Výsledky vyhledávání - "S. C. Johnston"

Abstract 159: Recurrent Ischemic Stroke And Cigarette Smoking: A Secondary Analysis Of The POINT Trial

Autor: Adam Lang, Brian Mac Grory, Adam H de Havenon, Nils Henninger, Karen L Furie, J D Easton, Anthony S Kim, S C Johnston, Shadi Yaghi

Publikováno v: Stroke. 53

Background: Recent data suggest that in patients with acute myocardial infarction (MI), the effect of clopidogrel on risk reduction of cardiovascular outcomes is more pronounced in smokers. The aim of this study was to determine the effect of smoking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d5d17c5f2311bc8e56c5606b450e701
https://doi.org/10.1161/str.53.suppl_1.159

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Can machine learning augment clinician adjudication of events in cardiovascular trials? A case study of major adverse cardiovascular events (MACE) across CVRM trials

Autor: Tomas Andersson, Halsey Lea, S C Johnston, A Meeson, Jim Weatherall, Anders Persson, Glynn Dennis, E Hutchinson, S Khader, Sreenath Nampally, Faisal Khan, M Wallander

Publikováno v: European Heart Journal. 42

Background and introduction Accurate identification of clinical outcome events is critical to obtaining reliable results in cardiovascular outcomes trials (CVOTs). Current processes for event adjudication are expensive and hampered by delays. As part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5005953efee7e4bfb6e12d020ad3c541
https://doi.org/10.1093/eurheartj/ehab724.3061

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Influence of smoking on CYP 2C19 genetic variants and clopidogrel efficacy in patients with minor stroke or transient ischaemic attack

Autor: T, Wang, Y, Pan, J, Lin, R, Anand, D, Wang, S C, Johnston, X, Meng, H, Li, X, Zhao, L, Liu, Y, Wang

Publikováno v: European Journal of Neurology. 26:1175-1182

BACKGROUND AND PURPOSE Studies suggest that smoking affects clopidogrel efficacy. However, whether it influences the association between CYP2C19 genetic variants and clopidogrel efficacy is not clear. METHODS In total, 2961 patients from the CHANCE t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817db391275470df0f6bd5cd7d85f5a3
https://doi.org/10.1111/ene.13962

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Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack

Autor: A, Wang, X, Zhang, S, Li, X, Zhao, L, Liu, S C, Johnston, X, Meng, J, Lin, Y, Zuo, H, Li, Y, Wang

Publikováno v: European Journal of Neurology. 26:1082-1090

BACKGROUND AND PURPOSE Oxidative stress plays an important role in acute ischaemic stroke. However, the association of oxidative lipoprotein markers, including oxidized low-density lipoprotein (oxLDL), oxLDL:high-density lipoprotein (HDL) and oxLDL:l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dd62a7395cc25f5f655cfa3d11557c
https://doi.org/10.1111/ene.13943

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Higher early recurrence risk and potential benefit of dual antiplatelet therapy for minor stroke with watershed infarction: subgroup analysis of CHANCE

Autor: Xia Meng, Chance Investigators, Xinying Zou, K Atchaneeyasakul, Jing Jing, Xingju Liu, Anxin Wang, Xingquan Zhao, Yuehua Pu, S. C. Johnston, David S Liebeskind, Liping Liu, Yilong Wang, Yuesong Pan

Publikováno v: European journal of neurologyReferences. 27(5)

BACKGROUND AND PURPOSE The aim was to explore the risk of early stroke recurrence within 3 months after watershed infarction and to investigate whether early dual antiplatelet therapy is more effective in decreasing such risk. METHODS Patients enroll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139b787cc7a947da1ea11d3b6c2f1a88
https://pubmed.ncbi.nlm.nih.gov/31997490

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Abstract 89: Effects of the Endpoint Adjudication Process on the Results of the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

