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Chronic overexpression of membrane-bound flt3 ligand by T lymphocytes in severe aplastic anaemia

Autor: Otmar Pfister, Christoph Rahner, Catherine Nissen, Nina Hurwitz, S. D. Lyman, Wendy Jansen, Elena Chklovskaia, Kinga Mészáros, Aleksandra Wodnar-Filipowicz, Natalia Bogatcheva

Publikováno v: British Journal of Haematology. 109:211-220

Aplastic anaemia (AA) is an immune-mediated bone marrow failure associated with high serum levels of flt3 ligand (FL). We examined expression of the membrane-bound isoform of FL in peripheral blood and bone marrow cells from AA patients at diagnosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2100b93fb8e59fef9185204cad9320f
https://doi.org/10.1046/j.1365-2141.2000.02008.x

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Mechanism of flt3 Ligand Expression in Bone Marrow Failure: Translocation From Intracellular Stores to the Surface of T Lymphocytes After Chemotherapy-Induced Suppression of Hematopoiesis

Autor: E, Chklovskaia, W, Jansen, C, Nissen, S D, Lyman, C, Rahner, L, Landmann, A, Wodnar-Filipowicz

Publikováno v: Blood. 93:2595-2604

The flt3 ligand (FL) is a growth factor for primitive hematopoietic cells. Serum levels of FL are inversely related to the number and proliferative capacity of early hematopoietic progenitors. We sought to elucidate the molecular mechanism underlying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82b163d54a6ce36ad77b686bd47af43
https://doi.org/10.1182/blood.v93.8.2595.408k16_2595_2604

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FLT-3 Ligand Provides Hematopoietic Protection From Total Body Irradiation in Rabbits

Autor: André Tichelli, A. Gratwohl, Helen Baldomero, Nissen C, L. John, A. Wodnar-Filipowicz, S. D. Lyman, Roth J

Publikováno v: Blood. 92:765-769

Several hematopoietic cytokines have been investigated for their potential to provide protection from the lethal consequences of bone marrow aplasia after total body irradiation (TBI). Some can increase the dose of irradiation tolerated by the animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504c01eeec36afdfd31e48cd06d839cc
https://doi.org/10.1182/blood.v92.3.765

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Flt3 Ligand Enhances the Yield of Primitive Cells After Ex Vivo Cultivation of CD34+ CD38dim Cells and CD34+ CD38dim CD33dim HLA-DR+ Cells

Autor: S D Lyman, Barbara K. Oppenlander, Douglas C. Dooley, J M Plunkett, Mang Xiao

Publikováno v: Blood. 90:3903-3913

Flt3 ligand (FL) has been proposed as a possible modulator of early hematopoietic cell growth. The purpose of this study was to analyze the impact of FL on ex vivo expansion of hematopoietic cells obtained from adult donors. We sought to precisely id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ca49f77a90ef3cdf3f5966005112923
https://doi.org/10.1182/blood.v90.10.3903

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Flt3 ligand level reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia

Autor: Aleksandra Wodnar-Filipowicz, Alois Gratwohl, André Tichelli, Catherine Nissen, Bruno Speck, S. D. Lyman

Publikováno v: Blood. 88:4493-4499

Flt3 ligand (flt3L) is a member of a small family of cytokines acting as tyrosine kinase receptor ligands that stimulate the proliferation of primitive hematopoietic progenitors in vitro. To gain insight into the physiological role of flt3L in early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cafc0541e52932f58bbd2d2e392a7f
https://doi.org/10.1182/blood.v88.12.4493.bloodjournal88124493

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Influence of steel factor on hemoglobin synthesis in sickle cell disease

Autor: B A, Miller, S P, Perrine, A, Bernstein, S D, Lyman, D E, Williams, L L, Bell, N F, Olivieri

Publikováno v: Blood. 79:1861-1868

A new hematopoietic growth factor (Steel factor) has been identified which stimulates erythroid proliferation both in vitro and in vivo. We evaluated the influence of recombinant Steel factor on hemoglobin synthesis in peripheral blood (PB) BFU-E-der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd0810f3e291a61f76c0e161c1197f6
https://doi.org/10.1182/blood.v79.7.1861.bloodjournal7971861

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c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas

Autor: D E Williams, Y Mishima, S D Lyman, Yosef Yarden, T Boulton, Melanie H. Cobb, D M Anderson, B Fan, Y Funasaka, R Zakut

Publikováno v: Molecular Biology of the Cell. 3:197-209

The proto-oncogene c-Kit, a transmembrane receptor tyrosine kinase, is an important regulator of cell growth whose constitutively active oncogenic counterpart, v-kit, induces sarcomas in cats. Mutations in murine c-kit that reduce the receptor tyrosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871bdec384212b563e5281de12a6899f
https://doi.org/10.1091/mbc.3.2.197

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Chronic overexpression of membrane-bound flt3 ligand by T lymphocytes in severe aplastic anaemia

Autor: O, Pfister, E, Chklovskaia, W, Jansen, K, Mészáros, C, Nissen, C, Rahner, N, Hurwitz, N, Bogatcheva, S D, Lyman, A, Wodnar-Filipowicz

Publikováno v: British journal of haematology. 109(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81d104ad91267a0db0eb136ab79a2168
https://pubmed.ncbi.nlm.nih.gov/10848802

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Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells

Autor: H J, McKenna, K L, Stocking, R E, Miller, K, Brasel, T, De Smedt, E, Maraskovsky, C R, Maliszewski, D H, Lynch, J, Smith, B, Pulendran, E R, Roux, M, Teepe, S D, Lyman, J J, Peschon

Publikováno v: Blood. 95(11)

The ligand for the receptor tyrosine kinase fms-like tyrosine kinase 3 (flt3), also referred to as fetal liver kinase-2 (flk-2), has an important role in hematopoiesis. The flt3 ligand (flt3L) is a growth factor for hematopoietic progenitors and indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c437e0e4d22bb63e4af80a4e6362bb6
https://pubmed.ncbi.nlm.nih.gov/10828034

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Synergy of growth factors during mobilization of peripheral blood precursor cells with recombinant human Flt3-ligand and granulocyte colony-stimulating factor in rabbits

Autor: Miklos Pless, Aleksandra Wodnar-Filipowicz, Catherine Nissen, Alois Gratwohl, Linde John, S. D. Lyman, Helen Baldomero

Publikováno v: Experimental hematology. 27(1)

The potential of recombinant human (rh)Flt3 ligand (FL), alone or in combination with other recombinant growth factors, to mobilize peripheral blood precursor cells (PBPCs) was examined in an animal model. Adult outbred New Zealand White rabbits rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3adcf27f8ab32ffa4a78f5f3e8a1d37
https://pubmed.ncbi.nlm.nih.gov/9923454

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