Výsledky vyhledávání - "S. DE BERNARDO"

Neurotrophic and neurotoxic effects of nitric oxide on fetal midbrain cultures

Autor: Maria Angeles Mena, E. Rodríguez‐Martín, María José Casarejos, Santiago Canals, S de Bernardo

Publikováno v: Journal of Neurochemistry. 76:56-68

There is evidence suggesting that nitric oxide (NO) may play an important role in dopamine (DA) cell death. Thus, the aim of this study was to investigate the effects of NO on apoptosis and functionality of DA neurones and glial cells. The experiment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6126ca498621be2ffdc9803e96fbfa3
https://doi.org/10.1046/j.1471-4159.2001.00010.x

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Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron/glia mesencephalic cultures

Autor: Maria Angeles Mena, Santiago Canals, Rosa M. Solano, J. Menéndez, María José Casarejos, S de Bernardo

Publikováno v: Journal of Neurochemistry

To date, glutathione (GSH) depletion is the earliest biochemical alteration shown in brains of Parkinson's disease patients, but the role of GSH in dopamine cell survival is debated. In this study we show that GSH depletion, produced with GSH synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28368d05937199864e5779b6d19e2c4c
https://doi.org/10.1111/j.1471-4159.2004.02744.x

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Glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways

Autor: María José Casarejos, E. Rodríguez‐Martín, S de Bernardo, Maria Angeles Mena, Santiago Canals

Publikováno v: Journal of Neuroscience Research. 73:818-830

The mesencephalic astroglia-conditioned medium (GCM) greatly increases dopamine (DA) phenotype expression, and it also protects from spontaneous and toxin-induced cell death in midbrain cultures. In this study, we have investigated the signaling path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3a9e51efe4bc8eea460c6634208dd6
https://doi.org/10.1002/jnr.10704

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Glutathione depletion switches nitric oxide neurotrophic effects to cell death in midbrain cultures: implications for Parkinson's disease

Autor: Maria Angeles Mena, S de Bernardo, E. Rodríguez‐Martín, María José Casarejos, Santiago Canals

Publikováno v: Journal of Neurochemistry. 79:1183-1195

Nitric oxide (NO) exerts neurotrophic and neurotoxic effects on dopamine (DA) function in primary midbrain cultures. We investigate herein the role of glutathione (GSH) homeostasis in the neurotrophic effects of NO. Fetal midbrain cultures were pretr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::765f2a8cf2d98096b5231a2ca9e37803
https://doi.org/10.1046/j.1471-4159.2001.00635.x

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l-DOPA and glia-conditioned medium have additive effects on tyrosine hydroxylase expression in human catecholamine-rich neuroblastoma NB69 cells

Autor: Maria Angeles Mena, S de Bernardo, María José Casarejos, Santiago Canals, A Handler, E. Rodríguez‐Martín

Publikováno v: Journal of Neurochemistry. 78:535-545

The aim of this study was to investigate the effect of L-DOPA and glia-conditioned medium (GCM) on cell viability, tyrosine hydroxylase (TH) expression, dopamine (DA) metabolism and glutathione (GSH) levels of NB69 cells. L-DOPA (200 microM) induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79a4c55b6c76b3c15c6eb96044a54e5b
https://doi.org/10.1046/j.1471-4159.2001.00440.x

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Thiolic antioxidants protect from nitric oxide-induced toxicity in fetal midbrain cultures

Autor: E. Rodríguez‐Martín, Maria Angeles Mena, S de Bernardo, Santiago Canals, María José Casarejos

Publikováno v: Neuropharmacology

Nitric oxide (NO) may act as a neuroprotector or neurotoxic agent in dopamine neurons, depending on cell redox status. We have investigated the effect of several thiolic antioxidants, glutathione (GSH), its cell permeable analog GSH ethyl ester (GSHE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf22365010e41b6c2f8bcb80a8dd372
https://pubmed.ncbi.nlm.nih.gov/12384173

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