Autor: Anne S. Lindblad, Eric E. Adelman, Holly Tillman, Mary Farrant, Point Investigators, Jordan L Elm, Brett Cucchiara, William G. Barsan, J D Easton, S. C Johnston, Yuko Y Palesch, Anthony S. Kim

Publikováno v: Stroke. 50

Introduction: Misclassification of outcome events can potentially lead to biased treatment effect estimates. Efforts to avoid endpoint misclassification in large-scale multicenter randomized clinical trials such as POINT have included an independent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::738e5a2f539536f75346dda8ae2c23fd
https://doi.org/10.1161/str.50.suppl_1.89

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Abstract TP253: Clopidogrel Pharmacogenetics in the POINT Trial

Autor: Karla G. Zurita, Owen A. Ross, J D Easton, Yuko Y Palesch, Point Investigators, James F. Meschia, Luca P. Farrugia, Mary Farrant, Ronald L. Walton, William G. Barsan, Anthony S. Kim, Anne S. Lindblad, S. C Johnston, Jordan Elm

Publikováno v: Stroke. 50

Introduction: Across 269 international sites, the POINT trial randomly assigned 4881 patients with minor ischemic stroke or high-risk transient ischemic attack to receive either clopidogrel at a loading dose of 600 mg on day 1 followed by 75 mg per d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ba4d6db47515f21309164dfd31453ef
https://doi.org/10.1161/str.50.suppl_1.tp253

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Geographic Differences in Endovascular Treatment and Retreatment of Cerebral Aneurysms

Autor: Y.P. Gobin, Demetrius K. Lopes, Yuichi Murayama, Kirsten Carroll, S. C. Johnston, Aquilla S Turk, Joey English, J. Mocco, Cameron G. McDougall, Steven W. Hetts, Charles J. Prestigiacomo

Publikováno v: AJNR. American journal of neuroradiology, vol 37, iss 11
AJNR Am J Neuroradiol

BACKGROUND AND PURPOSE: Comparing outcomes between endovascular aneurysm coiling trials can be difficult because of heterogeneity in patients and end points. We sought to understand the impact of geography on aneurysm retreatment in patients enrolled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f3a425d01c5eda9aa76a5d9fbaf5d6
https://doi.org/10.3174/ajnr.a4857

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Abstract TMP16: Efficacy and Safety of Ticagrelor in Relation to Time to Loading Dose in the SOCRATES Trial

Autor: Yongjun Wang, S. C Johnston, J D Easton, Joachim Röther, Carlos A. Molina, Per Ladenvall, Gregory W. Albers, Kazuo Minematsu, Jenny Jonasson, Scott R. Evans, Peter Held, Ks Lawrence Wong, Hans Denison, Pierre Amarenco

Publikováno v: Stroke. 48

Background: The risk of recurrent ischemia is high in the acute period after transient ischemic attack (TIA) and minor stroke. Therefore, event rates and treatment effects may vary in relation to time to loading dose (TLD) of antiplatelet treatment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ed9cbc34f1cced59aea788efd3f2533
https://doi.org/10.1161/str.48.suppl_1.tmp16

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Abstract TMP20: Efficacy and Safety of Ticagrelor in Relation to Prior Aspirin Usage in the SOCRATES Trial

Autor: Yongjun Wang, Gregory W. Albers, Scott R. Evans, Scott E. Kasner, Carlos A. Molina, Per Ladenvall, Ks Lawrence Wong, S. C Johnston, Hans Denison, Pierre Amarenco, Peter Held, J D Easton, Kazuo Minematsu, Jenny Jonasson

Publikováno v: Stroke. 48

Background: In the SOCRATES study (NCT01994720), addition of ticagrelor to patients on aspirin treatment before randomization may confer the effect of dual antiplatelet therapy as the antiplatelet effect of aspirin persists for more than a week. We a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3888b900bc4154e8f7318219b2a1bc7
https://doi.org/10.1161/str.48.suppl_1.tmp20

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