Zobrazeno 1 - 10 of 90 pro vyhledávání: '"S. C. Schold"'
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Potentiation of BCNU antitumor efficacy by 9-substituted O 6-benzylguanines. Effect of metabolism
Autor: S. C. Schold, Anthony E. Pegg, Moschel Rc, Demetrius M. Kokkinakis
Publikováno v: Cancer Chemotherapy and Pharmacology. 45:69-77
Purpose: O6-Benzylguanine (BG), an O6-methylguanine-DNA methyltransferase (MGMT) inactivator, potentiates the efficacy of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and of other DNA chloroethylating and methylating anticancer drugs and is currently
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf985bc603801b4e2f67ec1e70ae0196
https://doi.org/10.1007/pl00006746
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4
Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma
Autor: James M. Pluda, DM Kokkinakis, Robert C. Moschel, ME Dolan, Michael M. Haglund, Henry S. Friedman, Darell D. Bigner, Jeremy N. Rich, Tracy Kerby, Allan H. Friedman, David M. Ashley, Ilkcan Cokgor, James E. Herndon, S. C. Schold, Roger E. McLendon, Anthony E. Pegg
Publikováno v: Journal of Clinical Oncology. 16:3570-3575
PURPOSE The major mechanism of resistance to alkylnitrosourea therapy is the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which removes chlorethylation or methylation damage from the O6-position of guanine. O6-benzylguanine (O6-BG)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b69dc7850cb4b909803065f9a6f4c3e
https://doi.org/10.1200/jco.1998.16.11.3570
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5
Glial Tumors in the MNU Rat Model: Induction of Pure and Mixed Gliomas that Do Not Require Typical Missense Mutations of p53
Autor: Elisabeth J. Rushing, S C Schold, K J Land, Mark L. Watson, Demetrius M. Kokkinakis
Publikováno v: Journal of Neuropathology and Experimental Neurology. 57:1053-1060
Gliomas were induced in adult male Sprague-Dawley rats by continuous exposure to 100 ppm of N-nitrosmethy-lurea (MNU) in drinking water. Latency periods for such tumors were 20 and SO weeks following completion of exposure intervals of 20, 15, and 10
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9f7985ca117ac33f12e928689c19fc
https://doi.org/10.1097/00005072-199811000-00008
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6
Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells
Autor: D. M. Kokkinakis, S. C. Schold, Thomas P. Brent, T. H. Vuong, M. A. von Wronski
Publikováno v: British Journal of Cancer
Methionine (MET)-dependent cell lines require MET to proliferate, and homocysteine (HCY) does not act as a substitute for this requirement. From six O6-methylguanine-DNA methyltransferase (MGMT)-efficient (mer+) cell lines tested, two medulloblastoma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7eb496a425293df85b3abcf359e5c0
http://europepmc.org/articles/PMC2063394
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7
Metabolism and Disposition of O6-Benzyl-2'-deoxyguanosine in Sprague-Dawley Rats
Autor: Moschel Rc, Anthony E. Pegg, M E Dolan, S. C. Schold, Demetrius M. Kokkinakis
Publikováno v: Chemical Research in Toxicology. 7:762-769
O6-Benzyl-2'-deoxyguanosine is a potential antitumor drug modulator that is intended to reduce or eliminate O6-alkylguanine-DNA alkyltransferase activity in tumors prior to treatment with genotoxic chemotherapeutic alkylating agents. The rationale fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d34e7da328b2cbc72663835276f0695
https://doi.org/10.1021/tx00042a008
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Effects of therapy on the 1H NMR spectrum of a human glioma line
Autor: S. Cazzaniga, S. C. Schold, Henry Dirk Sostman, H. Cecil Charles
Publikováno v: Magnetic Resonance Imaging. 12:945-950
Currently it is difficult to predict the efficacy of any therapeutic modality in individual patients. If it could be shown that successful therapy causes some chemical alteration in the tumor before gross alteration in size becomes radiologically vis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cfd7128ceb14341bc88d04c5bc32ae
https://doi.org/10.1016/0730-725x(94)92035-4
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9
Serial FDG-PET Studies in the Prediction of Survival in Patients with Primary Brain Tumors
Autor: S S Paine, Michael W. Hanson, Craig A. Beam, S. C. Schold, John M. Hoffman, Orest B. Boyko, T Schifter, R E Coleman, Peter C. Burger
Publikováno v: Journal of Computer Assisted Tomography. 17:509-516
OBJECTIVE This study examines the changes in tumor [18F]fluoro-2-deoxyglucose (FDG) uptake on serial FDG-PET studies and the ability of serial FDG-PET studies to predict survival in patients with treated and untreated primary brain tumors. MATERIALS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64386491ba098280bd3a230bd6b4d63f
https://doi.org/10.1097/00004728-199307000-00001
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10
Randomized comparison of diaziquone and carmustine in the treatment of adults with anaplastic glioma
Autor: Edward C. Halperin, R. Morawetz, D R Macdonald, E J Dropcho, James E. Herndon, Darell D. Bigner, Nicholas A. Vick, S. C. Schold, J G Cairncross, Peter C. Burger
Publikováno v: Journal of Clinical Oncology. 11:77-83
PURPOSE We conducted a phase III trial comparing intravenous (IV) diaziquone (AZQ) and carmustine (BCNU) as single agents in patients with cerebral anaplastic gliomas who had received surgery and radiotherapy. Its purpose was to compare the efficacy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1077e3514fad8d03504aa31098e672ea
https://doi.org/10.1200/jco.1993.11.1.77
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