Zobrazeno 1 - 10
of 18
pro vyhledávání: '"S. C. Sutton"'
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 35:11-16
The occurrence of drugs and drug formulations associated with large intrasubject pharmacokinetic (PK) variability has been well described in humans and is likewise encountered in veterinary medicine. The scaled average bioequivalence (SABE) approach
Publikováno v:
Journal of veterinary pharmacology and therapeutics. 35
The occurrence of drugs and drug formulations associated with large intrasubject pharmacokinetic (PK) variability has been well described in humans and is likewise encountered in veterinary medicine. The scaled average bioequivalence (SABE) approach
Publikováno v:
Pharmaceutical research. 13(10)
Publikováno v:
Pharmaceutical research. 13(10)
The current animal model generally accepted by the pharmaceutical industry and the FDA for assessment of muscle damage following intramuscular injection (IM) is the rabbit lesion volume model (RbLV). However, this model is resource intensive. The goa
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 22(3)
Recently, analytical methods have become available for determination of both the lactone (active form) and the carboxylate (inactive form) forms of 20(S)-camptothecin in biological fluids. Studies in our laboratory have shown that there are significa
Autor:
H, Cheng, S C, Sutton, J D, Pipkin, G M, Zentner, J D, Rogers, J I, Schwartz, Y B, Mitchel, K, Grasing, M S, Schwartz, R D, Amin
Publikováno v:
Pharmaceutical research. 10(11)
Seven sustained/controlled-release dosage forms were designed for gastrointestinal delivery of lovastatin or simvastatin, two potent HMG-CoA reductase inhibitors for the treatment of hypercholesterolemia. The in vivo performance of these formulations
Publikováno v:
Pharmaceutical research. 10(10)
The performance of tablets containing the absorption enhancer palmitoylcarnitine chloride (PCC) and the antibiotic cefoxitin (CEF) was determined by direct placement of tablets in the rat stomach, small intestine, and colon. While the bioavailability
Publikováno v:
Pharmaceutical research. 10(6)
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 265(2)
Absorption-enhancing properties of the long-chain acylcarnitines (C12-C18) were examined in vitro utilizing a modified Sweetana-Grass diffusion cell system. Transepithelial electrical resistance (TEER) and drug permeability (P) of rat colonic mucosa
Publikováno v:
Pharmaceutical research. 9(3)
A simple modification of the commercially available Sweetana-Grass (S-G) side-by-side diffusion cells, allowing the simultaneous measurement of tissue permeability and transepithelial electrical resistance (TEER), has been described and validated for