Zobrazeno 1 - 10
of 243
pro vyhledávání: '"S. De Lombaert"'
Autor:
Jinhui Wang1, Shengchun Wang2, Zhihong Wei3, Pengjie Wang2, Yanwei Cao1, Yang Huang1, Lin He1, Aiwen Lei2 helin@licp.cas.cn
Publikováno v:
Science. 11/15/2024, Vol. 386 Issue 6723, p776-782. 7p. 5 Diagrams.
Non-Peptidic CRF1 Receptor Antagonists for the Treatment of Anxiety, Depression and Stress Disorders
Autor:
S De Lombaert, John H. Kehne
Publikováno v:
Current Drug Target -CNS & Neurological Disorders. 1:467-493
Anxiety and depression are psychiatric disorders that constitute a major health concern worldwide, and new pharmacological approaches with the potential for improved efficacy and decreased side effect profiles relative to currently marketed drugs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f13bfd86c9710759f7920cc02f0c13
https://doi.org/10.2174/1568007023339049
https://doi.org/10.2174/1568007023339049
Autor:
Paula Savage, Angelo J. Trapani, Arco Y. Jeng, Charles W. Bruseo, Mary Chou, S. De Lombaert, Michael E. Beil
Publikováno v:
Life Sciences. 67:1025-1033
Endothelin-1 (ET- 1) is a potent vasoconstrictor. Its biosynthesis is catalyzed by endothelin converting enzyme (ECE). In contrast, atrial natriuretic peptide (ANP) is a potent vasorelaxant and diuretic, and it is mainly degraded by neutral endopepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51113b47714f51d3ea8bec2067e1e504
https://doi.org/10.1016/s0024-3205(00)00695-0
https://doi.org/10.1016/s0024-3205(00)00695-0
Autor:
John Moliterni, Arco Y. Jeng, John Fitt, Lisa B. Stamford, Eli M. Wallace, L. Blanchard, Mary Chou, S. De Lombaert, Jenny Tan, Paula Savage, Daniel Hoyer, N. Marcopoulos, D. Simonsbergen, Angelo J. Trapani, Yoshitaka Satoh
Publikováno v:
Journal of Medicinal Chemistry. 43:488-504
Potent and selective non-peptidic inhibitors of human endothelin-converting enzyme-1 (ECE-1) have been designed as potential modulators of endothelin (ET-1) production in vivo. Because of its unique structural characteristics and long duration of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da0798a1513794fd943fbf212c2c338
https://doi.org/10.1021/jm990507o
https://doi.org/10.1021/jm990507o
Autor:
Mark D. Erion, L. Blanchard, Angelo J. Trapani, L. El‐Chehabi, Jenny Tan, Carol Berry, R. D. Ghai, S. De Lombaert, Yumi Sakane
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c35dca5d84734229c1a74636f11f05d
https://doi.org/10.1002/chin.199425207
https://doi.org/10.1002/chin.199425207
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0438c4e1f9c67ebc072fbc2d9d5e82b5
https://doi.org/10.1002/chin.199524173
https://doi.org/10.1002/chin.199524173
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f70c98f55de48369b9f9d3cc211125
https://doi.org/10.1002/chin.199524172
https://doi.org/10.1002/chin.199524172
Autor:
S. De Lombaert, Arco Y. Jeng
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e66e46dc31824dd145ffc673585206e
https://doi.org/10.1002/chin.199811312
https://doi.org/10.1002/chin.199811312
Autor:
Michael A. Moskal, S. De Lombaert, Yoshitaka Satoh, John Moliterni, Jenny Tan, Nicholas Marcopulos, Eli M. Wallace
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ffd1d31ef32cbbb00e41c90c9cc0342
https://doi.org/10.1002/chin.199831131
https://doi.org/10.1002/chin.199831131
Publikováno v:
Journal of Cardiovascular Pharmacology. 31:S68-S70
Optimization of an aminophosphonic acid series of compounds for inhibition of endothelin-converting enzyme (ECE) has led to the discovery of CGS 31447. This compound reversibly inhibited the activity of recombinant human ECE-1 with an IC50 value of 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b159e76078568d7329022002c7f2ec5a
https://doi.org/10.1097/00005344-199800001-00022
https://doi.org/10.1097/00005344-199800001-00022