Zobrazeno 1 - 10
of 214
pro vyhledávání: '"S. Charleston"'
Autor:
L. E. Mendez-Magdaleno, G. Dorantes-Mendez, S. Charleston-Villalobos, T. Aljama-Corrales, J. Gonzalez-Hermosillo, R. Gonzalez-Camarena
Publikováno v:
Fluctuation and Noise Letters. 22
Orthostatic stress via a head-up tilt test (HUTT) has been clinically used to rule out vasovagal syncope (VVS), which is generated by an inappropriate autonomic nervous system (ANS) regulation. VVS has been evaluated mainly by hemodynamic variables a
Autor:
Travis K Warren, Chris A Whitehouse, Jay Wells, Lisa Welch, Jay S Charleston, Alison Heald, Donald K Nichols, Marc E Mattix, Gustavo Palacios, Jeffrey R Kugleman, Patrick L Iversen, Sina Bavari
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004456 (2016)
Marburg virus (MARV) is an Ebola-like virus in the family Filovirdae that causes sporadic outbreaks of severe hemorrhagic fever with a case fatality rate as high as 90%. AVI-7288, a positively charged antisense phosphorodiamidate morpholino oligomer
Externí odkaz:
https://doaj.org/article/c8b3af9a51de44cb95f7da37c00b05f2
Autor:
Travis K. Warren, Chris A. Whitehouse, Jay Wells, Lisa Welch, Alison E. Heald, Jay S. Charleston, Pete Sazani, St. Patrick Reid, Patrick L. Iversen, Sina Bavari
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
ABSTRACT Ebola viruses (EBOV) cause severe disease in humans and nonhuman primates with high mortality rates and continue to emerge in new geographic locations, including several countries in West Africa, the site of a large ongoing outbreak. Phospho
Externí odkaz:
https://doaj.org/article/19d856969d434bf7a60886a465bb16a6
Autor:
Diane E, Frank, Frederick J, Schnell, Cody, Akana, Saleh H, El-Husayni, Cody A, Desjardins, Jennifer, Morgan, Jay S, Charleston, Valentina, Sardone, Joana, Domingos, George, Dickson, Volker, Straub, Michela, Guglieri, Eugenio, Mercuri, Laurent, Servais, Francesco, Muntoni, Shande, Tang
Publikováno v:
Neurology
ObjectiveTo report safety, pharmacokinetics, exon 53 skipping, and dystrophin expression in golodirsen-treated patients with Duchenne muscular dystrophy (DMD) amenable to exon 53 skipping.MethodsPart 1 was a randomized, double-blind, placebo-controll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c84c101e1b3dd57b3ae451d3f1d9037
https://ora.ox.ac.uk/objects/uuid:a45c718a-1957-463b-bd36-efe91be71e85
https://ora.ox.ac.uk/objects/uuid:a45c718a-1957-463b-bd36-efe91be71e85
Autor:
S, Reulecke, S, Charleston-Villalobos, T, Aljama-Corrales, A, Voss, R, Gonzalez-Camarena, M, Gaitan-Gonzalez, J, Gonzalez-Hermosillo, G, Hernandez-Pacheco
Publikováno v:
EMBC
The aim of this study was to investigate the temporal dynamic behavior of cardiovascular interactions between heart period and systolic blood pressure during a 20-min head-up tilt test at 70° in young women with orthostatic intolerance compared to h
Autor:
Johannes Dworzak, Daniel G. Rudmann, Famke Aeffner, Kristin Wilson, Crystal Faelan, Suzanne Kanaly, Manish Ranjitkar, Holger Lange, J Kris Piper, Steven A. Moore, Joshua C. Black, Anthony J. Milici, D. Frank, Jay S. Charleston, G. David Young, Alexander Moody
Publikováno v:
Archives of Pathology & Laboratory Medicine. 143:197-205
Context.—Duchenne muscular dystrophy is a rare, progressive, and fatal neuromuscular disease caused by dystrophin protein loss. Common investigational treatment approaches aim at increasing dystrophin expression in diseased muscle. Some clinical tr
Autor:
Frederick J. Schnell, Amy Flynt, Jessie Lynch, Helen Eliopoulos, Cas Donoghue, Linda Lowes, Jerry R. Mendell, Anthony J. Milici, Emily Naughton, D. Frank, Sarah Lewis, Johannes Dworzak, Karin Lucas, Zarife Sahenk, Robert Dracker, Linda H. Cripe, Jay S. Charleston, G. David Young, Anne M. Connolly, Lindsay N. Alfano, Louise R. Rodino-Klapac
Publikováno v:
Medicine
This analysis aims to describe the outcomes of two nonambulatory patients with Duchenne muscular dystrophy (DMD) who participated in two clinical studies. The two consecutive trials of eteplirsen (studies 201 and 202) were conducted in patients with
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Autor:
Courtney Shanks, Jianbo Zhang, Mark G. Mense, Alok K. Sharma, Michael P. Carver, Harjeet Kaur, Jay S. Charleston, Peter Sazani
Publikováno v:
Journal of Neuromuscular Diseases. 3:381-393
Background Phosphorodiamidate morpholino oligomers (PMOs) are a class of exon skipping drugs including eteplirsen, which has shown considerable promise for treatment of the degenerative neuromuscular disease, Duchenne musculardystrophy (DMD). Objecti
Autor:
Kelly L. Warfield, Peter Sazani, Jay S. Charleston, Sina Bavari, Edward M. Kaye, Travis K. Warren, Alison E. Heald, Jay B. Saoud, Michael Wong, Lisa S. Welch, Jay Wells, Dana L. Swenson, Mohamed Al-Ibrahim, Patrick L. Iversen, Diane Berry
Publikováno v:
New England Journal of Medicine. 373:339-348
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.We assessed the efficacy of AVI-7288 in a series of