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NOTCH1 drives immune-escape mechanisms in B cell malignancies

Autor: I. Moutsoupoulos, Chandra Sekhar Reddy Chilamakuri, Junyan Lu, Irina Mohorianu, S. Deaglio, Thorsten Zenz, José I. Martín-Subero, Anthony T. Moore, V. N. Roamio Franklin, S. Charalampopoulou, Andreas Rosenwald, Maurizio Mangolini, Ingo Ringshausen, A. Maiques-Diaz, S. Stilgenbauer, E. Gerhard-Hartmann, Clive D'Santos, Johannes Bloehdorn

NOTCH1 is a recurrently mutated gene in Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL). Functional studies to investigate its role have been hampered by the inability to genetically manipulate primary human lymphoma cells, attribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57b80f13809206e9e67d86c7ce90908b
https://doi.org/10.1101/2021.04.10.439192

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Epigenetic features support the diagnosis of B-cell prolymphocytic leukemia and identify two clinico-biological subtypes.

Autor: Charalampopoulou S; IDIBAPS, Barcelona, Spain., Chapiro E; AP-HP, PARIS, France., Nadeu F; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Zenz T; University of Zurich, Zürich, Switzerland., Beà S; IDIBAPS, Barcelona, Spain., Aymerich M; Hospital Clínic of Barcelona, Barcelona, Spain., Martinez-Farran A; IDIBAPS, Barcelona, Spain., Rozman M; Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain., Roos-Weil D; Pitié-Salpêtrière, paris, France., Bernard OA; INSERM, Villejuif cedex, France., Susin SA; Centre de Recherche des Cordeliers, Paris, France., Parker H; University of Southampton, Southampton, United Kingdom., Walewska R; University Hospitals Dorset, Bournemouth, United Kingdom., Oakes CC; The Ohio State University, Columbus, Ohio, United States., Strefford JCC; University of Southampton, Southampton, United Kingdom., Campo E; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Matutes E; Hospital Clinic. University of Barcelona, Barcelona, Spain., Duran-Ferrer M; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Nguyen-Khac F; Hopital Pitie-Salpetriere, Sorbonne Universite, Paris, France., Martin-Subero JI; IDIBAPS, Barcelona, Spain.

Publikováno v: Blood advances [Blood Adv] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.