Výsledky vyhledávání

Protein kinase C delta involvement in mammary tumor cell metastasis

Autor: S C, Kiley, K J, Clark, M, Goodnough, D R, Welch, S, Jaken

Publikováno v: Cancer research. 59(13)

Metastasis requires cytoskeletal remodeling for migration, adhesion, and extravasation of metastatic cells. Although protein kinase C (PKC) is involved in tumor promotion/progression and cytoskeletal remodeling, its role in metastasis has not been de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::668f211288c112f35a30cb1c3de8e6ef
https://pubmed.ncbi.nlm.nih.gov/10397270

Zobrazit plný text záznamu

Tetradecanoyl phorbol acetate-induced microtubule reorganization is required for sustained mitogen-activated protein kinase activation and morphological differentiation of U937 cells

Autor: R D, Whelan, S C, Kiley, P J, Parker

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(4)

Investigation of 12-tetradecanoyl phorbol 13-acetate (TPA)-resistant U937 cell clones has demonstrated that the normal sustained p42 mitogen-activated protein kinase (p42MAPK) activation produced by TPA treatment is absent. This is shown to be due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68ff4d08cf9b45f680366815d6bf55e8
https://pubmed.ncbi.nlm.nih.gov/10319997

Zobrazit plný text záznamu

Transforming growth factor-beta2 regulates C3 secretion in monocytes through a protein kinase C-dependent pathway

Autor: S M, Drouin, S C, Kiley, J A, Carlino, S R, Barnum

Publikováno v: Molecular immunology. 35(1)

Previously, we reported that TGF-beta2 regulates the C3 gene expression in a dose- and time-dependent manner in monocytes. To extend these studies, we examined the role of PKC in the TGF-beta2-mediated induction of C3 expression by the human monocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75bab037369fc0765c038d81b6c682c1
https://pubmed.ncbi.nlm.nih.gov/9683259

Zobrazit plný text záznamu

Defective microtubule reorganization in phorbol ester-resistant U937 variants: reconstitution of the normal cell phenotype with nocodazole treatment

Autor: S C, Kiley, P J, Parker

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 8(2)

Phorbol ester-induced beta 2-integrin transport to the cell surface is defective in cloned 12-O-tetradecanoylphorbol-13-acetate (TPA)-resistant U937 cell variants. Failure of the integrin-containing vesicles to reach the plasma membrane effectively b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6add2a7b787e9442b6805881e624687
https://pubmed.ncbi.nlm.nih.gov/9040945

Zobrazit plný text záznamu

Cloning and characterization of phorbol ester differentiation-resistant U937 cell variants

Autor: S C, Kiley, P D, Adams, P J, Parker

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 8(2)

Differentiation-resistant U937 cells were derived from parental U937 human promonocytic leukemia cells by selecting for a nonadherent phenotype in cell cultures continuously exposed to 12-O-tetradecanoylphorbol-13-acetate (TPA). Subsequent analysis i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c9cbaf0be1b5c9c9ae242fd6b64ce3f
https://pubmed.ncbi.nlm.nih.gov/9040944

Zobrazit plný text záznamu

Identification of a major protein kinase C-binding protein and substrate in rat embryo fibroblasts. Decreased expression in transformed cells

Autor: C, Chapline, B, Mousseau, K, Ramsay, S, Duddy, Y, Li, S C, Kiley, S, Jaken

Publikováno v: The Journal of biological chemistry. 271(11)

We have used an interaction cloning strategy to isolate cDNAs for sequences that interact with protein kinase C (Chapline, C., Ramsay, K., Klauck, T., and Jaken, S. (1993) J. Biol. Chem. 268,6858-6861). In this paper, we report a novel sequence, clon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a107668a401f02408671cd8fb8271b06
https://pubmed.ncbi.nlm.nih.gov/8626441

Zobrazit plný text záznamu

12-Deoxyphorbol-13-O-phenylacetate-20-acetate is not protein kinase C-beta isozyme-selective in vivo

Autor: Fred J. Evans, W. J. Ryves, Philip C. Gordge, D K Ways, S C Kiley, Peter J. Parker, Andrée R. Olivier

Publikováno v: Carcinogenesis. 15(2)

The phorbol ester, 12-deoxyphorbol-13-O-phenylacetate-20-acetate (DOPPA) has been shown to activate specifically the protein kinase C (PKC)-beta 1 isozyme in vitro (1). We have investigated the potential of DOPPA as a PKC-beta 1/2 isozyme-specific ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708eeb848643b67811bb9a88c89059e1
https://pubmed.ncbi.nlm.nih.gov/8313525

Zobrazit plný text záznamu

Regulation of Protein Kinase C

Autor: Nigel T. Goode, A. R. Olivier, Lodewijk V. Dekker, A. Carozzi, S C Kiley, R. S. Ginger, Peter J. Parker

Publikováno v: Molecular Oncology and Clinical Applications ISBN: 9783034856652

Distinct mechanisms operate to regulate the protein kinase C (PKC) gene family through the production of diacylglycerol (DAG). For the phospholipases C that act upon inositol lipids, agonist induced activation via disparate receptor types involves di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80e170740ae96b3644129953aedcb20b
https://doi.org/10.1007/978-3-0348-5663-8_14

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání