Výsledky vyhledávání - "S. C. Sicher"

Differential regulation of Ia expression and antigen presentation by listeriolysin-producing versus non-producing strains of Listeria monocytogenes

Autor: M. L. Proctor, Christopher Y. Lu, S. C. Sicher, Miguel A. Vazquez, J. C. Crowley

Publikováno v: Journal of Leukocyte Biology. 59:683-690

listeria monocytogenes is an intracellular bacterial pathogen. A single gene product, listeriolysin (LLO), is critical for the induction of protective immunity. We now show that listeria that produce functional LLO augment Ia expression by macrophage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc05e72cb09ff6e44ffbf17c041de4bc
https://doi.org/10.1002/jlb.59.5.683

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Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils

Autor: G. W. Chung, Christopher Y. Lu, Miguel A. Vazquez, K. Kitamura, K. A. Stallworth, Tarik A. Khair-El-Din, S. C. Sicher, R. T. Miller

Publikováno v: The Journal of Experimental Medicine

Macrophage activation is deficient in the fetus and neonate when the serum concentrations of docosahexaenoic acid (DHA) are 150 microM, or 10-50-fold higher than in the adult. We now show that DHA inhibits production of nitric oxide (NO) by macrophag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d17a82eabd4e5965cdcfdb8882b7e87
https://doi.org/10.1084/jem.183.3.1241

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Augmentation or inhibition of IFN-gamma-induced MHC class II expression by lipopolysaccharides. The roles of TNF-alpha and nitric oxide, and the importance of the sequence of signaling

Autor: S C Sicher, G W Chung, M A Vazquez, C Y Lu

Publikováno v: The Journal of Immunology. 155:5826-5834

MHC class II expression on macrophages is one determinant of Ag presentation and the vigor of CD4+ T cell immunity. We show that LPS may either inhibit or augment IFN-gamma-induced MHC class II on macrophages depending on the sequence of the IFN-gamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f7751e7df3c28c03d271e08aa5b8a41
https://doi.org/10.4049/jimmunol.155.12.5826

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Docosahexaenoic acid, a major constituent of fetal serum and fish oil diets, inhibits IFN gamma-induced Ia-expression by murine macrophages in vitro

Autor: T A Khair-el-Din, S C Sicher, M A Vazquez, W J Wright, C Y Lu

Publikováno v: The Journal of Immunology. 154:1296-1306

Decreased Ia expression by macrophages may account for the increased susceptibility of fetuses and neonates to infection. We chose to investigate the role of docosahexaenoic acid (DHA), an omega-3 fatty acid, on Ia expression in vitro, because neonat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db92e0d378cd14c2a3cb34e38bc5dc54
https://doi.org/10.4049/jimmunol.154.3.1296

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Inhibition of macrophage Ia expression by nitric oxide

Autor: S C Sicher, M A Vazquez, C Y Lu

Publikováno v: The Journal of Immunology. 153:1293-1300

Bacterial LPS inhibits the expression of Ia by macrophages stimulated by IFN-gamma. We now present the following observations that suggest a causal relationship between nitric oxide (NO) and this inhibition of Ia expression: 1) NO production precedes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42216ae6b501c63c9dc1453fbd1896f6
https://doi.org/10.4049/jimmunol.153.3.1293

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Nitric oxide inhibits INFgamma-induced increases in CIITA mRNA abundance and activation of CIITA dependent genes--class II MHC, Ii and H-2M. Class II TransActivator

Autor: M L, Kielar, S C, Sicher, J G, Penfield, D R, Jeyarajah, C Y, Lu

Publikováno v: Inflammation. 24(5)

Nitric oxide (NO) has been recently implicated as a powerful inhibitor of immune responses during allograft rejection, and some autoimmune and infectious diseases. We previously showed that one potential regulatory effect of NO is inhibition of IFNga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e7d2128c2639d1dcd72291be9f23ccc
https://pubmed.ncbi.nlm.nih.gov/10921507

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Augmentation or inhibition of IFN-gamma-induced MHC class II expression by lipopolysaccharides. The roles of TNF-alpha and nitric oxide, and the importance of the sequence of signaling

Autor: S C, Sicher, G W, Chung, M A, Vazquez, C Y, Lu

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 155(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25c38256997894cdbd1fd686ee9685f8
https://pubmed.ncbi.nlm.nih.gov/7499872

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Docosahexaenoic acid, a major constituent of fetal serum and fish oil diets, inhibits IFN gamma-induced Ia-expression by murine macrophages in vitro

Autor: T A, Khair-el-Din, S C, Sicher, M A, Vazquez, W J, Wright, C Y, Lu

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 154(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::771c229fb55f7831c59c1924dd5613a7
https://pubmed.ncbi.nlm.nih.gov/7822798

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