extent to which the actual community structure is reliably revealed and factors contributing to bia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::376e17094bf445d5fe6aef0a9579bb24
https://doi.org/10.1111/1462-2920.12365
https://doi.org/10.1111/1462-2920.12365
Autor:
Jesse P. Harrison, Lena Noack, S. Direito, Andrew Rushby, Helmut Lammer, Petra Schwendner, Javier Martin-Torres, Jennifer Wadsworth, Hanna Landenmark, Charles S. Cockell, Samuel J. Payler, Casey Bryce, Mark Fox-Powell, María Paz Zorzano, Jack T. O'Malley-James, Toby Samuels, T. Bush, Natasha Nicholson
Publikováno v:
Astrobiology. 16(1)
Habitability is a widely used word in the geoscience, planetary science, and astrobiology literature, but what does it mean? In this review on habitability, we define it as the ability of an environment to support the activity of at least one known o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7bdf988c7220807b7cc74f3db0237d
https://pubmed.ncbi.nlm.nih.gov/26741054
https://pubmed.ncbi.nlm.nih.gov/26741054
Publikováno v:
FEMS Microbiology Ecology. Oxford University Press
FEMS Microbiology Ecology, 81, 111-123. Oxford University Press
Direito, S O L, Marees, A & Roling, W F M 2012, ' Sensitvie life detection strategies for low-biomass environments: optimizing extraction of nucleic acids adsorbing to terrestrial and Mars analogue minerals. ', FEMS Microbiology Ecology, vol. 81, pp. 111-123 . https://doi.org/10.1111/j.1574-6941.2012.01325.x
FEMS Microbiology Ecology, 81, 111-123. Oxford University Press
Direito, S O L, Marees, A & Roling, W F M 2012, ' Sensitvie life detection strategies for low-biomass environments: optimizing extraction of nucleic acids adsorbing to terrestrial and Mars analogue minerals. ', FEMS Microbiology Ecology, vol. 81, pp. 111-123 . https://doi.org/10.1111/j.1574-6941.2012.01325.x
The adsorption of nucleic acids to mineral matrixes can result in low extraction yields and negatively influences molecular microbial ecology studies, in particular for low-biomass environments on Earth and Mars. We determined the recovery of nucleic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79babb62a7e2309c8acf37297b5def6b
https://doi.org/10.1111/j.1574-6941.2012.01325.x
https://doi.org/10.1111/j.1574-6941.2012.01325.x
Autor:
Andries T. Marees, Wilfred F. M. Röling, Pascale Ehrenfreund, Martijn Staats, S. Direito, B.H. Foing
Publikováno v:
Direito, S, Ehrenfreund, P, Marees, A, Foing, B H & Röling, W F M 2011, ' A wide variety of putative extremophiles and large beta-diversity at the Mars Desert Research Station (Utah) ', International Journal of Astrobiology . https://doi.org/10.1017/S1473550411000012
International Journal of Astrobiology. Cambridge University Press
International Journal of Astrobiology, 10(10):3, 191-207. Cambridge University Press
Oliveira Lebre Direito, M S, Ehrenfreund, P, Marees, A, Staats, M & Roling, W F M 2011, ' A wide variety of putative extremophiles and large beta-diversity at the Mars Desert Research Station. ', International Journal of Astrobiology, vol. 10, no. 10, 3, pp. 191-207 . https://doi.org/10.1017/S1473550411000012
International Journal of Astrobiology. Cambridge University Press
International Journal of Astrobiology, 10(10):3, 191-207. Cambridge University Press
Oliveira Lebre Direito, M S, Ehrenfreund, P, Marees, A, Staats, M & Roling, W F M 2011, ' A wide variety of putative extremophiles and large beta-diversity at the Mars Desert Research Station. ', International Journal of Astrobiology, vol. 10, no. 10, 3, pp. 191-207 . https://doi.org/10.1017/S1473550411000012
Humankind's innate curiosity makes us wonder whether life is or was present on other planetary bodies such as Mars. The EuroGeoMars 2009 campaign was organized at the Mars Desert Research Station (MDRS) to perform multidisciplinary astrobiology resea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0b09265f2077362391e93500588bab
https://hdl.handle.net/1871/36455
https://hdl.handle.net/1871/36455