Zobrazeno 1 - 10
of 455
pro vyhledávání: '"S. Crabb"'
Autor:
Geeng-Fu Jang, John S. Crabb, Allison Grenell, Alyson Wolk, Christie Campla, Shiming Luo, Mariya Ali, Bo Hu, Belinda Willard, Bela Anand-Apte
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background Sex as a biological variable is not a common consideration in molecular mechanistic or preclinical studies of retinal diseases. Understanding the sexual dimorphism of adult RPE and retina under physiological conditions is an impor
Externí odkaz:
https://doaj.org/article/365d699ba72941d99ccd615aeb44498c
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. H
Externí odkaz:
https://doaj.org/article/ff89181888414cdebed058704ff392b1
Autor:
Allison Grenell, Charandeep Singh, Monisha Raju, Alyson Wolk, Sonal Dalvi, Geeng-Fu Jang, John S. Crabb, Courtney E. Hershberger, Kannan V. Manian, Karen Hernandez, John W. Crabb, Ruchira Singh, Jianhai Du, Bela Anand-Apte
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 101995- (2024)
Objectives: Mutations in Tissue Inhibitor of Metalloproteinases 3 (TIMP3) cause Sorsby's Fundus Dystrophy (SFD), a dominantly inherited, rare form of macular degeneration that results in vision loss. TIMP3 is synthesized primarily by retinal pigment
Externí odkaz:
https://doaj.org/article/b2e34dbdf5864329895d170e3ed2ee8a
Autor:
Madeline G. Dans, Coralie Boulet, Gabrielle M. Watson, William Nguyen, Jerzy M. Dziekan, Cindy Evelyn, Kitsanapong Reaksudsan, Somya Mehra, Zahra Razook, Niall D. Geoghegan, Michael J. Mlodzianoski, Christopher Dean Goodman, Dawson B. Ling, Thorey K. Jonsdottir, Joshua Tong, Mufuliat Toyin Famodimu, Mojca Kristan, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Colin J. Sutherland, Michael J. Delves, Geoffrey I. McFadden, Alyssa E. Barry, Brendan S. Crabb, Tania F. de Koning-Ward, Kelly L. Rogers, Alan F. Cowman, Wai-Hong Tham, Brad E. Sleebs, Paul R. Gilson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/36bf3afec36e4aac961dcc7fb75d1e5e
Autor:
Greta E Weiss, Robert J Ragotte, Doris Quinkert, Amelia M Lias, Madeline G Dans, Coralie Boulet, Oliver Looker, Olivia D Ventura, Barnabas G Williams, Brendan S Crabb, Simon J Draper, Paul R Gilson
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011182 (2023)
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the current leading blood-stage malaria vaccine candidate. PfRH5 functions as part of the pentameric PCRCR complex containing PTRAMP, CSS, PfCyRPA and PfRIPR, all of which ar
Externí odkaz:
https://doaj.org/article/860d3157d96a47f895c9adb7940cc078
Autor:
Donya Eghrari, Michelle J. L. Scoullar, Alyce N. Wilson, Elizabeth Peach, Arthur Elijah, Pele Melepia, Hadlee SupSup, Lisa M. Vallely, Peter M. Siba, Elissa C. Kennedy, Joshua P. Vogel, Caroline S. E. Homer, Leanne J. Robinson, Freya J. I. Fowkes, William Pomat, Brendan S. Crabb, James G. Beeson, Christopher J. Morgan
Publikováno v:
BMC Pregnancy and Childbirth, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background Globally, 2.5 million babies die in the first 28 days of life each year with most of these deaths occurring in low- and middle-income countries. Early recognition of newborn danger signs is important in prompting timely care seeki
Externí odkaz:
https://doaj.org/article/d86078a3e362468fbd21f52d73b338dc
Autor:
Molly Parkyn Schneider, Oliver Looker, Maria Rebelo, David S. Khoury, Matthew W. A. Dixon, Claude Oeuvray, Brendan S. Crabb, James McCarthy, Paul R. Gilson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
M5717 is a promising antimalarial drug under development that acts against multiple stages of the life cycle of Plasmodium parasites by inhibiting the translation elongation factor 2 (PfeEF2), thereby preventing protein synthesis. The parasite cleara
Externí odkaz:
https://doaj.org/article/c2406534d5854e6ab1c7c2aaa0f7936b
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background The city of Melbourne, Australia experienced two waves of the COVID-19 epidemic peaking, the first in March and a more substantial wave in July 2020. During the second wave, a series of control measure were progressively introduce
Externí odkaz:
https://doaj.org/article/e635ca35dbaf454e9d6f56f033f3e86c
Autor:
Madeline G Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Niall D Geoghegan, Aurelie T Dawson, Sujaan Das, Molly Parkyn Schneider, Thorey K Jonsdottir, Mikha Gabriela, Maria R Gancheva, Christopher J Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I McFadden, Danny W Wilson, Kelly L Rogers, Alyssa E Barry, Brendan S Crabb, Tania F de Koning-Ward, Brad E Sleebs, Inari Kursula, Paul R Gilson
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002066 (2023)
With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and
Externí odkaz:
https://doaj.org/article/d4ae40a3c3394669ac6efd4a149b5ec0
Autor:
Claudia B. G. Barnes, Madeline G. Dans, Thorey K. Jonsdottir, Brendan S. Crabb, Paul R. Gilson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The cation efflux pump Plasmodium falciparum ATPase 4 (PfATP4) maintains Na+ homeostasis in malaria parasites and has been implicated in the mechanism of action of many structurally diverse antimalarial agents, including >7% of the antimalarial compo
Externí odkaz:
https://doaj.org/article/08cdd3cfaeed4e469e4110a4b51aef51