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Autor: P K. Moore, S D. Brain, P K. Towler, G S. Bennett

Publikováno v: NeuroReport. 9:1513-1518

The effects of a neuronal nitric oxide synthase (nNOS) inhibitor, 1-(2-trifluoromethylphenyl)imidazole (TRIM) on rat sensory saphenous nerve-induced neurogenic inflammation were investigated. TRIM (50 mg kg-1, i.p.), but not 2-trifluoromethylphenol (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c3b0fd2ca33e5ad1f902e6cec873b9
https://doi.org/10.1097/00001756-199805110-00049

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Effect of the inducible nitric oxide synthase inhibitors aminoguanidine and L-N6-(1-iminoethyl)lysine on zymosan-induced plasma extravasation in rat skin

Autor: V C Ridger, E R Pettipher, C E Bryant, S D Brain

Publikováno v: The Journal of Immunology. 159:383-390

The effect of nitric oxide synthase (NOS) inhibitors on plasma extravasation in a rat model of zymosan-induced inflammation has been investigated. Plasma extravasation was determined in response to intradermal test agents over 0 to 45 min or 0 to 4 h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d98a5d2f2b51d4f422c9803b33d97e9a
https://doi.org/10.4049/jimmunol.159.1.383

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Transient receptor potential ankyrin 1: emerging pharmacology and indications for cardiovascular biology

Autor: J V, Bodkin, S D, Brain

Publikováno v: Acta physiologica (Oxford, England). 203(1)

Transient receptor potential anykrin 1 (TRPA1) is a member of the TRP superfamily, representing the sole member of the TRPA subfamily. It has many identified endogenous and exogenous agonists, comprising largely of chemical irritants and products of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21c5465da6a062d78fe95dc489805de9
https://pubmed.ncbi.nlm.nih.gov/20950342

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Calcitonin gene-related peptide-induced suppression of luteinizing hormone pulses in the rat: the role of endogenous opioid peptides

Autor: J E, Bowe, X F, Li, J S, Kinsey-Jones, S, Paterson, S D, Brain, S L, Lightman, K T, O'Byrne

Publikováno v: The Journal of physiology. 566(Pt 3)

Calcitonin gene-related peptide (CGRP) is involved in a variety of stress responses in the rat. Central administration of CGRP activates the hypothalamo-pituitary-adrenal axis resulting in increased corticosterone secretion. We have previously shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b29caf43cc743f05b59c152e037ef68c
https://pubmed.ncbi.nlm.nih.gov/15905218

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The calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS blocks CGRP and adrenomedullin vasoactive responses in the microvasculature

Autor: A D, Grant, C W, Tam, Z, Lazar, M K, Shih, S D, Brain

Publikováno v: British journal of pharmacology. 142(7)

Calcitonin gene-related peptide (CGRP) is a potent microvascular dilator neuropeptide that is considered to play an essential role in neurogenic vasodilatation and in maintaining functional integrity in peripheral tissues. We have examined the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85c284a3ce39bec6597d22fa3c7cdd5f
https://pubmed.ncbi.nlm.nih.gov/15237099

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Protein nitration in cutaneous inflammation in the rat: essential role of inducible nitric oxide synthase and polymorphonuclear leukocytes

Autor: S A B, Greenacre, F A C, Rocha, A, Rawlingson, S, Meinerikandathevan, R N, Poston, E, Ruiz, B, Halliwell, S D, Brain

Publikováno v: British journal of pharmacology. 136(7)

1: We have examined the relationship between neutrophil accumulation, NO(*) production and nitrated protein levels in zymosan-mediated inflammation in rat skin in vivo. 2: Rats were anaesthetized and cutaneous inflammation was induced by zymosan (inj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b1c0e2c9e3ffdd01e99600ee342f876
https://pubmed.ncbi.nlm.nih.gov/12145098

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The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells

Autor: L C, Esquisatto, S K, Costa, E A, Camargo, M T, Ribela, S D, Brain, G, de Nucci, E, Antunes

Publikováno v: British journal of pharmacology. 134(1)

1. The contribution of sensory neurons and mast cells to the oedema evoked by adenosine A1 (N(6)-cyclopentyladenosine, CPA, 3 - 30 nmol site(-1)), A2 (5'N-ethylcarboxamidoadenosine, NECA, 1 - 10 nmol site(-1)) and A3 receptor agonists (N6-[3-iodobenz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89f4d6dd5c6c35f9bec5ebbf0716b8c8
https://pubmed.ncbi.nlm.nih.gov/11522602

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A comparative study of the ability of calcitonin gene-related peptide and adrenomedullin(13 - 52) to modulate microvascular but not thermal hyperalgesia responses

Autor: D Q, Chu, M, Choy, P, Foster, T, Cao, S D, Brain

Publikováno v: British journal of pharmacology. 130(7)

Calcitonin gene-related peptide (CGRP), a neuropeptide, is a potent vasodilator. Adrenomedullin (ADM) is suggested to be produced by vascular cells in inflamed tissue. ADM shares some structural homology with CGRP. We have compared the ability of CGR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f915d51c1f570591edaae0f5fc0e4a8
https://pubmed.ncbi.nlm.nih.gov/10928962

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