Zobrazeno 1 - 10
of 19
pro vyhledávání: '"S. D. Holladay"'
Publikováno v:
Journal of Immunotoxicology. 2:33-40
Season of birth correlates with approximately 10-fold increased risk of early mortality from infectious disease in parts of The Gambia, West Africa. The increased early death occurred in individuals aged 25-50, who were born during the nonharvest sea
Publikováno v:
Critical Reviews in Toxicology. 35:299-302
Autor:
S D Holladay, B L Blaylock
Publikováno v:
Human & Experimental Toxicology. 21:525-531
The laboratory mouse has been the most extensively used model system for demonstrating postnatal immune deficits following perinatal immunotoxicant exposure. Assays utilized have historically been those developed for adult mice. Clear gaps in the ava
Publikováno v:
Journal of Aquatic Animal Health. 11:183-186
Tricaine methanesulfonate (MS-222) is one of the most broadly used anesthetic and tranquilizing agents for poikilotherms, and it is currently the only anesthetic approved for use with food fish. To test the preliminary observation in tilapias Oreochr
Publikováno v:
Toxicology Methods. 9:57-70
The prospect of utilizing the cichlid teleost tilapia (Oreochromis niloticus) as an alternative experimental model to mammals for preliminary chemical immunotoxicity risk assessment is being evaluated by examining the National Toxicology Program's st
Autor:
Gary J. Rosenthal, Michael I. Luster, J.J. Heindel, George C. Clark, B L Blaylock, C E Comment, S. D. Holladay, Dori R. Germolec
Publikováno v:
Chemosphere. 25:115-118
Immunotoxicity is a common occurrence in experimental animals following exposure to TCDD. In addition to thymic atrophy, immunotoxicity is characterized by suppression of antibody responses in adult mice and suppression of cell-mediated immunity foll
Autor:
C E Comment, Dori R. Germolec, J. J. Heindell, P. Lindstrom, Michael I. Luster, B L Blaylock, S. D. Holladay
Publikováno v:
Teratology. 44:385-393
In utero exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was found to alter expression of murine thymocyte fetal cell-surface markers. Pregnant mice were treated (via gavage) with 0, 1.5, or 3.0 micrograms TCDD/kg
Publikováno v:
Teratology. 62(6)
Maternal immune stimulation has reported, but unconfirmed, efficacy for reducing chemical-induced morphologic defects in mice.Teratogenic chemicals (2,3,7, 8-tetrachlorodibenzo-p-dioxin [TCDD], ethyl carbamate [urethane], methylnitrosourea [MNU], or
Publikováno v:
Teratology. 62(6)
Maternal immune stimulation reduces malformations caused by chemical teratogens. Mechanisms for this effect are not known. Altered expression of regulatory molecules (e.g., transforming growth factor [TGF-beta], tumor necrosis factor-alpha [TNF-alpha
Publikováno v:
Cytometry. 39(4)
Chemical induction of apoptosis in cells is believed to contribute to toxicity. Techniques for measuring apoptosis have increased in both sensitivity and number and in many cases can be readily extended to nontraditional research species. A compariso