Zobrazeno 1 - 10
of 28
pro vyhledávání: '"S. D. Kemp"'
Autor:
Kurt Hertogs, R Pauwels, S. D. Kemp, Schlomo Staszewski, Veronica Miller, Martin Stürmer, Jingshan Ren, B. A. Larder, David I. Stuart, David K. Stammers, R. L. Desmet, Stuart Bloor
Publikováno v:
Scopus-Elsevier
To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c8f4e46ae7c1f82b43696643b47260
https://ora.ox.ac.uk/objects/uuid:c02b6582-c197-4b96-8d40-3b9caf461d22
https://ora.ox.ac.uk/objects/uuid:c02b6582-c197-4b96-8d40-3b9caf461d22
Autor:
M. G. P. Cavitte, D. A. Young, R. Mulvaney, C. Ritz, J. S. Greenbaum, G. Ng, S. D. Kempf, E. Quartini, G. R. Muldoon, J. Paden, M. Frezzotti, J. L. Roberts, C. R. Tozer, D. M. Schroeder, D. D. Blankenship
Publikováno v:
Earth System Science Data, Vol 13, Pp 4759-4777 (2021)
We present an ice-penetrating radar data set which consists of 26 internal reflecting horizons (IRHs) that cover the entire Dome C area of the East Antarctic plateau, the most extensive to date in the region. This data set uses radar surveys collecte
Externí odkaz:
https://doaj.org/article/073c1c3576214e2e9ef28783588ce28f
Autor:
M. Van Houtte, C. van den Eynde, Timothy M. Alcorn, Veronica Miller, R Pauwels, Brendan Larder, Stuart Bloor, S. D. Kemp, Kurt Hertogs, S Staszewski
Publikováno v:
AIDS. 14:1203-1210
Objective: To evaluate in HIV-1 the extent of phenotypic and genotypic antiretroviral drug resistance and cross-resistance towards the protease inhibitors (Pls) saquinavir, ritonavir, indinavir and nelfinavir among a set of patient samples originatin
Autor:
P. Richard Harrigan, S. D. Kemp, Phillip Griffin, Chris Stone, Brendan Larder, Isabel Najera, Stuart Bloor, Margaret Tisdale
Publikováno v:
The Journal of Infectious Diseases. 181:912-920
Abacavir (1592U89) is a nucleoside inhibitor of human immunodeficiency virus (HIV) type 1 reverse transcriptase (RT). Resistance to abacavir was studied with abacavir alone and with abacavir in combination with other nucleoside analogues in cell cult
Autor:
Julio S. G. Montaner, Rudi Pauwels, Christopher S. Alexander, Werner Verbiest, P. R. Harrigan, Kurt Hertogs, Stuart Bloor, Benita Yip, S. D. Kemp, Brendan Larder, Robert S. Hogg
Publikováno v:
AIDS. 13:1863-1871
To determine whether baseline drug resistance assays could help to predict treatment failure with the protease inhibitor combination ritonavir-saquinavir.Baseline HIV-1 drug resistance was determined for 76 consecutive patients who started treatment
Autor:
Marie-Pierre de Béthune, P. Richard Harrigan, Schlomo Staszewski, Kurt Hertogs, Veronica Miller, Rudi Pauwels, Stuart Bloor, Carsten Rottmann, Brendan Larder, Andrew N. Phillips, S. D. Kemp
Publikováno v:
The Journal of Infectious Diseases. 177:1521-1532
Human immunodeficiency virus type 1 (HIV-1) strains dually resistant to zidovudine and lamivudine (3TC) may arise during zidovudine-3TC combination therapy. The objective of this cross-sectional study (n = 43 patients) was to test the association bet
Autor:
S D Kemp, Kevin N. Pennington, S Bloor, M H St Clair, B A Larder, Robert T. Schooley, A. Kohli, P R Harrigan, J M Lange
Publikováno v:
Journal of virology, 70(9), 5922-5929. American Society for Microbiology
Human immunodeficiency virus type 1 (HIV-1) isolates obtained prior to and during a combination therapy trial comparing zidovudine (AZT; 3'-azidothymidine) monotherapy with AZT plus 2',3'-dideoxyinosine (ddI) or AZT plus 2',3'-dideoxycytidine (ddC) w
Publikováno v:
Science. 269:696-699
Combinations of antiretroviral drugs that prevent or delay the appearance of drug-resistant human immunodeficiency virus-type 1 (HIV-1) mutants are urgently required. Mutants resistant to 3'-azidothymidine (AZT, zidovudine) became phenotypically sens
Publikováno v:
Proceedings of the National Academy of Sciences. 90:5653-5656
Resistant variants of human immunodeficiency virus type 1 (HIV-1) have been selected by limited passage in MT4 cells of both wild-type and 3'-azido-3'-deoxythymidine (AZT, zidovudine)-resistant strains with the nucleoside analogues (-)-2'-deoxy-3'-th
Autor:
E S Furfine, Katarzyna Bebenek, J E Reardon, S D Kemp, B A Larder, Kristin A. Eckert, Simon F. Lacey, Thomas A. Kunkel
Publikováno v:
Journal of Biological Chemistry. 267:15789-15794
A series of biochemical investigations to compare the DNA polymerase and RNase H functions of the reverse transcriptases (RTs) corresponding to azidothymidine (AZT)-sensitive and -resistant human immunodeficiency virus (HIV) strains are described. St