Zobrazeno 1 - 10
of 63
pro vyhledávání: '"S. C. van Buul-Offers"'
Publikováno v:
Journal of Endocrinology. 182:445-455
The insulin-like growth factors, IGF-I and IGF-II, and their binding proteins play an important role in the growth and development of the central nervous system. In the brain, colocalization of IGFs and IGFBPs often occurs, suggesting that IGFBPs can
Autor:
J.G. Koster, R.E. Reddingius, R.J. Bloemen, S. C. van Buul-Offers, J. van Doorn, MG Gresnigt, H.J. Gilhuis, G.N.P. van Muijen, Pieter Wesseling
Publikováno v:
Neuropathology and Applied Neurobiology. 30:503-512
Insulin-like growth factors (IGFs) play an important role in tumour growth and development. We hypothesized that this is also the case for medulloblastomas, which are highly malignant cerebellar brain tumours usually occurring in children. In these t
Autor:
C.E. van den Brink, S. C. van Buul-Offers, B. van der Burg, Brenda I. Hendriks-Stegeman, P. T. Van Der Saag, Maarten Jansen, Harry Vermeer
Publikováno v:
Clinical Endocrinology. 59:49-55
Summary objective Some patients develop side-effects even on relatively low doses of topically administered glucocorticoids (GCs), while others appear to be less sensitive to GCs. We have developed and validated a bioassay which can measure glucocort
Publikováno v:
Clinical Endocrinology. 54:655-664
OBJECTIVE Insulin-like growth factor binding protein-4 (IGFBP-4) belongs to a family of six structurally related IGF-binding proteins that are involved in the modulation of the biological effects of the IGFs. In order to obtain more insight into the
Autor:
M. Van Kleffens, C. M. Hoogerbrugge, S. C. van Buul-Offers, JA Koedam, M. G. Gresnigt, Dicky J. Lindenbergh-Kortleve, J.W. van Neck, R. J. Bloemen, Stenvert L. S. Drop, J. G. Koster
Publikováno v:
Endocrinology. 141:1493-1499
The actions of insulin-like growth factor-I (IGF-I) are modulated by IGF binding proteins (IGFBPs). The effects of IGFBP-1 in vivo are insufficiently known, with respect to inhibitory or stimulatory actions on IGF-induced growth of specific organs. T
Publikováno v:
Journal of Endocrinology. 163:543-552
The physiological role of IGF-II remains unclear but there is evidence for a role in postnatal growth, the growth of the thymus and bone homeostasis. Glucocorticoids have many effects that are opposite to the effects of IGF-II such as growth retardat
Autor:
S C van Buul-Offers, A. M. Ringeling, J. Van Doorn, S. S. Shmueli, Anita C. S. Hokken-Koelega, M. Jansen, M. C. Kuijpers
Publikováno v:
Clinical Endocrinology. 50:601-609
Objective Insulin-like growth factor binding protein-6 (IGFBP-6) is a relatively unknown member of a family of six specific structurally related IGF binding proteins which are involved in the modulation of the biological effects of the IGFs. A distin
Autor:
S C van Buul-Offers, Ron Kooijman
Publikováno v:
Cellular and Molecular Life Sciences CMLS. 54:1083-1094
Growth hormone (GH) and insulin-like growth factor I (IGF-I) can modulate the development and function of the immune system. In this chapter, we present data on the expression of receptors for GH and IGFs and the in vitro and in vivo effects of these
Publikováno v:
Journal of Endocrinology. 153:87-97
The availability and activity of insulin-like growth factors (IGF-I and IGF-II) are largely determined by a group of IGF-binding proteins (IGFBPs). We have developed a new assay to characterize the interaction between the IGFs and IGFBP-3. In this as
Autor:
Marij J. P. Welters, P. J. M. Roholl, J. A. J. Faber, S. C. van Buul-Offers, W. Den Otter, L. T. M. Van Der Ven, John S. Sussenbach, T. Gloudemans, B. A. Bladergroen
Publikováno v:
British Journal of Cancer
To assess the role of insulin-like growth factors (IGFs) in growth and transformation of normal (myometrium) and tumorous smooth muscle cell (SMC) tissues, in situ hybridization (ISH) analysis for insulin-like growth factor I and II (IGF-I and IGF-II