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Autor:
J. Hudson, Ivor J. Benjamin, Qiang Dai, Justin L. P. Benesch, Elisabeth S. Christians, Rita Barresi, Alex C. Minella, Michael Grzybowski, Kate Bushby, Aron M. Geurts, Pattraranee Limphong, Elizabeth Wraige, Michael Riedel, Heinz Jungbluth, Mai T. Thao, Frances D.L. Kondrat, Shuping Lai, Huali Zhang, Melinda J. Choi, Wai-Meng Kwok, Qiang Lui, Graydon Taylor, Kurt D. Kolander, Katie A. Mitzelfelt
Publikováno v:
Mitzelfelt, K A, Limphong, P, Choi, M J, Kondrat, F D L, Lai, S, Kolander, K D, Kwok, W-M, Dai, Q, Grzybowski, M N, Zhang, H, Taylor, G M, Lui, Q, Thao, M T, Hudson, J A, Barresi, R, Bushby, K, Jungbluth, H, Wraige, E, Geurts, A M, Benesch, J L P, Riedel, M, Christians, E S, Minella, A C & Benjamin, I J 2016, ' Human 343delT HSPB5 Chaperone associated with Early-onset Skeletal Myopathy causes Defects in Protein Solubility ', Journal of Biological Chemistry . https://doi.org/10.1074/jbc.M116.730481
Mutations of HSPB5 (also known as CRYAB or αB-crystallin), a bona fide heat shock protein and molecular chaperone encoded by the HSPB5 (crystallin, alpha B) gene, are linked to various multisystem disorders featuring variable combinations of catarac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85b51dad93daa504c4b792be2ca5fe7
https://doi.org/10.1074/jbc.m116.730481
https://doi.org/10.1074/jbc.m116.730481
Autor:
Elisabeth S, Christians
Publikováno v:
Advances in anatomy, embryology, and cell biology. 222
Early embryos develop from fertilized eggs using materials that are stored during oocyte growth and which can be defined as maternal contribution (molecules, factors, or determinants). Several heat shock proteins (HSPs) and the heat shock transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d476156b2fce3c68213e57bca2597ea3
https://pubmed.ncbi.nlm.nih.gov/28389748
https://pubmed.ncbi.nlm.nih.gov/28389748
Publikováno v:
Current Protein & Peptide Science. 15:189-204
Cardiomyocytes are best known for their spontaneous beating activity, large cell size, and low regenerative capacity during adulthood. The mechanical activity of cardiomyocytes depends on a sophisticated contractile apparatus comprised of sarcomeres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08e5feba2bfc44fa6b85351f423a03c
https://doi.org/10.2174/1389203715666140331111518
https://doi.org/10.2174/1389203715666140331111518
Autor:
B. Rosati, S. Isokääntä, S. Christiansen, M. M. Jensen, S. P. Moosakutty, R. Wollesen de Jonge, A. Massling, M. Glasius, J. Elm, A. Virtanen, M. Bilde
Publikováno v:
Atmospheric Chemistry and Physics, Vol 22, Pp 13449-13466 (2022)
Dimethyl sulfide (DMS) is emitted by phytoplankton species in the oceans and constitutes the largest source of naturally emitted sulfur to the atmosphere. The climate impact of secondary particles, formed through the oxidation of DMS by hydroxyl radi
Externí odkaz:
https://doaj.org/article/b8675612424849b2b3b887a5795611b8
Publikováno v:
Pharmeuropa bioscientific notes. 2016
Molecular-size distribution by size-exclusion chromatography (SEC) [1] is used for the quantification of unwanted aggregated forms in therapeutic polyclonal antibodies, referred to as human immunoglobulins (Ig) in the European Pharmacopoeia. Consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1762a9981208aa4547fb54b80903ccd3
https://pubmed.ncbi.nlm.nih.gov/27593533
https://pubmed.ncbi.nlm.nih.gov/27593533
Publikováno v:
Pharmeuropa bioscientific notes. 2015
Due to the diminished stocks of the 2nd batch of the European Pharmacopoeia (Ph. Eur.) Biological Reference Preparation (BRP) for human albumin for electrophoresis, the European Directorate for the Quality of MedicinesHealthCare (EDQM) initiated in 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd52c6c4dcff235b0d0dce4850434536
https://pubmed.ncbi.nlm.nih.gov/26830166
https://pubmed.ncbi.nlm.nih.gov/26830166
Autor:
Benjamin Wolozin, Andrew A. Wilson, Anatoli B. Meriin, Vladimir L. Gabai, Ivor J. Benjamin, Elisabeth S. Christians, Michael Y. Sherman, Geunwon Kim
Publikováno v:
Aging Cell. 11:617-627
Heat shock response (HSR) that protects cells from proteotoxic stresses is downregulated in aging, as well as upon replicative senescence of cells in culture. Here we demonstrate that HSR is suppressed in fibroblasts from the patients with segmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::225aefb94611865fe1f63f1e21892625
https://doi.org/10.1111/j.1474-9726.2012.00827.x
https://doi.org/10.1111/j.1474-9726.2012.00827.x
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 302:H24-H37
Force-generating contractile cells of the myocardium must achieve and maintain their primary function as an efficient mechanical pump over the life span of the organism. Because only half of the cardiomyocytes can be replaced during the entire human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f7f289e1ce7f7da34a1aa1330c9129
https://doi.org/10.1152/ajpheart.00903.2011
https://doi.org/10.1152/ajpheart.00903.2011
Autor:
Huali Zhang, Pattraranee Limphong, Qiang Liu, Joel Pieper, Elisabeth S. Christians, Christopher K. Rodesch, Ivor J. Benjamin
Publikováno v:
The FASEB Journal. 26:1442-1451
To investigate the effects of the predominant nonprotein thiol, glutathione (GSH), on redox homeostasis, we employed complementary pharmacological and genetic strategies to determine the consequences of both loss- and gain-of-function GSH content in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a41e7e970242ee1e3e21aa935c93f5
https://doi.org/10.1096/fj.11-199869
https://doi.org/10.1096/fj.11-199869