Zobrazeno 1 - 10
of 54
pro vyhledávání: '"S. D. Comis"'
Publikováno v:
Acta Oto-Laryngologica. 119:42-47
The various effects of ageing on the auditory system, collectively termed presbycusis, are being studied across a wide range of animal species, including humans. One contributing factor to presbycusis is thought to be losses of the sensory hair cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03874bf411859246a2a2f1c8f92217f0
https://doi.org/10.1080/00016489950181918
https://doi.org/10.1080/00016489950181918
Publikováno v:
Journal of Infection. 36:73-77
Acute changes in the electrophysiology and ultrastructure of the organ of Corti were studied after microperfusion of c. 5 x 10(6) CFU of serotype 2 Streptococcus pneumoniae D39 or Escherichia coli K-12 directly into the scala tympani of guinea pigs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d0499f081a8cbd958c6627bfa257eb
https://doi.org/10.1016/s0163-4453(98)93270-4
https://doi.org/10.1016/s0163-4453(98)93270-4
Publikováno v:
Acta Oto-Laryngologica. 118:673-680
The auditory brainstem response (ABR) technique was used to investigate potential dysfunctions in the auditory brainstem of the pigmented guinea pig (Cavia porcellus) associated with biological ageing. Animals aged from 58 days to 4 years 3 months we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a96a2d234181d3723ea000411258d6
https://doi.org/10.1080/00016489850183160
https://doi.org/10.1080/00016489850183160
Publikováno v:
Acta Oto-Laryngologica. 116:401-407
Experimental meningitis was induced in 16 pigmented guinea pigs by subarachnoid inoculation of mid log-phase 1 x 10(9) E. coli K-12 (n = 8) or 5 x 10(7) Streptococcus pneumoniae type 2 (n = 8). Animals were killed at various times between 3 and 12 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537b48a208649b592d7a16898e421dcf
https://doi.org/10.3109/00016489609137864
https://doi.org/10.3109/00016489609137864
Autor:
S. Stephensl, R. Jenkins, S. D. Comis, P. Stanley, J. Crocker, Michael P. Osborne, M J Tarlow
Publikováno v:
Neuropathology and Applied Neurobiology. 19:324-328
Tumour necrosis factor-alpha (TNF alpha) is a major proinflammatory cytokine which appears in the cerebrospinal fluid very early after endotoxin challenge, and is likely to be produced locally. Following in vivo and in vitro challenge with endotoxin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2593dbff900b5594d41c176223f0d35
https://doi.org/10.1111/j.1365-2990.1993.tb00447.x
https://doi.org/10.1111/j.1365-2990.1993.tb00447.x
Publikováno v:
Acta Oto-Laryngologica. 109:361-368
Human labyrinths were fixed with glutaraldehyde as soon as possible and certainly within 15 min of clinically confirmed death. By following this protocol, we have obtained excellent preservation of human material comparable to the best that we were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7113a477b2d16d64d51997c4af07dd90
https://doi.org/10.3109/00016489009125156
https://doi.org/10.3109/00016489009125156
Publikováno v:
Acta oto-laryngologica. 117(3)
Microperfusion of scala tympani with the NO donors, sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP), produced marked depression of the compound action potential (CAP) and cochlear microphonic (CM) together with severe and widesp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b412e5e2c5641b82bf6431d577b3928
https://pubmed.ncbi.nlm.nih.gov/9199517
https://pubmed.ncbi.nlm.nih.gov/9199517
Publikováno v:
International journal of experimental pathology. 76(5)
Sensorineural hearing loss was studied in a rabbit model of experimental bacterial meningitis using electrophysiological and ultrastructural techniques. Hearing impairment was monitored by auditory brain-stem evoked responses (ABERs) and concomitant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c076053e3a03b4cc7c111f48c82246d3
https://pubmed.ncbi.nlm.nih.gov/7488546
https://pubmed.ncbi.nlm.nih.gov/7488546
Publikováno v:
Acta oto-laryngologica. 115(3)
Sensorineural hearing loss is a major sequela of the bacterial meningitis associated in particular with Streptococcus pneumoniae. Recent studies have shown pneumolysin, a toxin elaborated by S. pneumoniae, to be cytotoxic to the guinea pig cochlea. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad58c76fb4d2ba2a316c1fffb2c26d0
https://pubmed.ncbi.nlm.nih.gov/7544527
https://pubmed.ncbi.nlm.nih.gov/7544527
Autor:
Graham J. Boulnois, Peter W. Andrew, T.L. Hayward, Michael P. Osborne, John Stephen, M J Tarlow, S. D. Comis, Timothy J. Mitchell
Publikováno v:
Acta oto-laryngologica. 113(2)
The cytolytic toxin, pneumolysin, from the gram positive bacterium, Streptococcus pneumoniae, when perfused through the scala tympani of the guinea pig cochlea reduced the amplitude of both the compound action potential and the cochlear microphonic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d742dd79022d33943afb5756d225094
https://pubmed.ncbi.nlm.nih.gov/8475728
https://pubmed.ncbi.nlm.nih.gov/8475728