Synthesis and Radiosynthesis of Prospective 2-Nitroimidazole Hypoxia­ PET Tracers via Thiazolidine Ligation with 5-Fluorodeoxyribose (FDR)

Autor: M. Musolino, S. Dall’Angelo, M. Zanda

Publikováno v: SynOpen, Vol 01, Iss 01, Pp 0173-0179 (2017)

Abstract The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation. The

Externí odkaz: https://doaj.org/article/4582cb51f6724c1c966088828acd5978

Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by H-1 NMR spectroscopy

Autor: Diaz-Rullo, FF (Diaz-Rullo, Fernando Fernandez)[ 1,2 ], Zamberlan, F (Zamberlan, Francesco)[ 1,2 ], Mewis, RE (Mewis, Ryan E.)[ 3 ], Fekete, M (Fekete, Marianna)[ 3 ], Broche, L (Broche, Lionel)[ 1,2 ], Cheyne, LA (Cheyne, Lesley A.)[ 1,2 ], Dall'Angelo, S (Dall'Angelo, Sergio)[ 1,2 ], Duckett, SB (Duckett, Simon B.)[ 3 ], Dawson, D (Dawson, Dana)[ 1,2 ], Zanda, M (Zanda, Matteo)[ 1,2,4 ]

Publikováno v: Bioorganic & medicinal chemistry
25 (2017): 2730–2742. doi:10.1016/j.bmc.2017.03.041
info:cnr-pdr/source/autori:Diaz-Rullo, FF (Diaz-Rullo, Fernando Fernandez)[ 1,2 ] ; Zamberlan, F (Zamberlan, Francesco)[ 1,2 ] ; Mewis, RE (Mewis, Ryan E.)[ 3 ] ; Fekete, M (Fekete, Marianna)[ 3 ] ; Broche, L (Broche, Lionel)[ 1,2 ] ; Cheyne, LA (Cheyne, Lesley A.)[ 1,2 ] ; Dall'Angelo, S (Dall'Angelo, Sergio)[ 1,2 ] ; Duckett, SB (Duckett, Simon B.)[ 3 ] ; Dawson, D (Dawson, Dana)[ 1,2 ] ; Zanda, M (Zanda, Matteo)[ 1,2,4 ]/titolo:Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by H-1 NMR spectroscopy/doi:10.1016%2Fj.bmc.2017.03.041/rivista:Bioorganic & medicinal chemistry (Print)/anno:2017/pagina_da:2730/pagina_a:2742/intervallo_pagine:2730–2742/volume:25

Hyperpolarization enhances the intensity of the NMR signals of a molecule, whose in vivo metabolic fate can be monitored by MRI with higher sensitivity. SABRE is a hyperpolarization technique that could potentially be used to image nitric oxide (NO)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::f89dee4064251e4742bdc167cc1d007f
https://publications.cnr.it/doc/373498

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