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Evolutionary diversification of insulin-related peptides (IRPs) in aphids and spatiotemporal distribution in Acyrthosiphon pisum

Autor: Karen Gaget, M. Ribeiro Lopes, S. De Groef, Federica Calevro, Patrick Callaerts, Sergio Peignier, C. Huygens, Gabrielle Duport, Nicolas Parisot

Publikováno v: Insect Biochemistry and Molecular Biology
Insect Biochemistry and Molecular Biology, Elsevier, In press, pp.103670. ⟨10.1016/j.ibmb.2021.103670⟩

International audience; Les membres de la superfamille de l'insuline activent la voie de signalisation évolutive hautement conservée de l'insuline/du facteur de croissance analogue à l'insuline, impliquée dans la régulation de la croissance, de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63dcba896506b88de64e6ef3ae47b24f
https://pubmed.ncbi.nlm.nih.gov/34666188

Accessory cells for beta cell transplantation

Autor: N. De Leu, Yves Heremans, Violette Coppens, M. Van de Casteele, S. De Groef, Aernout Luttun, Gunter Leuckx, Harry Heimberg, I. Van Riet, N. Van Gassen, Willem Staels

Publikováno v: Diabetes obesity and metabolism

Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycemic alterations and life-threatening complications. Restoration of the endogenous beta cell mass through regeneration or tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7912404ecf9553cb4f12b862e97203
https://hdl.handle.net/20.500.14017/718adff5-2c90-4e63-83da-7dd45bca605d

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Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas

Autor: S. De Groef, Ulf Ahlgren, Ari Waisman, Gunter Leuckx, C. Svensson, Ole D. Madsen, Violette Coppens, Yuval Dor, Harry Heimberg, M. Van de Casteele, Jonas Ahnfelt-Rønne, Luc Baeyens, Yixing Yuchi, Jan N. Jensen, Maria Eriksson, Ying Cai

Publikováno v: Cell Death & Disease
Cell Death and Disease

We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to beta cells ex vivo. Here we evaluate the role of Ngn3(+) cells in beta cell expansion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306f19ee43c6ded3c356b9727f49ae53
http://europepmc.org/articles/PMC3613830